CEBPD

CEBPD
識別號
别名	CEBPD；, C/EBP-delta, CELF, CRP3, NF-IL6-beta, CCAAT/enhancer binding protein delta, CCAAT enhancer binding protein delta
外部ID	OMIM：116898 MGI：103573 HomoloGene：3808 GeneCards：CEBPD
基因位置（人类）
染色体	8號染色體[1]
终止	47,738,164 bp[1]
基因位置（小鼠）
染色体	小鼠16号染色体[2]
终止	15,708,895 bp[2]
基因本體
分子功能	• DNA结合转录因子活性; • RNA polymerase II cis-regulatory region sequence-specific DNA binding; • DNA结合; • sequence-specific DNA binding; • DNA-binding transcription activator activity, RNA polymerase II-specific; • 血浆蛋白结合; • DNA-binding transcription factor activity, RNA polymerase II-specific; • protein homodimerization activity; • protein heterodimerization activity;
細胞組分	• 细胞核; • 核质;
生物學過程	• regulation of transcription, DNA-templated; • transcription, DNA-templated; • positive regulation of transcription by RNA polymerase II; • transcription by RNA polymerase II; • cytokine-mediated signaling pathway; • hematopoietic progenitor cell differentiation; • regulation of transcription by RNA polymerase II; • fat cell differentiation; • positive regulation of osteoblast differentiation; • negative regulation of transcription, DNA-templated; • 内耳的发生;
	Sources:Amigo / QuickGO
直系同源
	1052
	12609
	ENSG00000221869
	ENSMUSG00000071637
	P49716
	Q00322
	NM_005195
	NM_007679
	NP_005186
	NP_031705
	維基數據

CCAAT/增强子结合蛋白δ，简称C/EBP-δ或CEBPD，是一种在人类中由CEBPD基因编码的蛋白质。[5][6]

功能

由这种无内含子基因编码的蛋白质是一种bZIP转录因子，它可以作为同源二聚体与某些DNA调节区结合。它还可以与相关蛋白C/EBP-α形成异二聚体。编码的蛋白质在调节参与免疫和炎症反应的基因中很重要，并且可能参与调节与巨噬细胞活化和/或分化相关的基因。[7]

CEBPD参与细胞凋亡和细胞增殖的调节。它可能充当肿瘤抑制因子。[8]

一项针对小鼠的研究表明，CEBPD在慢性阻塞性肾病进展过程中可防止肾小管损伤和肾小管间质纤维化的发展。[9]

CEBPD基因的功能可以通过基于独立验证的siRNA敲低来有效检查。[10]

相互作用

CEBPD已被证明能与SMAD3相互作用。[11]

参见

CCAAT增强子结合蛋白

参考文献

GRCh38: Ensembl release 89: ENSG00000221869 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000071637 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Cao Z, Umek RM, McKnight SL. . Genes & Development. Sep 1991, 5 (9): 1538–52. PMID 1840554. doi:10.1101/gad.5.9.1538 .
Williams SC, Cantwell CA, Johnson PF. . Genes & Development. Sep 1991, 5 (9): 1553–67. PMID 1884998. doi:10.1101/gad.5.9.1553 .
.
Gery S, Tanosaki S, Hofmann WK, Koppel A, Koeffler HP. . Oncogene. Feb 2005, 24 (9): 1589–97. PMID 15674331. doi:10.1038/sj.onc.1208393 .
Duitman J, Borensztajn KS, Pulskens WP, Leemans JC, Florquin S, Spek CA. . Laboratory Investigation; A Journal of Technical Methods and Pathology. Jan 2014, 94 (1): 89–97. PMID 24247561. doi:10.1038/labinvest.2013.127 .
Munkácsy, Gyöngyi; Sztupinszki, Zsófia; Herman, Péter; Bán, Bence; Pénzváltó, Zsófia; Szarvas, Nóra; Győrffy, Balázs. . Molecular Therapy: Nucleic Acids. 2016, 5 (9): e366. ISSN 2162-2531. PMC 5056990 . PMID 27673562. doi:10.1038/mtna.2016.66 （英语）.
Choy L, Derynck R. . The Journal of Biological Chemistry. Mar 2003, 278 (11): 9609–19. PMID 12524424. doi:10.1074/jbc.M212259200 .

阅读

Sladek FM, Darnell JE. . Current Opinion in Genetics & Development. Apr 1992, 2 (2): 256–9. PMID 1638120. doi:10.1016/S0959-437X(05)80282-5.
Kinoshita S, Akira S, Kishimoto T. . Proceedings of the National Academy of Sciences of the United States of America. Feb 1992, 89 (4): 1473–6. Bibcode:1992PNAS...89.1473K. PMC 48473 . PMID 1741402. doi:10.1073/pnas.89.4.1473 .
Nagulapalli S, Pongubala JM, Atchison ML. . Journal of Immunology. Nov 1995, 155 (9): 4330–8. PMID 7594592.
Wood S, Schertzer M, Yaremko ML. . Cytogenetics and Cell Genetics. 1995, 70 (3–4): 188–91. PMID 7789168. doi:10.1159/000134030.
Cleutjens CB, van Eekelen CC, van Dekken H, Smit EM, Hagemeijer A, Wagner MJ, Wells DE, Trapman J. . Genomics. May 1993, 16 (2): 520–3. PMID 8314590. doi:10.1006/geno.1993.1220.
Chen PL, Riley DJ, Chen Y, Lee WH. . Genes & Development. Nov 1996, 10 (21): 2794–804. PMID 8946919. doi:10.1101/gad.10.21.2794 .
Xia C, Cheshire JK, Patel H, Woo P. . The International Journal of Biochemistry & Cell Biology. Dec 1997, 29 (12): 1525–39. PMID 9570146. doi:10.1016/S1357-2725(97)00083-6.
Zhu Y, Saunders MA, Yeh H, Deng WG, Wu KK. . The Journal of Biological Chemistry. Mar 2002, 277 (9): 6923–8. PMID 11741938. doi:10.1074/jbc.M108075200 .
Angeloni D, Lee JD, Johnson BE, Teh BT, Dean M, Lerman MI, Sterneck E. . Molecular and Cellular Probes. Dec 2001, 15 (6): 395–7. PMID 11851384. S2CID 8215328. doi:10.1006/mcpr.2001.0377. hdl:11382/3170 .
Gao H, Parkin S, Johnson PF, Schwartz RC. . The Journal of Biological Chemistry. Oct 2002, 277 (41): 38827–37. PMID 12177065. doi:10.1074/jbc.M206224200 .
Dearth LR, DeWille J. . The Journal of Biological Chemistry. Mar 2003, 278 (13): 11246–55. PMID 12554732. doi:10.1074/jbc.M207930200 .
Milde-Langosch K, Löning T, Bamberger AM. . Breast Cancer Research and Treatment. May 2003, 79 (2): 175–85. PMID 12825852. S2CID 45020949. doi:10.1023/A:1023929504884.
Kovács KA, Steinmann M, Magistretti PJ, Halfon O, Cardinaux JR. . The Journal of Biological Chemistry. Sep 2003, 278 (38): 36959–65. PMID 12857754. doi:10.1074/jbc.M303147200 .
Chen YW, Hubal MJ, Hoffman EP, Thompson PD, Clarkson PM. . Journal of Applied Physiology. Dec 2003, 95 (6): 2485–94. PMID 12937035. S2CID 9817319. doi:10.1152/japplphysiol.01161.2002.
Li R, Strohmeyer R, Liang Z, Lue LF, Rogers J. . Neurobiology of Aging. Sep 2004, 25 (8): 991–9. PMID 15212823. S2CID 54232508. doi:10.1016/j.neurobiolaging.2003.10.016.
Sivko GS, Sanford DC, Dearth LD, Tang D, DeWille JW. . Journal of Cellular Biochemistry. Nov 2004, 93 (4): 844–56. PMID 15389878. S2CID 31572695. doi:10.1002/jcb.20224.

外部链接

Human CEBPD genome location and CEBPD gene details page in the UCSC Genome Browser.
醫學主題詞表（MeSH）：CEBPD+protein,+human

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000221869 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000071637 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1840554-5] Cao Z, Umek RM, McKnight SL. . Genes & Development. Sep 1991, 5 (9): 1538–52. PMID 1840554. doi:10.1101/gad.5.9.1538 .

[pmid1884998-6] Williams SC, Cantwell CA, Johnson PF. . Genes & Development. Sep 1991, 5 (9): 1553–67. PMID 1884998. doi:10.1101/gad.5.9.1553 .

[entrez-7] .

[pmid_=_15674331-8] Gery S, Tanosaki S, Hofmann WK, Koppel A, Koeffler HP. . Oncogene. Feb 2005, 24 (9): 1589–97. PMID 15674331. doi:10.1038/sj.onc.1208393 .

[pmid_=_24247561-9] Duitman J, Borensztajn KS, Pulskens WP, Leemans JC, Florquin S, Spek CA. . Laboratory Investigation; A Journal of Technical Methods and Pathology. Jan 2014, 94 (1): 89–97. PMID 24247561. doi:10.1038/labinvest.2013.127 .

[10] Munkácsy, Gyöngyi; Sztupinszki, Zsófia; Herman, Péter; Bán, Bence; Pénzváltó, Zsófia; Szarvas, Nóra; Győrffy, Balázs. . Molecular Therapy: Nucleic Acids. 2016, 5 (9): e366. ISSN 2162-2531. PMC 5056990 . PMID 27673562. doi:10.1038/mtna.2016.66 （英语）.

[pmid12524424-11] Choy L, Derynck R. . The Journal of Biological Chemistry. Mar 2003, 278 (11): 9609–19. PMID 12524424. doi:10.1074/jbc.M212259200 .