α-烯醇化酶

Α-烯醇化酶
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	2PSN、3B97
識別號
别名	ENO1；, ENO1L1, MPB1, NNE, PPH, HEL-S-17, enolase 1
外部ID	OMIM：172430 MGI：3648653 HomoloGene：134343 GeneCards：ENO1
基因位置（人类）
染色体	1號染色體[1]
终止	8,879,190 bp[1]
基因位置（小鼠）
染色体	小鼠18号染色体[2]
终止	48,181,479 bp[2]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• DNA结合; • 金屬離子結合; • 血浆蛋白结合; • lyase activity; • GTPase binding; • magnesium ion binding; • RNA binding; • cadherin binding; • DNA结合转录阻遏物活性，RNA聚合酶II特异性; • phosphopyruvate hydratase activity; • protein homodimerization activity; • RNA polymerase II transcription regulatory region sequence-specific DNA binding;
細胞組分	• 細胞質; • M band; • 膜; • 外排體; • 细胞核; • 細胞外空間; • phosphopyruvate hydratase complex; • 细胞质基质; • 细胞膜; • cell surface; • cell cortex region;
生物學過程	• 糖异生; • regulation of transcription, DNA-templated; • 糖酵解; • response to virus; • transcription, DNA-templated; • negative regulation of cell growth; • negative regulation of transcription, DNA-templated; • negative regulation of transcription by RNA polymerase II; • positive regulation of plasminogen activation; • positive regulation of muscle contraction; • canonical glycolysis; • negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway; • positive regulation of ATP biosynthetic process;
	Sources:Amigo / QuickGO
直系同源
	2023
	433182
	ENSG00000074800
	ENSMUSG00000059040
	P06733
	P17182
	NM_001201483; NM_001428; NM_001353346
	NM_001025388
	NP_001188412; NP_001419; NP_001340275
	NP_001366056; NP_001366057; NP_075608; NP_001020559
	維基數據

α-烯醇化酶（英語：），也称为烯醇化酶1（enolase 1，ENO1）是人类基因组中编码的三种烯醇化酶（也称做“磷酸烯醇式丙酮酸水合酶”， phosphopyruvate hydratase）之一，以相同亚基形成的蛋白二聚体执行功能，存在選擇性剪接[5]。

参考文献

GRCh38: Ensembl release 89: ENSG00000074800 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000059040 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. NCBI Entrez Gene database. [2023-04-18]. （原始内容存档于2023-05-03）.

外部链接

Alpha-Enolase Linked to Severe Asthma - medscape news report, 25 aug 2006.
Human ENO1 genome location and ENO1 gene details page in the UCSC Genome Browser.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000074800 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059040 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] . NCBI Entrez Gene database. [2023-04-18]. （原始内容存档于2023-05-03）.