EPAS1

EPAS1
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1P97、2A24、3F1N、3F1O、3F1P、3H7W、3H82、4GHI、4GS9、4PKY、4XT2
識別號
别名	EPAS1；, ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73, endothelial PAS domain protein 1, Hypoxia-inducible factor-2alpha
外部ID	OMIM：603349 MGI：109169 HomoloGene：1095 GeneCards：EPAS1
相關疾病
	腎細胞腫瘤[1]
基因位置（人类）
染色体	2號染色體[2]
终止	46,386,697 bp[2]
基因位置（小鼠）
染色体	小鼠17号染色体[3]
终止	87,140,838 bp[3]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• DNA结合; • sequence-specific DNA binding; • protein dimerization activity; • DNA结合转录因子活性; • DNA-binding transcription activator activity, RNA polymerase II-specific; • 转录因子结合; • 血浆蛋白结合; • histone acetyltransferase binding; • protein heterodimerization activity; • DNA-binding transcription factor activity, RNA polymerase II-specific;
細胞組分	• 細胞質; • 细胞质基质; • nuclear speck; • 轉錄調節複合物; • 核质; • 细胞核;
生物學過程	• surfactant homeostasis; • 细胞分化; • response to hypoxia; • regulation of transcription, DNA-templated; • regulation of transcription from RNA polymerase II promoter in response to oxidative stress; • lung development; • norepinephrine metabolic process; • iron ion homeostasis; • mitochondrion organization; • embryonic placenta development; • cell maturation; • response to oxidative stress; • transcription, DNA-templated; • regulation of heart rate; • multicellular organism development; • blood vessel remodeling; • myoblast fate commitment; • 血管新生; • regulation of transcription from RNA polymerase II promoter in response to hypoxia; • erythrocyte differentiation; • 訊息傳遞; • 視覺; • positive regulation of transcription by RNA polymerase II; • cellular response to hypoxia; • transcription by RNA polymerase II; • 翻译后修饰; • 造血作用; • regulation of transcription by RNA polymerase II; • positive regulation of cold-induced thermogenesis; • protein ubiquitination;
	Sources:Amigo / QuickGO
直系同源
	2034
	13819
	ENSG00000116016
	ENSMUSG00000024140
	Q99814
	P97481
	NM_001430
	NM_010137
	NP_001421
	NP_034267
	維基數據

内皮PAS结构域包含蛋白-1（英語：，缩写EPAS1，也被称为缺氧诱导因子-2α亚基，英語：，缩写HIF-2α）是一种由人类基因 EPAS1 所编码的蛋白质[6][7][8][9]。

功能

EPAS1所表达的蛋白是一个转录因子的组成部分，该转录因子介导一些受氧气调控基因的表达，特别是低氧（缺氧）环境下。该蛋白包含一个碱性螺旋-环-螺旋蛋白二聚化结构域，此结构域也常见于其它氧应激相关信号通路蛋白。EPAS1涉及胚胎心脏的发育，并在脐带的血管壁内皮细胞中表达。EPAS1维持儿茶酚胺类物质在胚胎早期发育中的稳定，以防止心臟衰竭[9]。儿茶酚胺类物质包括肾上腺素和去甲肾上腺素，其稳定对胎儿与成人的心脏的健康有着重要作用[10]。

交互作用

EPAS1能与芳香烃受体核转位子[7]和ARNTL[11]发生交互作用。

參考

人類的高海拔適應
丹尼索瓦人

註釋

.
GRCh38: Ensembl release 89: ENSG00000116016 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024140 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Tian H, McKnight SL, Russell DW. . Genes Dev. Feb 1997, 11 (1): 72–82. PMID 9000051. doi:10.1101/gad.11.1.72.
Hogenesch JB, Chan WK, Jackiw VH, Brown RC, Gu YZ, Pray-Grant M, Perdew GH, Bradfield CA. . J Biol Chem. May 1997, 272 (13): 8581–93. PMID 9079689. doi:10.1074/jbc.272.13.8581.
Percy MJ, Beer PA, Campbell G, Dekker AW, Green AR, Oscier D, Rainey MG, van Wijk R, Wood M, Lappin TR, McMullin MF, Lee FS. . Blood. May 2008, 111 (11): 5400–2. PMC 2396730 . PMID 18378852. doi:10.1182/blood-2008-02-137703.
. （原始内容存档于2019-10-16）.
Tian H, Hammer RE, Matsumoto AM, Russell DW, McKnight SL. . Genes Dev. November 1998, 12 (21): 3320–4. PMC 317225 . PMID 9808618. doi:10.1101/gad.12.21.3320.
Hogenesch JB, Gu YZ, Jain S, Bradfield CA. . Proc. Natl. Acad. Sci. U.S.A. May 1998, 95 (10): 5474–9. PMC 20401 . PMID 9576906. doi:10.1073/pnas.95.10.5474.

参考文献

EPAS1引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。

延伸阅读

Brahimi-Horn MC, Pouysségur J. . Int. Rev. Cytol. 2005, 242: 157–213. PMID 15598469. doi:10.1016/S0074-7696(04)42004-X.
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Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA. . Anal. Biochem. 1996, 236 (1): 107–13. PMID 8619474. doi:10.1006/abio.1996.0138.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA. . Genome Res. 1997, 7 (4): 353–8. PMC 139146 . PMID 9110174. doi:10.1101/gr.7.4.353.
Ema M, Taya S, Yokotani N, Sogawa K, Matsuda Y, Fujii-Kuriyama Y. . Proc. Natl. Acad. Sci. U.S.A. 1997, 94 (9): 4273–8. PMC 20712 . PMID 9113979. doi:10.1073/pnas.94.9.4273.
Hogenesch JB, Gu YZ, Jain S, Bradfield CA. . Proc. Natl. Acad. Sci. U.S.A. 1998, 95 (10): 5474–9. PMC 20401 . PMID 9576906. doi:10.1073/pnas.95.10.5474.
Takahata S, Sogawa K, Kobayashi A, Ema M, Mimura J, Ozaki N, Fujii-Kuriyama Y. . Biochem. Biophys. Res. Commun. 1998, 248 (3): 789–94. PMID 9704006. doi:10.1006/bbrc.1998.9012.
Ema M, Hirota K, Mimura J, Abe H, Yodoi J, Sogawa K, Poellinger L, Fujii-Kuriyama Y. . EMBO J. 1999, 18 (7): 1905–14. PMC 1171276 . PMID 10202154. doi:10.1093/emboj/18.7.1905.
Cockman ME, Masson N, Mole DR, Jaakkola P, Chang GW, Clifford SC, Maher ER, Pugh CW, Ratcliffe PJ, Maxwell PH. . J. Biol. Chem. 2000, 275 (33): 25733–41. PMID 10823831. doi:10.1074/jbc.M002740200.
Maemura K, de la Monte SM, Chin MT, Layne MD, Hsieh CM, Yet SF, Perrella MA, Lee ME. . J. Biol. Chem. 2001, 275 (47): 36847–51. PMID 11018023. doi:10.1074/jbc.C000629200.
Luo JC, Shibuya M. . Oncogene. 2001, 20 (12): 1435–44. PMID 11313887. doi:10.1038/sj.onc.1204228.
Woods SL, Whitelaw ML. . J. Biol. Chem. 2002, 277 (12): 10236–43. PMID 11782478. doi:10.1074/jbc.M110752200.
Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML. . Science. 2002, 295 (5556): 858–61. PMID 11823643. doi:10.1126/science.1068592.
Mole DR, Pugh CW, Ratcliffe PJ, Maxwell PH. . Adv. Enzyme Regul. 2002, 42: 333–47. PMID 12123724. doi:10.1016/S0065-2571(01)00037-1.
Sivridis E, Giatromanolaki A, Gatter KC, Harris AL, Koukourakis MI. . Cancer. 2002, 95 (5): 1055–63. PMID 12209691. doi:10.1002/cncr.10774.
Elvert G, Kappel A, Heidenreich R, Englmeier U, Lanz S, Acker T, Rauter M, Plate K, Sieweke M, Breier G, Flamme I. . J. Biol. Chem. 2003, 278 (9): 7520–30. PMID 12464608. doi:10.1074/jbc.M211298200.
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外部链接

醫學主題詞表（MeSH）：EPAS1+protein,+human

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[1] .

[refGRCh38Ensembl-2] GRCh38: Ensembl release 89: ENSG00000116016 - Ensembl, May 2017

[refGRCm38Ensembl-3] GRCm38: Ensembl release 89: ENSMUSG00000024140 - Ensembl, May 2017

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9000051-6] Tian H, McKnight SL, Russell DW. . Genes Dev. Feb 1997, 11 (1): 72–82. PMID 9000051. doi:10.1101/gad.11.1.72.

[pmid9079689-7] Hogenesch JB, Chan WK, Jackiw VH, Brown RC, Gu YZ, Pray-Grant M, Perdew GH, Bradfield CA. . J Biol Chem. May 1997, 272 (13): 8581–93. PMID 9079689. doi:10.1074/jbc.272.13.8581.

[pmid18378852-8] Percy MJ, Beer PA, Campbell G, Dekker AW, Green AR, Oscier D, Rainey MG, van Wijk R, Wood M, Lappin TR, McMullin MF, Lee FS. . Blood. May 2008, 111 (11): 5400–2. PMC 2396730 . PMID 18378852. doi:10.1182/blood-2008-02-137703.

[entrez-9] . （原始内容存档于2019-10-16）.

[pmid9808618-10] Tian H, Hammer RE, Matsumoto AM, Russell DW, McKnight SL. . Genes Dev. November 1998, 12 (21): 3320–4. PMC 317225 . PMID 9808618. doi:10.1101/gad.12.21.3320.

[pmid9576906-11] Hogenesch JB, Gu YZ, Jain S, Bradfield CA. . Proc. Natl. Acad. Sci. U.S.A. May 1998, 95 (10): 5474–9. PMC 20401 . PMID 9576906. doi:10.1073/pnas.95.10.5474.