HADHB

HADHB
識別號
别名	HADHB；, ECHB, MSTP029, MTPB, TP-BETA, hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit, hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
外部ID	OMIM：143450 MGI：2136381 HomoloGene：153 GeneCards：HADHB
基因位置（人类）
染色体	2號染色體[1]
终止	26,290,465 bp[1]
基因位置（小鼠）
染色体	小鼠5号染色体[2]
终止	30,389,591 bp[2]
基因本體
分子功能	• 轉移酶活性; • acyltransferase activity, transferring groups other than amino-acyl groups; • enoyl-CoA hydratase activity; • long-chain-3-hydroxyacyl-CoA dehydrogenase activity; • 血浆蛋白结合; • 催化活性; • acyltransferase activity; • 3-hydroxyacyl-CoA dehydrogenase activity; • RNA binding; • acetyl-CoA C-acyltransferase activity; • long-chain-enoyl-CoA hydratase activity;
細胞組分	• 膜; • mitochondrial outer membrane; • 内质网; • mitochondrial inner membrane; • mitochondrial envelope; • 线粒体拟核; • 外排體; • 線粒體;
生物學過程	• 脂質代謝; • 脂肪酸代謝; • 代謝; • cardiolipin acyl-chain remodeling; • fatty acid beta-oxidation;
	Sources:Amigo / QuickGO
直系同源
	3032
	231086
	ENSG00000138029
	ENSMUSG00000059447
	P55084
	Q99JY0
	NM_000183; NM_001281512; NM_001281513
	NM_145558; NM_001289798; NM_001289799
	NP_000174; NP_001268441; NP_001268442
	NP_001276727; NP_001276728; NP_663533
	維基數據

线粒体三功能酶β亚基（英語：，TP-beta）也被称为3-ketoacyl-CoA thiolase、acetyl-CoA acyltransferase或beta-ketothiolase 是一种由人类基因 HADHB 所编码的酶[5]。

HADHB是线粒体三功能蛋白的一个亚基，并具有硫解酶活性。

结构

HADHB基因位于2号染色体的2p23段[5]，包括17个外显子，蛋白分子量为51.2 kDa，包括474个氨基酸残基[6][7]。

功能

参考文献

GRCh38: Ensembl release 89: ENSG00000138029 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000059447 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. （原始内容存档于2009-10-19）.
]Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P. . Circulation Research. October 2013, 113 (9): 1043–53. PMC 4076475 . PMID 23965338. doi:10.1161/CIRCRESAHA.113.301151.
. Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). [2019-07-07]. （原始内容存档于2016-03-04）.

延伸阅读

Wang R, Yang Z, Zhu JM; et al. . Zhonghua Fu Chan Ke Za Zhi. 2006, 41 (10): 672–5. PMID 17199921.
Aboulaich N, Vainonen JP, StrÃ¥lfors P, Vener AV. . Biochem. J. 2004, 383 (Pt 2): 237–48. PMC 1134064 . PMID 15242332. doi:10.1042/BJ20040647.
Adams DJ, Beveridge DJ, van der Weyden L; et al. . J. Biol. Chem. 2003, 278 (45): 44894–903. PMID 12933794. doi:10.1074/jbc.M307782200.
Spiekerkoetter U, Khuchua Z, Yue Z; et al. . Pediatr. Res. 2004, 55 (2): 190–6. PMID 14630990. doi:10.1203/01.PDR.0000103931.80055.06.
Kimura K, Wakamatsu A, Suzuki Y; et al. . Genome Res. 2006, 16 (1): 55–65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406.
Bogenhagen DF, Rousseau D, Burke S. . J. Biol. Chem. 2008, 283 (6): 3665–75. PMID 18063578. doi:10.1074/jbc.M708444200.
Middleton B. . Biochem. Soc. Trans. 1994, 22 (2): 427–31. PMID 7958339.
Zhao Y, Meng XM, Wei YJ; et al. . J. Mol. Med. 2003, 81 (5): 297–304. PMID 12721663. doi:10.1007/s00109-003-0427-x.
Behrends C, Sowa ME, Gygi SP, Harper JW. . Nature. 2010, 466 (7302): 68–76. PMC 2901998 . PMID 20562859. doi:10.1038/nature09204.
Purevsuren J, Fukao T, Hasegawa Y; et al. . Mol. Genet. Metab. 2009, 98 (4): 372–7. PMID 19699128. doi:10.1016/j.ymgme.2009.07.011.
Hillier LW, Graves TA, Fulton RS; et al. . Nature. 2005, 434 (7034): 724–31. PMID 15815621. doi:10.1038/nature03466.
Spiekerkoetter U, Sun B, Khuchua Z; et al. . Hum. Mutat. 2003, 21 (6): 598–607. PMID 12754706. doi:10.1002/humu.10211.
Gerhard DS, Wagner L, Feingold EA; et al. . Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Ota T, Suzuki Y, Nishikawa T; et al. . Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Fould B, Garlatti V, Neumann E; et al. . Biochemistry. 2010, 49 (39): 8608–17. PMID 20825197. doi:10.1021/bi100742w.
Strausberg RL, Feingold EA, Grouse LH; et al. . Proc. Natl. Acad. Sci. U.S.A. 2002, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Ibdah JA, Tein I, Dionisi-Vici C; et al. . J. Clin. Invest. 1998, 102 (6): 1193–9. PMID 9739053. doi:10.1172/JCI2091.
Gevaert K, Goethals M, Martens L; et al. . Nat. Biotechnol. 2003, 21 (5): 566–9. PMID 12665801. doi:10.1038/nbt810.
Hendrickson SL, Lautenberger JA, Chinn LW; et al. . PLoS ONE. 2010, 5 (9): e12862. PMC 2943476 . PMID 20877624. doi:10.1371/journal.pone.0012862.
Frackowiak J, Mazur-Kolecka B, Kaczmarski W, Dickson D. . Brain Res. 2001, 907 (1-2): 44–53. PMID 11430884. doi:10.1016/S0006-8993(01)02497-0.

外部链接

醫學主題詞表（MeSH）：HADHB+protein,+human

HADHB引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138029 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059447 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] . （原始内容存档于2009-10-19）.

[COPaKB-6] ]Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P. . Circulation Research. October 2013, 113 (9): 1043–53. PMC 4076475 . PMID 23965338. doi:10.1161/CIRCRESAHA.113.301151.

[url_COPaKB-7] . Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). [2019-07-07]. （原始内容存档于2016-03-04）.