HIST4H4

HIST4H4
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	4H9O、3WKJ、3AYW、3WA9、5B0Z、5AVB、2CV5、5AV5、3AV2、3WTP、3AV1、3AZK、3X1V、5AV8、1F66、4QUU、3CFS、4YYK、4QUT、3NQJ、3A6N、3W99、5AVC、2RS9、3F9Z、3QZT、3QBY、3W97、4M38、4YM6、3CFV、4HGA、1EQZ、2RJE、3QZV、1HQ3、4H9P、3AZL、3AFA、1TZY、3UVY、5CPK、3JPX、4U9W、4N3W、4YYJ、4YYD、4H9N、4H9R、3AZI、4LD9、3UVX、3AZH、5BNX、4N4F、1U35、4YYG、3O36、2ARO、5AV9、4H9S、3AZF、3W98、4GQB、4H9Q、5BNV、3WAA、3AZG、3AZE、2RNY、1ZKK、2QQS、2LVM、3X1T、3AN2、2KWO、3QZS、3F9W、5FFW、5CPJ、3F9X、3IJ1、4YM5、3AZJ、4YY6、3AZN、2IG0、4YYH、4YYI、5CPI、3W96、3R45、2KWN、3F9Y、5AV6、3AZM、5BO0、3X1S、4QYD、4KGC、3UVW、4YYN、3X1U、3UW9、2F8N、3NQU、5B0Y、4YYM、5C3I、4Z5T、5B24、5FA5、4Z2M、5E5A、5FWE、5B2I、5B40、5B2J、5JA4、5AY8、4ZUX
識別號
别名	H4-16；, H4/p, histone cluster 4, H4, histone cluster 4 H4, HIST4H4, H4 histone 16, H4C5, H4C4, H4C9, H4C12, H4C3, H4C13, H4C11, H4C1, H4C14, H4C15, H4C8, H4C6, H4C2, H4C16
外部ID	OMIM：615069 MGI：2448432 HomoloGene：134468 GeneCards：H4-16
基因位置（人类）
染色体	12號染色體[1]
终止	14,771,131 bp[1]
基因位置（小鼠）
染色体	小鼠13号染色体[2]
终止	22,225,532 bp[2]
基因本體
分子功能	• protein domain specific binding; • 血浆蛋白结合; • protein heterodimerization activity; • DNA结合; • histone binding; • RNA binding;
細胞組分	• 膜; • 染色体; • 核质; • 細胞外區域; • nuclear chromosome; • 核小體; • 外排體; • 细胞核; • 细胞外间质; • 大分子复合体;
生物學過程	• telomere organization; • epigenetic maintenance of chromatin in transcription-competent conformation; • protein heterotetramerization; • negative regulation of megakaryocyte differentiation; • CENP-A containing chromatin assembly; • DNA replication-dependent chromatin assembly; • rDNA heterochromatin assembly; • negative regulation of gene expression, epigenetic; • DNA-templated transcription, initiation; • double-strand break repair via nonhomologous end joining; • beta-catenin-TCF complex assembly; • telomere capping; • nucleosome assembly; • regulation of gene silencing by miRNA; • regulation of megakaryocyte differentiation; • regulation of hematopoietic stem cell differentiation;
	Sources:Amigo / QuickGO
直系同源
	121504
	319158
	ENSG00000197837
	ENSMUSG00000060639
	P62805
	P62806
	NM_175054
	NM_175656
NP_003537; NP_003486; NP_003535; NP_003539; NP_003531;
	NP_003536
NP_291074; NP_783587; NP_783588; NP_835499; NP_835500;
	NP_001182350; NP_835515; NP_783585; NP_783586; NP_835582; NP_835583; NP_783583; NP_694813
	維基數據

HIST4H4爲人體中的一種編碼一類組蛋白H4的基因[5]。HIST4H4沒有內含子，編碼組蛋白H4家族中的一種蛋白質。HIST4H4基因對應的mRNA缺乏Poly(A)尾巴。不過，這類mRNA有一個回文終止元件[6]。

參考

GRCh38: Ensembl release 89: ENSG00000197837 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000060639 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ. . Genomics. Oct 2002, 80 (5): 487–98. PMID 12408966. doi:10.1016/S0888-7543(02)96850-3.
. （原始内容存档于2019-10-17）.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000197837 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000060639 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12408966-5] Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ. . Genomics. Oct 2002, 80 (5): 487–98. PMID 12408966. doi:10.1016/S0888-7543(02)96850-3.

[entrez-6] . （原始内容存档于2019-10-17）.