ID3 (基因)

ID3
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	2LFH
識別號
别名	ID3；, HEIR-1, bHLHb25, inhibitor of DNA binding 3, HLH protein
外部ID	OMIM：600277 MGI：96398 HomoloGene：1633 GeneCards：ID3
基因位置（人类）
染色体	1號染色體[1]
终止	23,559,501 bp[1]
基因位置（小鼠）
染色体	小鼠4号染色体[2]
终止	135,873,066 bp[2]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• protein dimerization activity; • leptomycin B binding; • transcription corepressor activity; • protein domain specific binding; • DNA结合转录因子活性; • 转录因子结合; • 血浆蛋白结合; • DNA-binding transcription factor activity, RNA polymerase II-specific;
細胞組分	• 細胞質; • 细胞核;
生物學過程	• negative regulation of myoblast differentiation; • regulation of transcription, DNA-templated; • epithelial cell differentiation; • rhythmic process; • regulation of DNA replication; • muscle organ development; • notochord development; • negative regulation of transcription by RNA polymerase II; • negative regulation of DNA-binding transcription factor activity; • negative regulation of osteoblast differentiation; • transcription, DNA-templated; • negative regulation of gene expression; • regulation of cell cycle; • odontogenesis; • multicellular organism development; • 心脏发育; • central nervous system development; • response to wounding; • 昼夜节律; • neuron differentiation; • positive regulation of apoptotic process; • metanephros development; • negative regulation of transcription, DNA-templated; • cellular response to leptomycin B; • negative regulation of DNA binding; • negative regulation of neuron differentiation;
	Sources:Amigo / QuickGO
直系同源
	3399
	15903
	ENSG00000283060; ENSG00000117318
	ENSMUSG00000007872
	Q02535
	P41133
	NM_002167
	NM_008321
	NP_002158
	NP_032347
	維基數據

ID3（分化抑制因子3，Inhibitor of Differentiation 3），正式名稱爲「inhibitor of DNA binding 3, HLH protein」（DNA結合抑制因子3，HLH（螺旋-環-螺旋）蛋白）。人ID3蛋白由ID3基因編碼[5][6]。

功能

分化抑制因子（ID）家族螺旋-環-螺旋（HLH）蛋白質缺乏基因的DNA結合結構域。它通過與其他的HLH蛋白形成異二聚體，阻止其與DNA結合，進而抑制其功能[6]。

相互作用

ID3能與TCF3（轉錄因子3）發生相互作用[7][8]。

ID3的抑制劑

BTG2能與ID3基因的啓動子結合，進而抑制其ID3基因的活性。如果敲除海馬的BTG2基因的話，海馬ID3表達就會上調，進而使其神經元無法發生末端分化[9]。

參見

DNA結合抑制蛋白

參考

GRCh38: Ensembl release 89: ENSG00000283060、ENSG00000117318 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000007872 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Ellmeier W, Aguzzi A, Kleiner E, Kurzbauer R, Weith A. . EMBO J. Aug 1992, 11 (7): 2563–71. PMC 556731 . PMID 1628620.
. （原始内容存档于2019-10-17）.
Deed RW, Jasiok M, Norton JD. . J. Biol. Chem. Apr 1998, 273 (14): 8278–86. PMID 9525934. doi:10.1074/jbc.273.14.8278.
Langlands K, Yin X, Anand G, Prochownik EV. . J. Biol. Chem. Aug 1997, 272 (32): 19785–93. PMID 9242638. doi:10.1074/jbc.272.32.19785.
Farioli-Vecchioli S, Saraulli D, Costanzi M, Leonardi L, Cinà I, Micheli L, Nutini M, Longone P, Oh SP, Cestari V, Tirone F. Okazawa H , 编. . PLoS ONE. 2009, 4 (12): e8339. PMC 2791842 . PMID 20020054. doi:10.1371/journal.pone.0008339.

拓展閱讀

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Deed RW, Hirose T, Mitchell EL, Santibanez-Koref MF, Norton JD. . Gene. 1994, 151 (1-2): 309–14. PMID 7828896. doi:10.1016/0378-1119(94)90676-9.
Deed RW, Bianchi SM, Atherton GT, Johnston D, Santibanez-Koref M, Murphy JJ, Norton JD. . Oncogene. 1993, 8 (3): 599–607. PMID 8437843.
Ishiguro A, Spirin K, Shiohara M, Tobler A, Norton JD, Rigolet M, Shimbo T, Koeffler HP. . Leuk. Res. 1995, 19 (12): 989–96. PMID 8632670. doi:10.1016/0145-2126(95)00084-4.
Wibley J, Deed R, Jasiok M, Douglas K, Norton J. . Biochim. Biophys. Acta. 1996, 1294 (2): 138–46. PMID 8645731. doi:10.1016/0167-4838(96)00008-8.
Loveys DA, Streiff MB, Kato GJ. . Nucleic Acids Res. 1996, 24 (14): 2813–20. PMC 145994 . PMID 8759016. doi:10.1093/nar/24.14.2813.
Deed RW, Armitage S, Norton JD. . J. Biol. Chem. 1996, 271 (39): 23603–6. PMID 8798572. doi:10.1074/jbc.271.39.23603.
Deed RW, Jasiok M, Norton JD. . FEBS Lett. 1996, 393 (1): 113–6. PMID 8804437. doi:10.1016/0014-5793(96)00868-X.
Chen B, Lim RW. . J. Biol. Chem. 1997, 272 (4): 2459–63. PMID 8999959. doi:10.1074/jbc.272.4.2459.
Langlands K, Yin X, Anand G, Prochownik EV. . J. Biol. Chem. 1997, 272 (32): 19785–93. PMID 9242638. doi:10.1074/jbc.272.32.19785.
Deed RW, Hara E, Atherton GT, Peters G, Norton JD. . Mol. Cell. Biol. 1997, 17 (12): 6815–21. PMC 232537 . PMID 9372912.
Deed RW, Jasiok M, Norton JD. . J. Biol. Chem. 1998, 273 (14): 8278–86. PMID 9525934. doi:10.1074/jbc.273.14.8278.
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外部連結

醫學主題詞表（MeSH）：ID3+protein,+human

ID3 (基因)引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000283060、ENSG00000117318 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000007872 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1628620-5] Ellmeier W, Aguzzi A, Kleiner E, Kurzbauer R, Weith A. . EMBO J. Aug 1992, 11 (7): 2563–71. PMC 556731 . PMID 1628620.

[entrez-6] . （原始内容存档于2019-10-17）.

[pmid9525934-7] Deed RW, Jasiok M, Norton JD. . J. Biol. Chem. Apr 1998, 273 (14): 8278–86. PMID 9525934. doi:10.1074/jbc.273.14.8278.

[pmid9242638-8] Langlands K, Yin X, Anand G, Prochownik EV. . J. Biol. Chem. Aug 1997, 272 (32): 19785–93. PMID 9242638. doi:10.1074/jbc.272.32.19785.

[pmid20020054-9] Farioli-Vecchioli S, Saraulli D, Costanzi M, Leonardi L, Cinà I, Micheli L, Nutini M, Longone P, Oh SP, Cestari V, Tirone F. Okazawa H , 编. . PLoS ONE. 2009, 4 (12): e8339. PMC 2791842 . PMID 20020054. doi:10.1371/journal.pone.0008339.