MKL1

Megakaryoblastic leukemia (translocation) 1; 巨核细胞白血病（易位）1
	Rendering based on PDB 2KVU.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	2KVU, 2KW9
标识
代号	MKL1; BSAC; MAL; MRTF-A
扩展标识	遗传学：606078 鼠基因：2384495 同源基因：32487 GeneCards: MKL1 Gene
基因本体论描述
分子功能	· transcription regulatory region sequence-specific DNA binding; · sequence-specific DNA binding transcription factor activity; · transcription coactivator activity; · actin binding; · actin monomer binding; · protein binding; · leucine zipper domain binding;
细胞成分	· nucleus; · nucleolus; · cytoplasm;
生物过程	· transcription, DNA-templated; · positive regulation of transcription via serum response element binding; · negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; · positive regulation of transcription from RNA polymerase II promoter; · smooth muscle cell differentiation; · negative regulation of apoptotic signaling pathway;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体

MKL/megakaryoblastic leukemia 1（巨核细胞白血病）是一种由人类基因 MKL1 编码的蛋白质。[1][2][3][4]

此基因编码的蛋白能与转录因子心肌素（英語：，一种调控平滑肌细胞分化的关键转录因子）相互作用。此蛋白主要存在于细胞核中，帮助信号从细胞质到细胞核的转导。在一个特异的染色体易位中，此基因会与1号染色体上的RNA结合基序蛋白15基因融合，这一易位与急性巨核细胞白血病相关。[4]

参考文献

Ma Z, Morris SW, Valentine V, Li M, Herbrick JA, Cui X, Bouman D, Li Y, Mehta PK, Nizetic D, Kaneko Y, Chan GC, Chan LC, Squire J, Scherer SW, Hitzler JK. . Nat Genet. Jun 2001, 28 (3): 220–1. PMID 11431691. doi:10.1038/90054.
Sasazuki T, Sawada T, Sakon S, Kitamura T, Kishi T, Okazaki T, Katano M, Tanaka M, Watanabe M, Yagita H, Okumura K, Nakano H. . J Biol Chem. Aug 2002, 277 (32): 28853–60. PMID 12019265. doi:10.1074/jbc.M203190200.
Du KL, Chen M, Li J, Lepore JJ, Mericko P, Parmacek MS. . J Biol Chem. Apr 2004, 279 (17): 17578–86. PMID 14970199. doi:10.1074/jbc.M400961200.
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延伸阅读

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[pmid11431691-1] Ma Z, Morris SW, Valentine V, Li M, Herbrick JA, Cui X, Bouman D, Li Y, Mehta PK, Nizetic D, Kaneko Y, Chan GC, Chan LC, Squire J, Scherer SW, Hitzler JK. . Nat Genet. Jun 2001, 28 (3): 220–1. PMID 11431691. doi:10.1038/90054.

[pmid12019265-2] Sasazuki T, Sawada T, Sakon S, Kitamura T, Kishi T, Okazaki T, Katano M, Tanaka M, Watanabe M, Yagita H, Okumura K, Nakano H. . J Biol Chem. Aug 2002, 277 (32): 28853–60. PMID 12019265. doi:10.1074/jbc.M203190200.

[pmid14970199-3] Du KL, Chen M, Li J, Lepore JJ, Mericko P, Parmacek MS. . J Biol Chem. Apr 2004, 279 (17): 17578–86. PMID 14970199. doi:10.1074/jbc.M400961200.

[entrez-4] .