SIBLING蛋白

SIBLING蛋白是一種非胶原蛋白，是骨和牙本质的细胞外基质的组成部分。其英文部分「SIBLING」为小整联N-连接糖蛋白（small integrin-binding ligand, N-linked glycoprotein）的缩写。有证据表明SIBLING蛋白在这些组织的矿化中起关键作用。[1]

下列蛋白质属于SIBLING蛋白：[1][2]

  1. 骨桥蛋白 Osteopontin (OPN) 或分泌磷蛋白1 Secreted phosphoprotein 1 (SPP1)；
  2. 骨涎蛋白 bone sialoprotein （BSP）；
  3. 牙本质基质蛋白1 Dentin matrix protein 1 (DMP1)；
  4. 牙本质唾液酸磷酸蛋白 Dentin sialophosphoprotein (DSPP)；
  5. 基质细胞外磷酸糖蛋白 Matrix extracellular phosphoglycoprotein (MEPE)。

编码SIBLING家族蛋白的基因位于人类染色体4q21-23上。[3]

参考文献
  1. Qin, C.; Baba, O.; Butler, W.T. (2004). "Post-Translational Modifications of Sibling Proteins and Their Roles in Osteogenesis and Dentinogenesis". Critical Reviews in Oral Biology & Medicine. 15 (3): 126–36. doi:10.1177/154411130401500302. PMID 15187031.
  2. Chaplet, M; De Leval, L; Waltregny, D; Detry, C; Fornaciari, G; Bevilacqua, G; Fisher, LW; Castronovo, V; Bellahcène, A (2003). "Dentin Matrix Protein 1 is Expressed in Human Lung Cancer". Journal of Bone and Mineral Research. 18 (8): 1506–12. doi:10.1359/jbmr.2003.18.8.1506. PMID 12929940. INIST:15005341.
  3. Rittling, Susan R.; Denhardt, David T. (1999). "Osteopontin Function in Pathology: Lessons from Osteopontin-Deficient Mice". Nephron Experimental Nephrology. 7 (2): 103–13. doi:10.1159/000020591. PMID 10213864.
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