SS18

Synovial sarcoma translocation, chromosome 18; 第18染色体，滑液肉瘤易位
标识
代号	SS18; SSXT; SYT
扩展标识	遗传学：600192 鼠基因：107708 同源基因：38080 GeneCards: SS18 Gene
基因本体论描述
分子功能	· protein binding; · ligand-dependent nuclear receptor transcription coactivator activity;
细胞成分	· nucleus; · cytoplasmic microtubule; · npBAF complex;
生物过程	· microtubule cytoskeleton organization; · cell morphogenesis; · transcription, DNA-templated; · intracellular signal transduction; · response to drug; · positive regulation of transcription from RNA polymerase II promoter; · ephrin receptor signaling pathway; · neuronal stem cell maintenance;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体

SSXT蛋白，是一类蛋白。在人体是由SS18基因编码[1][2][3]。

结构

SS18是一种人类SWI/SNF染色质重塑复合物[4][5][6]。

临床意义

SS18参与到染色体易位中，并常见于滑膜肉瘤[7]。

交互作用

SS18与以下蛋白质产生相互作用：

EP300[8]
MLLT10[9]
SMARCA2[6]
SMARCB1[5]

参考

Shipley JM, Clark J, Crew AJ, Birdsall S, Rocques PJ, Gill S, Chelly J, Monaco AP, Abe S, Gusterson BA. . Oncogene. May 1994, 9 (5): 1447–53. PMID 8152806.
Clark J, Rocques PJ, Crew AJ, Gill S, Shipley J, Chan AM, Gusterson BA, Cooper CS. . Nature Genetics. Aug 1994, 7 (4): 502–8. PMID 7951320. doi:10.1038/ng0894-502.
de Bruijn DR, Geurts van Kessel A. . Cytogenetic and Genome Research. 2006, 112 (3-4): 222–6. PMID 16484776. doi:10.1159/000089874.
Middeljans E, Wan X, Jansen PW, Sharma V, Stunnenberg HG, Logie C. . PLOS ONE. 2012, 7 (3): e33834. PMC 3307773 . PMID 22442726. doi:10.1371/journal.pone.0033834.
Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG. . The Journal of Biological Chemistry. Feb 2002, 277 (7): 5498–505. PMID 11734557. doi:10.1074/jbc.M108702200.
Perani M, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH. . Oncogene. Nov 2003, 22 (50): 8156–67. PMID 14603256. doi:10.1038/sj.onc.1207031.
Yang K, Lui WO, Xie Y, Zhang A, Skytting B, Mandahl N, Larsson C, Larsson O. . Oncogene. Jun 2002, 21 (26): 4181–90. PMID 12037676. doi:10.1038/sj.onc.1205569.
Eid JE, Kung AL, Scully R, Livingston DM. . Cell. Sep 2000, 102 (6): 839–48. PMID 11030627. doi:10.1016/S0092-8674(00)00072-6.
de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A. . Oncogene. May 2001, 20 (25): 3281–9. PMID 11423977. doi:10.1038/sj.onc.1204419.

延伸阅读

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[pmid8152806-1] Shipley JM, Clark J, Crew AJ, Birdsall S, Rocques PJ, Gill S, Chelly J, Monaco AP, Abe S, Gusterson BA. . Oncogene. May 1994, 9 (5): 1447–53. PMID 8152806.

[pmid7951320-2] Clark J, Rocques PJ, Crew AJ, Gill S, Shipley J, Chan AM, Gusterson BA, Cooper CS. . Nature Genetics. Aug 1994, 7 (4): 502–8. PMID 7951320. doi:10.1038/ng0894-502.

[pmid16484776-3] Bruijn DR, Geurts van Kessel A. . Cytogenetic and Genome Research. 2006, 112 (3-4): 222–6. PMID 16484776. doi:10.1159/000089874.

[pmid22442726-4] Middeljans E, Wan X, Jansen PW, Sharma V, Stunnenberg HG, Logie C. . PLOS ONE. 2012, 7 (3): e33834. PMC 3307773 . PMID 22442726. doi:10.1371/journal.pone.0033834.

[pmid11734557-5] Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG. . The Journal of Biological Chemistry. Feb 2002, 277 (7): 5498–505. PMID 11734557. doi:10.1074/jbc.M108702200.

[pmid14603256-6] Perani M, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH. . Oncogene. Nov 2003, 22 (50): 8156–67. PMID 14603256. doi:10.1038/sj.onc.1207031.

[pmid12037676-7] Yang K, Lui WO, Xie Y, Zhang A, Skytting B, Mandahl N, Larsson C, Larsson O. . Oncogene. Jun 2002, 21 (26): 4181–90. PMID 12037676. doi:10.1038/sj.onc.1205569.

[pmid11030627-8] Eid JE, Kung AL, Scully R, Livingston DM. . Cell. Sep 2000, 102 (6): 839–48. PMID 11030627. doi:10.1016/S0092-8674(00)00072-6.

[pmid11423977-9] Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A. . Oncogene. May 2001, 20 (25): 3281–9. PMID 11423977. doi:10.1038/sj.onc.1204419.