SUZ12

Zeste 12同源物（果蝇属）抑制因子
标识
代号	SUZ12; CHET9; JJAZ1
扩展标识	遗传学：606245 鼠基因：1261758 同源基因：32256 GeneCards: SUZ12 Gene
基因本体论描述
分子功能	· chromatin binding; · protein binding; · methylated histone residue binding; · histone methyltransferase activity; · sequence-specific DNA binding; · metal ion binding;
细胞成分	· sex chromatin; · ESC/E(Z) complex;
生物过程	· negative regulation of transcription from RNA polymerase II promoter; · transcription, DNA-dependent; · positive regulation of cell proliferation; · histone ubiquitination; · negative regulation of cell differentiation;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体

多梳蛋白SUZ12是由人类SUZ12 基因所编码的蛋白质[1][2][3][4] 有报导称该锌指基因在子宫内膜基质肉瘤中位于常见染色体易位断裂点上。这些断裂点相互重组导致该基因与JAZF1两者发生融合。该基因编码的蛋白质在编码区域C端包含有一个锌指结构域。目前仍未明确该基因的特异性功能[4]。

作为多梳抑制复合物2（PRC2）的一部分，SUZ12可能与HOTAIR非编码RNA一起参与到染色质沉默之中，SUZ12利用其锌指结构域与RNA分子进行结合[5]。

参考文献

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深入阅读

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外部链接

FactorBook SUZ12

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[pmid8590280-1] Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N. . DNA Res. Mar 1996, 2 (4): 167–74, 199–210. PMID 8590280. doi:10.1093/dnares/2.4.167.

[pmid11371647-2] Koontz JI, Soreng AL, Nucci M, Kuo FC, Pauwels P, van Den Berghe H, Dal Cin P, Fletcher JA, Sklar J. . Proc Natl Acad Sci U S A. May 2001, 98 (11): 6348–53. PMC 33471 . PMID 11371647. doi:10.1073/pnas.101132598.

[pmid18784248-3] Ross PJ, Ragina NP, Rodriguez RM, Iager AE, Siripattarapravat K, Lopez-Corrales N, Cibelli JB. . Reproduction. Dec 2008, 136 (6): 777–85. PMID 18784248. doi:10.1530/REP-08-0045.

[entrez-4] . （原始内容存档于2010-03-07）.

[Rinn-5] Rinn JL; Kertesz M; Wang JK; et al. . Cell. June 2007, 129 (7): 1311–23 [2010-07-20]. PMC 2084369 . PMID 17604720. doi:10.1016/j.cell.2007.05.022. （原始内容存档于2019-02-17）. 已忽略未知参数|author-separator= (帮助)