冯·布劳恩反应

冯·布劳恩反应（德語：），是叔胺与溴化氰反应，得到相应的氰胺衍生物。[1] 例如，从1-二甲氨基萘合成N-萘基-N-甲基氰胺：[2]

冯·布劳恩反应

反应机理

胺亲核进攻溴化氰，得季铵离子，然后离去的溴离子再亲核进攻季铵离子，得氰胺和溴代烃。[3]

参见

参考资料
  1. Von Braun, Heider, and Muller, Ber., 51, 281 (1918).
  2. Organic Syntheses, Coll. Vol. 3, p.608 (1955); Vol. 27, p.56 (1947). http://www.orgsynth.org/orgsyn/pdfs/CV3P0608.pdf （页面存档备份，存于）
  3. March, Jerry (1985). Advanced Organic Chemistry, Reactions, Mechanisms and Structure, third Edition, John Wiley & Sons. ISBN 0-471-85472-7.
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