Zincke硝化反应

Zincke硝化反应（Zincke nitration），又作Zinke硝化反应，由 Theodor Zincke 首先报道。

溴代酚类或甲酚类用亚硝酸或亚硝酸钠处理，溴被硝基取代，得到相应的芳香硝基化合物。[1]

此反应是一种亲核芳香取代反应。

例子

1、[2]


Zincke硝化


2、[3]


Zincke硝化

参见

参考资料
  1. Zincke, Th., J . prakt. Chem., [2] 61, 563 (1900).
  2. The Nitration of Brominated Fluorophenols by the Zincke Method L. Chas. Raiford and Arthur L. LeRosen J. Am. Chem. Soc.; 1944; 66(11) pp 1872 - 1873; doi:10.1021/ja01239a020
  3. Behavior of Mixed Halogenated Phenols in the Zincke Method of Nitration L. Chas. Raiford and Glen R. Miller J. Am. Chem. Soc.; 1933; 55(5) pp 2125 - 2131; doi:10.1021/ja01332a059
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