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The year 1549 in science and technology included some events, a few of which are listed here.
Births
- November 30 – Henry Savile, English polymath and benefactor (died 1622)
- Michiel Coignet, Flemish engineer, cosmographer, mathematician and scientific instrument-maker (died 1623)
- Nikola Vitov Gučetić, Ragusan polymath (died 1610)
Deaths
- April – Andrew Boorde, English physician and traveller (born 1490)
- August – Jacob Ziegler, German geographer (born c. 1470/1)
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