The knockout stage of the 2005–06 UEFA Cup began on 15 February 2006, and concluded with the final at the Philips Stadion in Eindhoven, Netherlands, on 10 May 2006. The final phase involved the 24 teams that finished in the top three in each group in the group stage and the eight teams that finished in third place in the UEFA Champions League group stage.

Each tie in the final phase, apart from the final, was played over two legs, with each team playing one leg at home. The team that had the higher aggregate score over the two legs progressed to the next round. In the event that aggregate scores finished level, the team that scored more goals away from home over the two legs progressed. If away goals are also equal, 30 minutes of extra time were played. If goals were scored during extra time and the aggregate score was still level, the visiting team qualified by virtue of more away goals scored. If no goals were scored during extra time, there would be a penalty shootout after extra time.

In the final, the tie was played over just one leg at a neutral venue. If scores were level at the end of normal time in the final, extra time was played, followed by penalties if scores had remained tied.

Seedings

In the draw for the Round of 32, matches were played between the winner of one group and the third-placed team of a different group, and between the runners-up of one group and the third-placed team from a Champions League group. The only restriction on the drawing of teams in the Round of 32 was that the teams must not be from the same national association or have played in the same group in the group stages. From the Round of 16 onwards, these restrictions did not apply.

Pot 1 – UEFA Cup Group Stage Winners
France Monaco
Italy Palermo
Romania Steaua București
England Middlesbrough
France Strasbourg
France Marseille
Romania Rapid București
Spain Sevilla
Pot 2 – UEFA Cup Group Stage Runners-up
Germany Hamburg
Spain Espanyol
France Lens
Netherlands AZ
Italy Roma
Bulgaria Levski Sofia
Ukraine Shakhtar Donetsk
Russia Zenit Saint Petersburg
Pot 3 – UEFA Cup Group Stage Third Place
Czech Republic Slavia Prague
Russia Lokomotiv Moscow
Germany Hertha BSC
Bulgaria Litex Lovech
Switzerland Basel
Netherlands Heerenveen
Germany Stuttgart
England Bolton Wanderers
Pot 4 – Champions League Group Stage Third Place
Belgium Club Brugge
Switzerland Thun
Italy Udinese
France Lille
Germany Schalke 04
Norway Rosenborg
Spain Real Betis
Slovakia Artmedia

Bracket

Round of 32 Round of 16 Quarter-finals Semi-finals Final
Germany Hertha BSC 0 0 0
Romania Rapid București 1 2 3 Romania Rapid București (a) 2 1 3
Switzerland Thun 1 0 1 Germany Hamburg 0 3 3
Germany Hamburg 0 2 2 Romania Rapid București 1 0 1
Netherlands Heerenveen 1 1 2 Romania Steaua București (a) 1 0 1
Romania Steaua București 3 0 3 Romania Steaua București 0 3 3
Spain Real Betis 2 1 3 Spain Real Betis 0 0 0
Netherlands AZ 0 2 2 Romania Steaua București 1 2 3
Switzerland Basel 1 1 2 England Middlesbrough 0 4 4
France Monaco 0 1 1 Switzerland Basel 2 2 4
Bulgaria Litex Lovech 0 0 0 France Strasbourg 0 2 2
France Strasbourg 2 0 2 Switzerland Basel 2 1 3
Germany Stuttgart 1 1 2 England Middlesbrough 0 4 4
England Middlesbrough (a) 2 0 2 England Middlesbrough (a) 1 1 2
Belgium Club Brugge 1 1 2 Italy Roma 0 2 2
Italy Roma 2 2 4 England Middlesbrough 0
Italy Udinese 3 0 3 Spain Sevilla 4
France Lens 0 1 1 Italy Udinese 0 1 1
Slovakia Artmedia Bratislava 0 0 0 Bulgaria Levski Sofia 0 2 2
Bulgaria Levski Sofia 1 2 3 Bulgaria Levski Sofia 1 1 2
Czech Republic Slavia Prague 2 0 2 Germany Schalke 04 3 1 4
Italy Palermo (a) 1 1 2 Italy Palermo 1 0 1
Germany Schalke 04 2 3 5 Germany Schalke 04 0 3 3
Spain Espanyol 1 0 1 Germany Schalke 04 0 0 0
France Lille 3 0 3 Spain Sevilla 0 1 1
Ukraine Shakhtar Donetsk 2 0 2 France Lille 1 0 1
Russia Lokomotiv Moscow 0 0 0 Spain Sevilla 0 2 2
Spain Sevilla 1 2 3 Spain Sevilla 4 1 5
England Bolton Wanderers 0 1 1 Russia Zenit Saint Petersburg 1 1 2
France Marseille 0 2 2 France Marseille 0 1 1
Norway Rosenborg 0 1 1 Russia Zenit Saint Petersburg 1 1 2
Russia Zenit Saint Petersburg 2 2 4

Round of 32

The top three teams from each group were joined by the eight teams which finished third in their groups in the Champions League.

Team 1 Agg.Tooltip Aggregate score Team 2 1st leg 2nd leg
Litex Lovech Bulgaria 0–2 France Strasbourg 0–2 0–0
Stuttgart Germany 2–2 (a) England Middlesbrough 1–2 1–0
Slavia Prague Czech Republic 2–2 (a) Italy Palermo 2–1 0–1
Heerenveen Netherlands 2–3 Romania Steaua București 1–3 1–0
Lokomotiv Moscow Russia 0–3 Spain Sevilla 0–1 0–2
Bolton Wanderers England 1–2 France Marseille 0–0 1–2
Hertha BSC Germany 0–3 Romania Rapid București 0–1 0–2
Basel Switzerland 2–1 France Monaco 1–0 1–1
Udinese Italy 3–1 France Lens 3–0 0–1
Rosenborg Norway 1–4 Russia Zenit Saint Petersburg 0–2 1–2
Club Brugge Belgium 2–4 Italy Roma 1–2 1–2
Schalke 04 Germany 5–1 Spain Espanyol 2–1 3–0
Lille France 3–2 Ukraine Shakhtar Donetsk 3–2 0–0
Thun Switzerland 1–2 Germany Hamburg 1–0 0–2
Real Betis Spain 3–2 Netherlands AZ 2–0 1–2(aet)
Artmedia Bratislava Slovakia 0–3 Bulgaria Levski Sofia 0–1 0–2

First leg

Litex Lovech Bulgaria0–2France Strasbourg
Report Le Pen 2'
Diané 82'
Attendance: 3,546
Stuttgart Germany1–2England Middlesbrough
Ljuboja 86' Report Hasselbaink 20'
Parnaby 46'
Attendance: 18,638
Slavia Prague Czechoslovakia2–1Italy Palermo
Jarolím 28'
Piták 48'		 Report Conteh 40'
Attendance: 6,706
Referee: Anton Genov (Bulgaria)
Heerenveen Netherlands1–3Romania Steaua București
Bruggink 24' Report Dică 29'
Goian 76'
Paraschiv 78'
Attendance: 20,500
Lokomotiv Moscow Russia0–1Spain Sevilla
Report López 75'
Attendance: 10,223
Bolton Wanderers England0–0France Marseille
Report
Attendance: 19,288
Hertha BSC Germany0–1Romania Rapid București
Report Negru 68' (pen.)
Attendance: 13,430
Basel Switzerland1–0France Monaco
Degen 78' Report
Attendance: 14,143
Udinese Italy3–0France Lens
Di Natale 35'
Barreto 61', 82'		 Report
Attendance: 6,928
Rosenborg Norway0–2Russia Zenit Saint Petersburg
Report Arshavin 22'
Kerzhakov 32'
Attendance: 11,082
Club Brugge Belgium1–2Italy Roma
Portillo 61' Report Vanaudenaerde 44' (o.g.)
Perrotta 74'
Attendance: 27,138
Schalke 04 Germany2–1Spain Espanyol
Bordon 67'
Ernst 88'		 Report García 34'
Attendance: 53,642
Lille France3–2Ukraine Shakhtar Donetsk
Fauvergue 19'
Dernis 57'
Odemwingie 77'		 Report Brandão 89'
Marica 90+1'
Attendance: 13,644
Thun Switzerland1–0Germany Hamburg
Adriano 30' Report
Attendance: 18,354
Real Betis Spain2–0Netherlands AZ
Tardelli 70'
Robert 79'		 Report
Attendance: 11,112

Second leg

Strasbourg France0–0Bulgaria Litex Lovech
Report
Attendance: 9,760

Strasbourg won 2–0 on aggregate.

Middlesbrough England0–1Germany Stuttgart
Report Tiffert 13'
Attendance: 24,018

2–2 on aggregate. Middlesbrough won on away goals.

Palermo Italy1–0Czech Republic Slavia Prague
Godeas 51' Report
Attendance: 8,063

2–2 on aggregate. Palermo won on away goals.

Steaua București Romania0–1Netherlands Heerenveen
Report Bruggink 85'
Attendance: 46,697
Referee: Jaroslav Jára (Czech Republic)

Steaua București won 3–2 on aggregate.

Sevilla Spain2–0Russia Lokomotiv Moscow
Maresca 34'
Puerta 90'		 Report
Attendance: 19,970
Referee: Alain Sars (France)

Sevilla won 3–0 on aggregate.

Marseille France2–1England Bolton Wanderers
Ribéry 45+2'
Ben Haim 68' (o.g.)		 Report Giannakopoulos 25'
Attendance: 38,351

Marseille won 2–1 on aggregate.

Rapid București won 3–0 on aggregate.

Monaco France1–1Switzerland Basel
Vieri 21' (pen.) Report Majstorović 56'
Attendance: 11,955

Basel won 2–1 on aggregate.

Lens France1–0Italy Udinese
Frau 55' Report
Attendance: 26,292

Udinese won 3–1 on aggregate.

Zenit Saint Petersburg won 4–1 on aggregate.

Roma Italy2–1Belgium Club Brugge
Mancini 55'
Bovo 71'		 Report Verheyen 60'
Attendance: 15,209

Roma won 4–2 on aggregate.

Espanyol Spain0–3Germany Schalke 04
Report Kurányi 54'
Sand 70'
Lincoln 73'
Attendance: 18,100

Schalke 04 won 5–1 on aggregate.

Shakhtar Donetsk Ukraine0–0France Lille
Report
Attendance: 23,250

Lille won 3–2 on aggregate.

Hamburg Germany2–0Switzerland Thun
Van Buyten 2', 33' Report
Attendance: 40,254
Referee: Alon Yefet (Israel)

Hamburg won 2–1 on aggregate.

AZ Netherlands2–1 (a.e.t.)Spain Real Betis
Arveladze 26'
Jaliens 35'		 Report Melli 99'
Attendance: 8,073

Real Betis won 3–2 on aggregate.

Levski Sofia Bulgaria2–0Slovakia Artmedia Bratislava
Angelov 14', 27' Report
Attendance: 23,441

Levski Sofia won 3–0 on aggregate.

Round of 16

Team 1 Agg.Tooltip Aggregate score Team 2 1st leg 2nd leg
Rapid București Romania 3–3 (a) Germany Hamburg 2–0 1–3
Basel Switzerland 4–2 France Strasbourg 2–0 2–2
Middlesbrough England 2–2 (a) Italy Roma 1–0 1–2
Steaua București Romania 3–0 Spain Real Betis 0–0 3–0
Palermo Italy 1–3 Germany Schalke 04 1–0 0–3
Marseille France 1–2 Russia Zenit Saint Petersburg 0–1 1–1
Udinese Italy 1–2 Bulgaria Levski Sofia 0–0 1–2
Lille France 1–2 Spain Sevilla 1–0 0–2

First leg

Basel Switzerland2–0France Strasbourg
Delgado 86'
Kuzmanović 89'		 Report
Attendance: 14,243
Middlesbrough England1–0Italy Roma
Yakubu 12' (pen.) Report
Attendance: 25,354
Referee: Alain Sars (France)
Steaua București Romania0–0Spain Real Betis
Report
Attendance: 45,003
Palermo Italy1–0Germany Schalke 04
Brienza 15' Report
Attendance: 10,581
Marseille France0–1Russia Zenit Saint Petersburg
Report Arshavin 51'
Attendance: 21,500
Udinese Italy0–0Bulgaria Levski Sofia
Report
Attendance: 7,650
Lille France1–0Spain Sevilla
Dernis 24' Report
Attendance: 11,009

Second leg

Hamburg Germany3–1Romania Rapid București
Lauth 24'
Barbarez 36'
Van der Vaart 62'		 Report Buga 51'
Attendance: 37,886

3–3 on aggregate, Rapid București won on away goals.

Strasbourg France2–2Switzerland Basel
Carlier 11'
Kanté 78'		 Report Eduardo 3', 26'
Attendance: 7,322

Basel won 4–2 on aggregate.

Roma Italy2–1England Middlesbrough
Mancini 43', 66' (pen.) Report Hasselbaink 32'
Attendance: 32,642

2–2 on aggregate, Middlesbrough won on away goals.

Real Betis Spain0–3Romania Steaua București
Report Nicoliță 54', 82'
Iacob 78'
Attendance: 16,861

Steaua București won 3–0 on aggregate.

Schalke 04 Germany3–0Italy Palermo
Kobiashvili 44' (pen.)
Larsen 72'
Azaouagh 80'		 Report
Attendance: 52,151
Referee: Graham Poll (England)

Schalke 04 won 3–1 on aggregate.

Zenit Saint Petersburg Russia1–1France Marseille
Kerzhakov 69' Report Déhu 74'
Attendance: 18,902

Zenit Saint Petersburg won 2–1 on aggregate.

Levski Sofia Bulgaria2–1Italy Udinese
Borimirov 51'
Tomašić 63'		 Report Tissone 22'
Attendance: 33,218

Levski Sofia won 2–1 on aggregate.

Sevilla Spain2–0France Lille
Kanouté 29'
Luís Fabiano 45+2'		 Report
Attendance: 33,660
Referee: Mike Riley (England)

Sevilla won 2–1 on aggregate.

Quarter-finals

Team 1 Agg.Tooltip Aggregate score Team 2 1st leg 2nd leg
Sevilla Spain 5–2 Russia Zenit Saint Petersburg 4–1 1–1
Basel Switzerland 3–4 England Middlesbrough 2–0 1–4
Rapid București Romania 1–1 (a) Romania Steaua București 1–1 0–0
Levski Sofia Bulgaria 2–4 Germany Schalke 04 1–3 1–1

First leg

Sevilla Spain4–1Russia Zenit St Petersburg
Saviola 14', 80'
Martí 56' (pen.)
Adriano 90+3'		 Report Kerzhakov 45'
Attendance: 28,633
Basel Switzerland2–0England Middlesbrough
Delgado 43'
Degen 45+1'		 Report
Attendance: 23,639
Levski Sofia Bulgaria1–3Germany Schalke 04
Borimirov 6' Report Varela 48'
Lincoln 69'
Asamoah 79'
Attendance: 35,792
Referee: Mike Riley (English)

Second leg

Zenit Saint Petersburg Russia1–1Spain Sevilla
Hyun 50' Report Kepa 66'
Attendance: 17,028

Sevilla won 5–2 on aggregate.

Middlesbrough England4–1Switzerland Basel
Viduka 33', 57'
Hasselbaink 79'
Maccarone 90'		 Report Eduardo 23'
Attendance: 24,521

Middlesbrough won 4–3 on aggregate.

1–1 on aggregate. Steaua București won on away goals.

Schalke 04 Germany1–1Bulgaria Levski Sofia
Lincoln 58' Report Angelov 24'
Attendance: 52,973

Schalke 04 won 4–2 on aggregate.

Semi-finals

Team 1 Agg.Tooltip Aggregate score Team 2 1st leg 2nd leg
Schalke 04 Germany 0–1 Spain Sevilla 0–0 0–1 (aet)
Steaua București Romania 3–4 England Middlesbrough 1–0 2–4

First leg

Schalke 04 Germany0–0Spain Sevilla
Report
Attendance: 53,551
Steaua București Romania1–0England Middlesbrough
Dică 30' Report
Attendance: 40,482

Second leg

Sevilla Spain1–0 (a.e.t.)Germany Schalke 04
Puerta 101' Report
Attendance: 39,475

Sevilla won 1–0 on aggregate.

Middlesbrough England4–2Romania Steaua București
Maccarone 33', 89'
Viduka 64'
Riggott 73'		 Report Dică 16'
Goian 24'
Attendance: 34,622

Middlesbrough won 4–3 on aggregate.

Final

Middlesbrough England0–4Spain Sevilla
Report Luís Fabiano 27'
Maresca 78', 84'
Kanouté 89'
Attendance: 32,100
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