Milestones

• Maria Sharapova recorded her 100th Grand Slam match victory with a 6–0, 6–0 defeat of wildcard Beatrice Capra in the third round.^[2]
• Kim Clijsters became the first woman since Venus Williams in 2000–1 to successfully defend her US Open title, by defeating Vera Zvonareva in the final.^[3] The final lasted just under one hour with Clijsters winning 6–2, 6–1.
• Rafael Nadal defeated Novak Djokovic 6–4, 5–7, 6–4, 6–2 in the men's final, and in doing so, completed his Golden Career Grand Slam.^[4]

Serena Williams' withdrawal

Vera Zvonareva reached her first US Open final by defeating top seed Caroline Wozniacki in the semi-finals.

Three-time champion and World No. 1 Serena Williams officially announced her withdrawal from the US Open on August 20 due to foot surgery.^[5] Her withdrawal also meant that she and older sister Venus could not pair up to defend the doubles title they won in 2009,^[6] and allowed WTA No. 2 Caroline Wozniacki to be installed as the top seed for the tournament,^[7] where she was defeated in the semi-finals by Vera Zvonareva. It was the first time since 2003 in which Serena Williams was forced to miss her national championships due to injury, the first Grand Slam tournament she missed through injury since Wimbledon in 2006, the first time since the 2007 Australian Open in which the women's World No. 1 missed a Grand Slam tournament and the first time in the WTA's 35-year rankings history that the World No. 1 missed the US Open.^[8]

Other notable withdrawals included two-time champion Justine Henin, as well as men's defending champion Juan Martín del Potro, Tommy Haas, Jo-Wilfried Tsonga, Ivo Karlović and Mario Ančić. Venus Williams, Maria Sharapova, Ana Ivanovic, Kim Clijsters and John Isner had all been in doubt after suffering minor injuries during lead-up tournaments but all were cleared to play.^[9]

Victoria Azarenka collapses

In a second round match played in 104 °F (40 °C) heat, Belarusian 10th seed Victoria Azarenka collapsed whilst trailing Gisela Dulko 1–5 in the first set. Azarenka was subsequently taken to hospital in a wheelchair where she was diagnosed with mild concussion and later released a statement saying that a mishap in the gym, and not the heat, caused her to collapse during the match.^[10][11] Her second round retirement represented her worst ever performance at the US Open, having never previously fallen before the third round. It was also the second time she was forced to retire from a match at a Major, when she retired in near identical circumstances against Serena Williams at the 2009 Australian Open.

Spanish performance

The men's tournament was well known for the excellent performances of Spanish players.^[12][13] Of the sixteen Spaniards that started in the 128-man draw, six of them reached the fourth round: Rafael Nadal, Fernando Verdasco, Tommy Robredo, David Ferrer, Feliciano López and Albert Montañés. There were two all-Spanish fourth round matches, guaranteeing two Spaniards in the quarter-finals: Nadal vs. López and Ferrer vs. Verdasco (the latter winning in a final set tiebreak). In a rematch of their 2009 Australian Open semi-final, Nadal defeated Verdasco in straight sets in the all-Spanish quarter-final, and went on to become the first Spaniard since Manuel Orantes in 1975 to win the US Open.^[14]

Men's singles

Rafael Nadal def. Novak Djokovic, 6–4, 5–7, 6–4, 6–2

• It was Nadal's 6th title of the year and 42nd of his career. It was his 3rd slam of the year, first US Open, and 9th slam of his career.

Women's singles

Kim Clijsters def. Vera Zvonareva, 6–2, 6–1

• It was Clijsters' 4th title of the year and 39th of her career. It was her 3rd career Grand Slam singles title and her 3rd and last at the US Open.

Men's doubles

Bob Bryan / Mike Bryan def. Rohan Bopanna / Aisam-ul-Haq Qureshi, 7–6^(7–5), 7–6^(7–4).

• It was the Bryan's ninth grand slam men's doubles title for their careers, and the third US Open crown along with 2005 and 2008. This was Bob's 65th title of his career and the 67th title of Mike's career.

Women's doubles

Vania King / Yaroslava Shvedova def. Liezel Huber / Nadia Petrova, 2–6, 6–4, 7–6^(7–4)

• This was the pair of King and Shvedova second women's grand slam doubles title of the year and of their careers to go along with the 2010 Wimbledon crown. This was King's eleventh women's doubles title of her career and Shvedova's third career women's doubles victory.

Mixed doubles

Liezel Huber / Bob Bryan def. Květa Peschke / Aisam-ul-Haq Qureshi, 6–4, 6–4.

• This victory was the second joint title in a grand slam tournament for the pair of Huber and Bryan, which they won the 2009 French Open together. This was Huber's second mixed double slam, which all were won with Bob, but this was Bob Bryan seventh mixed doubles title for his career. This was the first US Open title for Huber in mixed doubles, but this was Bob's fourth mixed doubles title for his career to go along with titles in 2003, 2004, and 2006.

Boys' singles

Jack Sock def. Denis Kudla, 3–6, 6–2, 6–2

Girls' singles

Daria Gavrilova def. Yulia Putintseva, 6–3, 6–2

Boys' doubles

Duilio Beretta / Roberto Quiroz def. Oliver Golding / Jiří Veselý, 6–1, 7–5

• It was their second Grand Slam Boys' Doubles title in the year after winning at the French Open.

Girls' doubles

Tímea Babos / Sloane Stephens def. An-Sophie Mestach / Silvia Njirić, walkover

• It was their third Grand Slam Girls' Doubles title in the year after winning at the French Open and at the Wimbledon Championships.

Wheelchair men's singles

Shingo Kunieda def. Nicolas Peifer, walkover

Wheelchair women's singles

Esther Vergeer def. Daniela Di Toro, 6–0, 6–0

Wheelchair men's doubles

Maikel Scheffers / Ronald Vink def. Nicolas Peifer / Jon Rydberg, 6–0, 6–0

Wheelchair women's doubles

Esther Vergeer / Sharon Walraven def. Daniela Di Toro / Aniek van Koot, 6–3, 6–3

Wheelchair quad singles

David Wagner def. Peter Norfolk, 6–0, 2–6, 6–3

Wheelchair quad doubles

Nick Taylor / David Wagner def. Johan Andersson / Peter Norfolk, 7–5, 7–6^(7–4)

Teams

Results

Men's singles

Seed	Rank	Player	Points before	Points defending	Points won	Points after	Status
1	1	Rafael Nadal	10,745	720	2,000	12,025	Champion, defeated Novak Djokovic [3]
2	2	Roger Federer	7,215	1,200	720	6,735	Semifinals lost to Novak Djokovic [3]
3	3	Novak Djokovic	6,665	720	1,200	7,145	Runner-up, lost to Rafael Nadal [1]
4	4	Andy Murray	5,125	180	90	5,035	Third round lost to Stan Wawrinka [25]
5	5	Robin Söderling	4,910	360	360	4,910	Quarterfinals lost to Roger Federer [2]
6	6	Nikolay Davydenko	4,285	180	45	4,150	Second round lost to Richard Gasquet
7	7	Tomáš Berdych	3,860	90	10	3,780	First round lost to Michaël Llodra
8	8	Fernando Verdasco	3,330	360	360	3,330	Quarterfinals lost to Rafael Nadal [1]
9	9	Andy Roddick	3,225	90	45	3,180	Second round lost to Janko Tipsarević
10	12	David Ferrer	3,065	45	180	3,200	Fourth round lost to Fernando Verdasco [8]
11	13	Marin Čilić	2,855	360	45	2,540	Second round lost to Kei Nishikori [Q]
12	14	Mikhail Youzhny	2,620	45	720	3,295	Semifinals lost to Rafael Nadal [1]
13	15	Jürgen Melzer	2,470	45	180	2,605	Fourth round lost to Roger Federer [2]
14	16	Nicolás Almagro	2,150	90	90	2,150	Third round lost to Sam Querrey [20]
15	17	Ivan Ljubičić	2,120	10	10	2,120	First round lost to Ryan Harrison [Q]
16	18	Marcos Baghdatis	2,095	75	10	2,030	First round lost to Arnaud Clément
17	19	Gaël Monfils	2,070	180	360	2,250	Quarterfinals lost to Novak Djokovic [3]
18	20	John Isner	1,805	180	90	1,715	Third round lost to Mikhail Youzhny [12]
19	21	Mardy Fish	1,751	0	180	1,931	Fourth round lost to Novak Djokovic [3]
20	22	Sam Querrey	1,705	90	180	1,795	Fourth round lost to Stan Wawrinka [25]
21	23	Albert Montañés	1,600	10	180	1,770	Fourth round lost to Robin Söderling [5]
22	24	Juan Carlos Ferrero	1,560	180	90	1,470	Third round lost to Jürgen Melzer [13]
23	25	Feliciano López	1,515	10	180	1,685	Fourth round lost to Rafael Nadal [1]
24	26	Ernests Gulbis	1,515	10	10	1,515	First round lost to Jérémy Chardy
25	27	Stan Wawrinka	1,510	10	360	1,860	Quarterfinals lost to Mikhail Youzhny [12]
26	28	Thomaz Bellucci	1,480	70	45	1,455	Second round lost to Kevin Anderson
27	29	Fernando González	1,340	360	10	990	First round retired against Ivan Dodig [Q]
28	30	Radek Štěpánek	1,320	180	10	1,150	First round lost to Julien Benneteau
29	31	Philipp Kohlschreiber	1,315	90	45	1,270	Second round lost to Gilles Simon
30	32	Juan Mónaco	1,235	10	10	1,235	First round lost to Peter Polansky [Q]
31	33	David Nalbandian	1,235	0	90	1,325	Third round lost to Fernando Verdasco [8]
32	34	Lleyton Hewitt	1,215	90	10	1,135	First round lost to Paul-Henri Mathieu

The following players would have been seeded, but they withdrew from the event.

Rank	Player	Points before	Points defending	Points after	Withdrawal reason
10	Juan Martín del Potro	3,170	2,000	1,170	Right wrist injury[29]
11	Jo-Wilfried Tsonga	3,085	180	2,905	Knee injury[30]

Women's singles

Seed	Rank	Player	Points before	Points defending	Points won	Points after	Status
1	2	Caroline Wozniacki	6,410	1,400	900	5,910	Semifinals lost to Vera Zvonareva [7]
2	3	Kim Clijsters	5,325	2,000	2,000	5,325	Champion, defeated Vera Zvonareva [7]
3	4	Venus Williams	5,176	280	900	5,796	Semifinals lost to Kim Clijsters [2]
4	5	Jelena Janković	5,145	100	160	5,205	Third round lost to Kaia Kanepi [31]
5	6	Samantha Stosur	4,550	100	500	4,950	Quarterfinals lost to Kim Clijsters [2]
6	7	Francesca Schiavone	4,450	280	500	4,670	Quarterfinals lost to Venus Williams [3]
7	8	Vera Zvonareva	4,430	280	1,400	5,550	Runner-up, lost to Kim Clijsters [2]
8	9	Li Na	4,015	500	5	3,520	First round lost to Kateryna Bondarenko
9	10	Agnieszka Radwańska	3,995	100	100	3,995	Second round lost to Peng Shuai
10	11	Victoria Azarenka	3,775	160	100	3,715	Second round retired against Gisela Dulko
11	13	Svetlana Kuznetsova	3,516	280	280	3,516	Fourth round lost to Dominika Cibulková
12	12	Elena Dementieva	3,765	100	280	3,945	Fourth round lost to Samantha Stosur [5]
13	14	Marion Bartoli	3,455	100	100	3,455	Second round lost to Virginie Razzano
14	17	Maria Sharapova	3,330	160	280	3,450	Fourth round lost to Caroline Wozniacki [1]
15	18	Yanina Wickmayer	3,310	900	280	2,690	Fourth round lost to Kaia Kanepi [31]
16	19	Shahar Pe'er	3,175	160	280	3,295	Fourth round lost to Venus Williams [3]
17	16	Nadia Petrova	3,345	280	5	3,070	First round lost to Andrea Petkovic
18	20	Aravane Rezaï	3,005	5	100	3,100	Second round lost to Beatrice Capra [WC]
19	21	Flavia Pennetta	2,905	500	160	2,565	Third round lost to Shahar Pe'er [16]
20	22	Anastasia Pavlyuchenkova	2,505	5	280	2,780	Fourth round lost to Francesca Schiavone [6]
21	23	Zheng Jie	2,351	160	100	2,291	Second round lost to Ana Ivanovic
22	24	María José Martínez Sánchez	2,285	160	100	2,225	Second round lost to Patty Schnyder
23	25	Maria Kirilenko	2,275	160	160	2,275	Third round lost to Svetlana Kuznetsova [11]
24	26	Daniela Hantuchová	2,045	280	160	1,925	Third round lost to Elena Dementieva [12]
25	27	Alexandra Dulgheru	2,005	5	160	2,160	Third round lost to Vera Zvonareva [7]
26	28	Lucie Šafářová	1,975	5	5	1,975	First round lost to Tamira Paszek [Q]
27	29	Petra Kvitová	1,869	280	160	1,749	Third round lost to Kim Clijsters [2]
28	30	Alisa Kleybanova	1,840	5	100	1,935	Second round lost to Sara Errani
29	33	Alona Bondarenko	1,723	100	160	1,783	Third round lost to Francesca Schiavone [6]
30	31	Yaroslava Shvedova	1,770	160	5	1,615	First round lost to Lourdes Domínguez Lino [Q]
31	32	Kaia Kanepi	1,725	5	500	2,220	Quarterfinals lost to Vera Zvonareva [7]
32	34	Tsvetana Pironkova	1,708	5	100	1,803	Second round lost to Mandy Minella [Q]

The following players would have been seeded, but they withdrew from the event.

Rank	Player	Points before	Points defending	Points after	Withdrawal reason
1	Serena Williams	7,895	900	6,995	Foot surgery[31]
15	Justine Henin	3,415	0	3,415	Right elbow injury[32]

Mixed doubles

1. Beatrice Capra / Jack Sock
2. Jill Craybas / Michael Russell
3. Nicole Gibbs / Sam Querrey
4. Carly Gullickson / Travis Parrott
5. Racquel Kops-Jones / Eric Butorac
6. Melanie Oudin / Ryan Harrison
7. Abigail Spears / Scott Lipsky