Players lost

• CB Mackensie Alexander - Declared for NFL Draft
• RB Zach Brooks
• DT Kevin Dodd
• S T. J. Green - Declared for NFL Draft
• LB B. J. Goodson
• S Jayron Kearse
• DE Shaq Lawson - Declared for NFL Draft
• WR Charone Peake
• DT D. J. Reader

Rankings

Coaching staff

Head coach Dabo Swinney added two new additions to the Tigers' coaching staff in late March 2016 with Mickey Conn and Kyle Richardson.^[3] Swinney hired former Grayson (GA) head coach Mickey Conn as a defensive analyst for the Tigers along with former Northwestern (SC) head coach Kyle Richardson, who will serve as the team's offensive analyst. Both coaches were extremely successful at their former high schools with a combined win–loss record of 195–61 and numerous championship titles.^[4][5]

Roster

Recruiting class

US college sports recruiting information for 2016 recruits
Name	Hometown	High school / college	Height	Weight	40‡	Commit date
Dexter Lawrence DT	Wake Forest, North Carolina	Wake Forest H.S.	6 ft 4 in (1.93 m)	327 lb (148 kg)	—	Dec 14, 2015
	Recruiting star ratings: Scout:   Rivals:   247Sports:    ESPN:
Tre Lamar LB	Roswell, Georgia	Roswell H.S.	6 ft 4 in (1.93 m)	240 lb (110 kg)	—	Jul 17, 2015
	Recruiting star ratings: Scout:   Rivals:   247Sports:    ESPN:
Rahshaun Smith LB	Bradenton, Florida	IMG Academy	6 ft 3 in (1.91 m)	239 lb (108 kg)	—	Jan 2, 2016
	Recruiting star ratings: Scout:   Rivals:   247Sports:    ESPN:
Tavien Feaster RB	Spartanburg, South Carolina	Spartanburg H.S.	5 ft 11 in (1.80 m)	196 lb (89 kg)	4.40	Feb 4, 2015
	Recruiting star ratings: Scout:   Rivals:   247Sports:    ESPN:
Trayvon Mullen DB	Coconut Creek, Florida	Coconut Creek H.S.	6 ft 2 in (1.88 m)	170 lb (77 kg)	—	Feb 3, 2016
	Recruiting star ratings: Scout:   Rivals:   247Sports:    ESPN:
Xavier Kelly DE	Wichita, Kansas	East H.S.	6 ft 4.5 in (1.94 m)	240 lb (110 kg)	—	Jul 24, 2015
	Recruiting star ratings: Scout:   Rivals:   247Sports:    ESPN:
Cornell Powell WR	Greenville, North Carolina	J.H. Rose H.S.	6 ft 2 in (1.88 m)	200 lb (91 kg)	4.45	Feb 4, 2015
	Recruiting star ratings: Scout:   Rivals:   247Sports:    ESPN:
Nyles Pinckney DT	Seabrook, South Carolina	Whale Branch H.S.	6 ft 1 in (1.85 m)	295 lb (134 kg)	—	Aug 21, 2015
	Recruiting star ratings: Scout:   Rivals:   247Sports:    ESPN:
John Simpson OG	North Charleston, South Carolina	Fort Dorchester H.S.	6 ft 4 in (1.93 m)	290 lb (130 kg)	—	Feb 3, 2016
	Recruiting star ratings: Scout:   Rivals:   247Sports:    ESPN:
Diondre Overton WR	Greensboro, North Carolina	Page H.S.	6 ft 5 in (1.96 m)	200 lb (91 kg)	—	Jan 3, 2016
	Recruiting star ratings: Scout:   Rivals:   247Sports:    ESPN:
Tavares Chase WR	Plant City, Florida	Plant City H.S.	6 ft 2 in (1.88 m)	167 lb (76 kg)	—	Jan 31, 2015
	Recruiting star ratings: Scout:   Rivals:   247Sports:    ESPN:
Zerrick Cooper QB	Jonesboro, Georgia	Jonesboro H.S.	6 ft 4 in (1.93 m)	206 lb (93 kg)	—	Oct 11, 2015
	Recruiting star ratings: Scout:   Rivals:   247Sports:    ESPN:
Sean Pollard OL	Southern Pines, North Carolina	Pinecrest H.S.	6 ft 6 in (1.98 m)	305 lb (138 kg)	—	Dec 12, 2014
	Recruiting star ratings: Scout:   Rivals:   247Sports:    ESPN:
Isaiah Simmons DB	Olathe, Kansas	Olathe North H.S.	6 ft 3 in (1.91 m)	205 lb (93 kg)	—	Feb 3, 2016
	Recruiting star ratings: Scout:   Rivals:   247Sports:    ESPN:
Tremayne Anchrum OG	Powder Springs, Georgia	McEachern H.S.	6 ft 3 in (1.91 m)	268 lb (122 kg)	—	Nov 19, 2015
	Recruiting star ratings: Scout:   Rivals:   247Sports:    ESPN:
J.C. Chalk TE	Argyle, Texas	Argyle H.S.	6 ft 4 in (1.93 m)	240 lb (110 kg)	—	Nov 6, 2014
	Recruiting star ratings: Scout:   Rivals:   247Sports:    ESPN:
James Skalski LB	Newnan, Georgia	Northgate H.S.	6 ft 1 in (1.85 m)	225 lb (102 kg)	—	Feb 4, 2015
	Recruiting star ratings: Scout:   Rivals:   247Sports:    ESPN:
Chandler Reeves OT	McDonough, Georgia	Eagles Landing Christian H.S.	6 ft 6 in (1.98 m)	255 lb (116 kg)	—	Jun 19, 2015
	Recruiting star ratings: Scout:   Rivals:   247Sports:    ESPN:
K'Von Wallace DB	Highland Springs, Virginia	Highland Springs H.S.	6 ft 0 in (1.83 m)	172 lb (78 kg)	—	Feb 3, 2016
	Recruiting star ratings: Scout:   Rivals:   247Sports:    ESPN:
Overall recruiting rankings: Scout: 14   Rivals: 5  247Sports: 10  ESPN: 8
‡ Refers to 40 yard dash Note: In many cases, Scout, Rivals, 247Sports, and ESPN may conflict in their listings of height, weight and 40 time. In these cases, the average was taken. ESPN grades are on a 100-point scale. Sources: "Clemson Football Commitments". Rivals.com. Retrieved February 6, 2016. "2016 Team Ranking". Rivals.com. Retrieved February 6, 2016.

Auburn

Clemson began the year ranked second in the AP Poll and traveled to unranked historic rival Auburn to begin the season. Clemson survived an early scare and won the game 19–13.^[8]

Clemson received the opening kickoff and got as far as the Auburn 32 yard line but failed to convert on 4th and 5. Both teams struggled to move the ball for the first quarter. Auburn opened the scoring early in the second quarter with a 53-yard field goal by Daniel Carlson. Clemson responded with a 13-play, 84-yard drive that ended with a one-yard touchdown run by Wayne Gallman. Clemson got the ball back with 3:00 left in the half and extended their lead with a 30-yard field goal by Greg Huegel. The score was 10–3 at halftime.

After forcing an Auburn three-and-out to open the second half, Clemson again kicked a field goal, this one from 40-yards out to bring the score to 13–3 Clemson. After the teams traded interceptions and another set of unsuccessful downs, Auburn kicked a 32-yard field goal early in the fourth quarter. Clemson responded with a 75-yard drive that ended with a 16-yard touchdown pass from Deshaun Watson to Hunter Renfrow, but Greg Heugel's extra point attempt missed off the upright, after which the score was 19–6 with 9:59 left in the game. Auburn's Kerryon Johnson scored a nine-yard touchdown run with 3:22 left to pull within 6 points. Clemson drove to the Auburn 17 yard line, but elected to go for it on 4th and 4 with 40 seconds left in the game rather than kick a field goal to potentially go up by 9 points. The fourth down attempt failed, and Auburn had a chance to win the game with their final drive. Head coach Dabo Swinney explained the decision: "We just didn't want to take a shot at the field goal right there. We felt like as good as we had played defensively, with them having no timeouts, it was going to be very difficult for them to go score." Auburn advanced to the Clemson 40 yard line, but a series of Hail Mary passes came up incomplete, and the game was over. Deshaun Watson finished with 248 yards in the game, and wide receiver Mike Williams finished with 174 yards.^[8]

Troy

Clemson returned home for their home opener against Troy of the Sun Belt Conference. The Tigers had another surprisingly close game against an unranked opponent, pulling away late for a 30–24 win.^[11]

After the two teams each went three-and-out on their first two drives, Troy opened the scoring with a 39-yard field goal. Clemson tied the game with a 26-yard field goal on the following drive. Early in the second quarter, Clemson scored the game's first touchdown with a Deshaun Watson 35-yard pass to Hunter Renfrow. Troy tied the game on the next drive with a 66-yard touchdown run by Jabir Frye. Later in the quarter, Clemson kicked a 32-yard field goal to take a 13–10 lead. On Troy's next drive, the Trojans were forced to punt, and Clemson's Ray-Ray McCloud appeared to return the punt 75 yards for a touchdown. The play was reviewed, however, and it was revealed that McCloud celebrated too early and released the ball for a fumble just before the goal line. Troy was awarded the ball at the 20 yard line and advanced into Clemson territory, but missed a 48-yard field goal attempt just before the half.

The third quarter featured no points scored, with seven punts by the two teams and a Deshaun Watson interception. Early in the fourth quarter, Clemson capped off an 81-yard drive with a one-yard touchdown pass from Watson to defensive end Christian Wilkins. On the next drive, Clemson scored another touchdown via a 23-yard pass from Watson to Deon Cain to push the score to 27–10 Clemson. With 4:59 left in the game, Troy scored another touchdown via a two-yard pass from Brandon Silvers to Deondre Douglas. Clemson kicked a field goal on the following drive. With 44 seconds left, Troy pulled within 6 points by scoring another touchdown with another Silvers to Douglas pass. Troy's onside kick attempt failed, and Clemson drained the clock to win the game. Deshaun Watson finished with 292 yards, three touchdowns, and two interceptions in the game.^[11]

South Carolina State

For their third game of the year, Clemson hosted in-state FCS foe South Carolina State. Clemson won in a predictable blow-out, 59–0. The two teams' head coaches agreed at halftime to shorten the quarters in the second half to 12 minutes each from the usual 15 minutes.^[14]

Clemson scored on each of their first six drives in the first half, and had a special teams score as well. On the opening drive, Deshaun Watson completed a seven-yard touchdown pass to Ray-Ray McCloud. On the second drive, running back Wayne Gallman ran for a three-yard score. On the ensuing kickoff, the SC State return man fielded the ball in the endzone, and flipped the ball toward the referee without ever signalling for a fair catch or kneeling with the ball for a touchback. Clemson jumped on the ball in the endzone for the touchdown. After a 45-yard touchdown pass from backup quarterback Nick Schuessler to Diondre Overton, a Bulldog interception, and a Tiger field goal, Clemson was up 31–0 at the end of the first quarter. Deshaun Watson added two touchdown passes in the second quarter, and the score was 45–0 at halftime. In shortened quarters in the second half, Clemson added two more touchdowns via a run by Tavien Feaster and a pass from Kelly Bryant to Trevion Thompson. With the 59–0 win, Clemson improved to 31–0 all-time against FCS opponents.^[15]

At Georgia Tech

Clemson next traveled to Atlanta for a Thursday night game against Georgia Tech in their conference opener. Clemson rolled early and came away with a convincing 26–7 win.^[17]

Clemson received the opening kickoff and scored in their opening drive via a four-yard touchdown pass from Deshaun Watson to Mike Williams. Clemson's next drive ended in a missed 27-yard field goal by Greg Heugel, but the Tigers scored on the following drive with a one-yard run by Wayne Gallman. Late in the second quarter, Watson threw an interception in Georgia Tech's endzone, but the Georgia Tech defender fumbled the ball and his teammate fell on it for a Clemson safety. The Tigers then marched down the field in the final minutes of the half and scored another touchdown, a nine-yard pass from Watson to Jordan Leggett, to bring the score to 23–0 at halftime. The second half was mostly uneventful, with the first points coming early in the fourth quarter via a Georgia Tech two-yard touchdown run to break up shutout. Clemson added a field goal to bring the score to 26–7 at the end. Deshaun Watson crossed the 300 yard mark for the first time on the year, finishing with 304 yards and two touchdowns.^[17]

Louisville

Clemson returned home for a highly anticipated match-up against Louisville. The Cardinals were led by eventual Heisman Trophy-winning quarterback Lamar Jackson and were ranked third in the country, while Clemson had slid to fifth in the polls. ESPN College Gameday came to campus during the week of the game. The game lived up to the hype, as Clemson won a tight contest, 42–36.^[20]

The game started off slowly, with each team punting on their first three possessions. Louisville struck first in the second quarter with a one-yard touchdown run by Jeremy Smith. Clemson tied the game with a 33-yard pass from Deshaun Watson to Deon Cain. After a Louisville fumble at their own 39 yard line, Wayne Gallman extended the Clemson lead with a 24-yard touchdown run. With 3:27 left in the half, Watson completed another touchdown pass to Cain. Louisville kicked a field goal with 36 seconds left in the half, but Watson led a rapid touchdown drive before the half, completing a five-yard pass to Artavis Scott to make the score 28–10.

The start of the second half went much better for the Cardinals, as they scored 26 unanswered points to take the lead. Clemson's first drive ended with a Deshaun Watson interception at their own 36 yard line, after which Lamar Jackson completed an eight-yard touchdown pass to James Quick. Louisville added a field goal, and then, after a fumble by Clemson's Jordan Leggett, scored another touchdown, this time on a one-yard Lamar Jackson run. Louisville added another field goal, followed by another Watson interception. Lamar Jackson led the Cardinals down the field and ran in for an 11-yard touchdown to take a 36–28 lead with 7:52 remaining in the game. Clemson's Artavis Scott returned the ensuing kickoff 77 yards to the Louisville 23 yard line, and Deshaun Watson connected with Mike Williams for a 20-yard touchdown two plays later. A Clemson two-point conversion attempt ended in an interception, and so Clemson trailed by two points. The Tiger defense forced a Louisville three-and-out, and Watson led Clemson down the field again and scored a 31-yard touchdown pass to Jordan Leggett to take the lead with 3:14 remaining. Watson and Leggett connected again for the two-point conversion and a six-point lead. Lamar Jackson led the Cardinals down the field and got as far as the Clemson 9 yard line in the final minute of the game, but failed to convert on 4th and 12 and turned the ball over on downs. Clemson wound down the clock to win the game.

Deshaun Watson threw for 306 passing yards, five touchdowns, and three interceptions. He added 91 rushing yards on the ground. Louisville's Lamar Jackson had 295 passing yards and 162 rushing yards.^[20]

At Boston College

Clemson next traveled to Chestnut Hill, Massachusetts to play Boston College. Clemson won convincingly to win the O'Rourke–McFadden Trophy, 56–10.^[23]

Boston College was forced to punt after their first drive, but Clemson's Ray-Ray McCloud fumbled the punt at Clemson's own nine yard line. BC settled for a 21-yard field goal four plays later. On the next drive, Wayne Gallman broke off a 59-yard touchdown run to take the lead for the Tigers. Deshaun Watson added two more first quarter touchdowns for Clemson via a nine-yard pass to Mike Williams and a 56-yard pass to Jordan Leggett. Neither team scored in the second quarter, and the score was 21–3 at halftime. Clemson scored touchdowns on each of their first three drives of the second half to put the game away. The first was a 29-yard pass from Watson to Deon Cain, followed by another Watson-to-Cain connection for 16 yards. Boston College's sole touchdown came in the third quarter via a one-yard pass from Bobby Wolford to Patrick Towles. Clemson scored two rushing touchdowns in the fourth quarter, from Tyshon Dye and Tavien Feaster. Clemson scored one last time in the final two minutes with a 42-yard interception return for a touchdown by Mark Fields.^[23]

NC State

Clemson next returned home to face ACC opponent NC State. Clemson survived another close call and won the game in overtime, 24–17.^[26]

Clemson got on the board first with a late first quarter field goal by Greg Huegel. NC State answered with a field goal of their own with 2:03 left in the first half. Deshaun Watson led a successful two-minute drill and scored the game's first touchdown via a 13-yard pass to Mike Williams just before the half to secure a 10–3 lead. Clemson received the second half kickoff, but two plays later, Watson threw his first career pick six, returned 28 yards for a touchdown by NC State's Mike Stevens. Clemson fumbled the ball on their next two possessions, but benefited from a missed field goal and took a 17–10 lead with a Watson touchdown run late in the third quarter. NC State responded with a 14-play touchdown drive that ended in a two-yard run by Matthew Dayes to tie the game. Clemson was forced to punt with 6:39 remaining, and NC State was able to wind down the clock and drive the ball down to the Clemson 16 yard line. NC State kicker Kyle Bambard lined up for the potential game-winning field goal from just 33 yards out, but missed it wide right as time expired in regulation. In overtime, Clemson was able to score a touchdown with a 10-yard pass from Deshaun Watson to Artavis Scott. NC State's possession ended on the first play when Ryan Finley threw an interception caught by Marcus Edmond in the endzone.

At Florida State

After the win against NC State, Clemson traveled to Tallahassee, Florida to face No. 12 Florida State. Clemson pulled off yet another close win, pulling ahead late to win 37–34. It was their first win on the road against FSU in 10 years.^[28]

Clemson scored on the game's opening drive via a one-yard run by Wayne Gallman, and scored again on their following drive with a four-yard pass from Deshaun Watson to Hunter Renfrow to take an early 14–0. After a Watson interception at the FSU 40 yard line, the Seminoles scored with a four-yard run by Dalvin Cook. Clemson added a field goal with 1:49 left in the half, but Florida State was able to march down the field and score a five-yard touchdown pass from Deandre Francois to Nyqwan Murray before the half, making the score 17–14 Clemson at halftime.

Clemson kicked a field goal on their first possession of the second half, but in their next possession, Watson threw another interception at their own 43 yard line. On the next play, Dalvin Cook ran the ball to the house for a touchdown and the lead. Later in the quarter, Cook extended the Florida State lead to eight with a 70-yard touchdown run. Clemson responded with a 75-yard drive that ended with a two-yard Wayne Gallman touchdown run to pull within two. The Tigers took a one point lead with a 46-yard field goal with 5:25 remaining. Dalvin Cook scored his career-high-setting fourth touchdown of the day with an eight-yard run with 3:23 remaining to claim the lead again for Florida State. Deshaun Watson responded with a 34-yard touchdown pass to Jordan Leggett, and the Tigers converted the two-point attempt to secure a 37–34 lead with 2:06 remaining. Florida State got as far as the Clemson 34 yard line, but penalties and a sack by Christian Wilkins pushed them far out of field goal range to end the game. Deshaun Watson finished with 430 total yards of offense in the game.^[28]

Syracuse

After beating Florida State, Clemson returned home to face Syracuse. Clemson won in a blowout, 54–0.^[31]

Deshaun Watson scored the game's first three touchdowns before leaving the game with a bruised shoulder. Head coach Dabo Swinney said the injury was not likely to affect the next week's game against Pittsburgh. His first touchdown came via a one-yard run, followed by a 65-yard pass to Deon Cain and then a 14-yard pass to Mike Williams. Nick Schuessler and Kelly Bryant traded snaps at quarterback for the remainder of the game. Schuessler had two touchdowns through the air, while Wayne Gallman added another on the ground. Tanner Muse added a 64-yard interception return in the fourth quarter for Clemson's last points of the day.^[31]

Pittsburgh

Clemson's next game was against Pittsburgh. The Panthers stunned the Tigers at home, winning by a score of 43–42. It was the first loss to an unranked opponent in 46 games for Clemson, who at the time of the game was ranked second in the CFP rankings and third in the AP Poll.^[34]

Pittsburgh received the opening kickoff and scored on their first drive with a pass from Nathan Peterman to George Aston from 15 yards out. Wayne Gallman tied the game for Clemson with a one-yard touchdown run two drives later. Pittsburgh responded with a 46-yard touchdown pass from Peterman to James Conner, which was followed by another one-yard Gallman run to tie the game at 14 apiece at the end of the first quarter. Clemson took the lead with a 15-yard touchdown pass from Deshaun Watson to Mike Williams, but Pittsburgh scored once again with a 55-yard touchdown pass from Peterman to Scott Orndoff. Chris Blewitt's extra point missed, so Pittsburgh trailed 21–20. The Panthers took the lead with 2:23 left in the first half with another Peterman touchdown pass, this time from one yard out complete to George Aston. Clemson took back their one point lead with a 13-yard touchdown pass from Watson to Artavis Scott with 1:09 remaining in the half. Pittsburgh drove to the Clemson 35 yard line in the final minute, but Blewitt's 53-yard field goal attempt was blocked by Dexter Lawrence.

In the second half, Clemson extended their lead to eight with a 27-yard touchdown pass from Deshaun Watson to Deon Cain. Pittsburgh once again cut the lead to one with a Nathan Peterman touchdown pass, his fifth of the game, a career high. Near the end of the third quarter, Clemson running back Wayne Gallman scored another touchdown from one yard out. In the fourth quarter, with Clemson driving again, Watson threw an interception in the Pittsburgh endzone, which was returned 70 yards to the Clemson 30 by Saleem Brightwell. Three plays later, Pittsburgh pulled within two points with 5:17 remaining with a 20-yard run by James Conner (their two point conversion attempt failed). Watson and the Clemson offense drove to the Pittsburgh 35 yard line, but Wayne Gallman was stuffed on 4th and 1 to turn the ball over with 58 seconds to go. Peterman led the Pittsburgh offense down the field, and Chris Blewitt kicked the go-ahead 48-yard field goal with six seconds remaining. Deshaun Watson finished with a career-high 580 passing yards in the game.^[34]

At Wake Forest

Following the loss to Pittsburgh, Clemson traveled to Winston-Salem, North Carolina to face Wake Forest with a chance to clinch the ACC Atlantic Division title. Clemson did just that with a 35–13 victory.^[37]

Clemson scored on each of their first four possessions to take a commanding 28–0 lead. The first score came with a 42-yard touchdown run by Wayne Gallman. Deshaun Watson then ran one in himself from three yards, followed by a 15-yard touchdown pass to Mike Williams, and another rushing touchdown early in the second quarter. On Wake Forest's next possession, they were forced to punt, but Clemson's Ray-Ray McCloud fumbled the punt on Clemson's 27 yard line. Wake Forest settled for a 42-yard field goal four plays later. The Demon Deacons were able to drive down the field on their next possession and score a one-yard touchdown run to make the score 28–10 at halftime. Wake Forest was first to score in the second half with a 23-yard field goal. Wayne Gallman punched in a one-yard touchdown run early in the fourth quarter to secure the 35–13 lead for Clemson that held until the end of the game.^[37]

South Carolina

Clemson held their regular season finale at home against in-state rival South Carolina. Clemson won in a blowout, 56–7, the school's third straight win against South Carolina and their largest margin of victory in the series since winning 51–0 in 1900.^[40]

Clemson's first drive of the game ended with a blocked 39-yard field goal attempt, but on the next play they intercepted a pass from South Carolina's Jake Bentley, and scored a touchdown three plays later via a 34-yard touchdown pass from Deshaun Watson to Mike Williams. Watson and Williams connected again for a 19-yard touchdown on the next drive, and on the drive after that Watson threw an 11-yard touchdown pass to Jordan Leggett to take a 21–0 lead in the first quarter. Clemson added two more touchdowns in the final 3:06 of the first half with an eight-yard run by Wayne Gallman and another Watson-Williams pass from 16 yards out. The score was 35–0 at halftime. In the second half, Clemson scored on their first possession with a pass from Watson to C. J. Fuller. South Carolina broke up the shutout on the next drive with a 33-yard pass from wide receiver Deebo Samuel to Bryan Edwards. Clemson responded with yet another touchdown, with Deshaun Watson throwing his fifth touchdown pass of the game (a career high) to Artavis Scott. Kelly Bryant added a rushing touchdown before the end of the game to bring the final score to 56–7.^[40]

Vs. Virginia Tech—ACC Championship Game

Clemson and Louisville both finished with ACC records of 7–1, but since Clemson won the head-to-head match-up, the Tigers won the tiebreaker to represent the Atlantic Division in the 2016 ACC Championship Game in Orlando, Florida. Clemson defeated Coastal Division champion Virginia Tech, 42–35, to win the Atlantic Coast Conference for the second straight year.^[42]

Clemson received the opening kickoff and scored on their opening drive via a three-yard touchdown run by Deshaun Watson. They expanded their lead to 14 on the next drive with a 21-yard pass from Watson to Jordan Leggett. Near the end of the first quarter, Virginia Tech got on the board with a one-yard touchdown run by Travon McMillian. Clemson responded with another touchdown pass from Watson to Leggett from 10 yards out. Virginia Tech scored another touchdown with 4:09 left in the half with an 11-yard touchdown run by Jerod Evans to make the score 21–14 Clemson. This proved to be the final score of the half.

After two Virginia Tech punts and a Deshaun Watson interception to start the second half, Clemson scored on an 89-yard drive that ended with a Wayne Gallman eight-yard run. Later in the quarter, Watson, scored on a two-yard run to make the score 35–14. Virginia Tech scored 14 unanswered points with touchdown runs by Travon McMillian and Jerod Evans to pull within a touchdown of Clemson. Deshaun Watson again extended the lead with a 15-yard touchdown pass to Hunter Renfrow. Virginia Tech scored again on their next possession with a 26-yard pass from Jerod Evans to Cam Phillips with 5:43 remaining. Down by seven points, Virginia Tech drove to the Clemson 23 yard line in the final two minutes, but a Jerod Evans pass was intercepted by Cordrea Tankersley. Clemson wound down the clock to end the game.^[42]

Vs. Ohio State—Fiesta Bowl (CFP semifinal)

In the final College Football Playoff rankings of the year, Clemson (12–1) was ranked second, earning them their second consecutive playoff bid and a spot in the semifinal game to be played at the Fiesta Bowl. Their opponent was Ohio State (11–1), who was somewhat controversially ranked third after failing to reach the Big Ten Championship Game by finishing in second in the East Division to Penn State. Ohio State was considered a three-point favorite in the game by Las Vegas sportsbooks.^[43] Clemson shutout the Buckeyes by a score of 31–0 in the Fiesta Bowl to advance to the CFP Championship Game. It was the second shutout in the history of the CFP.^[44]

Clemson's first drive ended abruptly with a Deshaun Watson interception on their second play at their own 33 yard line. Ohio State failed to capitalize, missing a 47-yard field goal four plays later. Clemson's next drive ended with a 45-yard field goal by Greg Heugel. Ohio State missed another 47-yard field goal on their next possession. Clemson scored their first touchdown on the following drive with a one-yard run by Deshaun Watson. They extended their lead with 2:21 left in the first half with a 30-yard pass from Watson to C. J. Fuller. The score was 17–0 at halftime. The third quarter featured little offensive success for either team until Deshaun Watson scored a seven-yard touchdown run late in the quarter. Ohio State's J. T. Barrett threw two interceptions on their following two drives, and Clemson scored again with a seven-yard run by Wayne Gallman to make the score 31–0 with 8:51 left to play. This proved to be the final score of the game. Deshaun Watson was named offensive MVP, and defensive lineman Clelin Ferrell was named defensive MVP.^[44][45][46]

Vs. Alabama—2017 CFP National Championship

By winning the Fiesta Bowl, Clemson advanced to the 2017 College Football Playoff National Championship to face the winner of the Peach Bowl, top-seeded Alabama (14–0). Clemson had lost to Alabama in the previous year's national championship, and this marked the first time since the inception of college football national title games in the 1990s of a rematch played between two schools. Alabama was considered a 6.5-point favorite to repeat as champions.^[48] Clemson won in dramatic fashion, 35–31, to secure their first national title since 1981.^[49]

Alabama was the first to score, with a 25-yard touchdown by Bo Scarbrough. They extended their lead to 14 with a 37-yard touchdown run early in the second quarter, again by Scarbrough. Three drives later, Clemson got on the board with an eight-yard touchdown run by Deshaun Watson with 6:09 left in the half. Both teams failed to score for the rest of the half, and the score was 14–7 Alabama at halftime.

Clemson received the second half kickoff, but four plays into the drive Wayne Gallman fumbled the ball at their own 28 yard line, and it was returned by Alabama's Ryan Anderson to the 16 yard line. Alabama failed to move the ball and settled for a 27-yard field goal. The two teams traded punts on their next possessions, before Deshaun Watson connected with Hunter Renfrow for a 24-yard touchdown pass to pull within three points. The two teams again traded punts, before Alabama's Jalen Hurts threw a 68-yard touchdown pass to tight end O. J. Howard to make the score 24–14 at the end of the third quarter. Clemson responded with a 72-yard drive that ended with a four-yard touchdown pass from Watson to Mike Williams to again pull within three. The defenses forced punts on the following five drives. With 4:38 left in the game, Clemson's Wayne Gallman scored a one-yard touchdown to take the lead. Alabama's Jalen Hurts led the Crimson Tide down the field on the following drive, and with 2:07 remaining scored a 30-yard touchdown run.

Down by four, Deshaun Watson marched the Tigers offense down the field in the final two minutes. Watson connected with Jordan Leggett for a 17-yard pass to the Alabama nine yard line with 19 seconds remaining. On second down, Alabama was charged with pass interference, bringing the ball to the two yard line with 9 seconds remaining. On the next play, Deshaun Watson rolled to his right and found a wide-open Hunter Renfrow in the endzone for the go-ahead touchdown with just one second showing on the clock. Clemson was able to recover the ensuing onside kick and kneeled on the final play to win the game. Deshaun Watson was named offensive MVP, and linebacker Ben Boulware was named defensive MVP.^[49]

Undrafted signees

Along with the six draft picks, Clemson had one more player make the NFL as an undrafted free agent.

Individual awards

ACC Co-defensive Player of the Year - Ben Boulware^[50]

ACC Defensive Rookie of the Year - Dexter Lawrence^[51]

Paul "Bear" Bryant Award - Dabo Swinney

FBS Assistant of the Year - Dan Brooks ^[52]

Broyles Award - Brent Venables ^[53]

Johnny Unitas Award - Deshaun Watson

Davey O'Brien Award - Deshaun Watson

Bobby Bowden Award - Deshaun Watson

Manning Award - Deshaun Watson

Jack Lambert Trophy - Ben Boulware

Heisman Trophy finalist - Deshaun Watson (2nd)

All-Americans

• CB Cordrea Tankersley: 1st Team - USA Today; 2nd Team - Fox Sports; 3rd Team - AP, Athlon
• QB Deshaun Watson: 1st Team - Scout.com; 2nd Team - AP, AFCA, Athlon, Sporting News, Sports Illustrated, Walter Camp
• DT Carlos Watkins: 1st Team - CBS Sports; 2nd Team - AP, Athlon
• DE Christian Wilkins: 1st Team - AFCA, FWAA; 2nd Team - Fox Sports, Sporting News, USA Today, Walter Camp; 3rd Team - AP, Athlon
• LB Ben Boulware: 2nd Team - AFCA, FWAA, USA Today, Walter Camp; 3rd Team - AP, Athlon
• TE Jordan Leggett: 2nd Team - CBS Sports; 3rd Team - Athlon
• WR Mike Williams: 2nd Team - Walter Camp; 3rd Team - Athlon
• DT Dexter Lawrence: Freshman - FWAA, ESPN, Scout.com, USA Today

All-ACC Teams

• 1st Team: LB Ben Boulware, OG Tyrone Crowder, C Jay Guillermo, OT Mitch Hyatt, S Jadar Johnson, TE Jordan Leggett, CB Cordrea Tankersley, WR Mike Williams
• 2nd Team: RB Wayne Gallman, PK Greg Huegel, DT Dexter Lawrence, QB Deshaun Watson, DE Christian Wilkins
• 3rd Team: WR Artavis Scott
• Honorable Mention: LB Kendall Joseph, SP Ray-Ray McCloud, S Van Smith