2018 San Luis Open Challenger Tour
Date27 March – 1 April
Edition25th
Draw32S / 16D
SurfaceClay
LocationSan Luis Potosí, Mexico
Champions
Singles
El Salvador Marcelo Arévalo
Doubles
El Salvador Marcelo Arévalo / Mexico Miguel Ángel Reyes-Varela

The 2018 San Luis Open Challenger Tour was a professional tennis tournament played on hard courts. It was the 25th edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in San Luis Potosí, Mexico between 27 March and 1 April 2018.

Singles main-draw entrants

Seeds

Country Player Rank1 Seed
 ITA Paolo Lorenzi 57 1
 AUT Gerald Melzer 113 2
 GER Yannick Hanfmann 124 3
 BRA Thomaz Bellucci 135 4
 DOM Víctor Estrella Burgos 152 5
 USA Evan King 188 6
 USA Mitchell Krueger 207 7
 SRB Peđa Krstin 208 8
  • 1 Rankings are as of 19 March 2018.

Other entrants

The following players received wildcards into the singles main draw:

The following players received entry from the qualifying draw:

Champions

Singles

Doubles

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