Teams

Group stage
CB Ademar León	USAM Nîmes Gard	SC Magdeburg	Grundfos Tatabanya KC
RK Eurofarm Pelister	Orlen Wisła Płock	Dinamo București	Chekhovskiye Medvedi
Kadetten Schaffhausen	HT Tatran Prešov	Alingsås HK	Besiktas Aygaz
Second qualifying round
RK Nexe	GOG Håndbold	BM Benidorm	Fenix Toulouse Handball
Montpellier HB	Füchse Berlin	Rhein-Neckar Löwen	Balatonfüredi KSE
Sporting CP
First qualifying round
Fivers	SKA Minsk	HRK Gorica	RK Dubrava
RK Spacva Vinkovci	Bjerringbro-Silkeborg	Skjern Håndbold	TTH Holstebro
Bidasoa Irun	PAUC Handball	MT Melsungen	B. Braun Gyöngyös
Valur	Handball Esch	HC Butel Skopje	RK Metalurg Skopje
Haslum HK	ØIF Arendal	KS Azoty-Puławy	CF Os Belenenses
SL Benfica	HC Dobrogea Sud Constanta	AHC Potaissa Turda	HC CSKA
HC Victor	RK Trimo Trebnje	HC Kriens-Luzern	Pfadi Winterthur
HK Malmö	IFK Kristianstad

First qualifying round

Matches

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
AHC Potaissa Turda	56–53	HRK Gorica	24–26	32–27
HC Dobrogea Sud Constanta	54–45	HC Victor	26–18	28–27
SKA Minsk	50–56	HC CSKA	25–25	25–31
B. Braun Gyöngyös	58–46	HC Butel Skopje	34–21	24–25
RK Metalurg Skopje	60–57	RK Spacva Vinkovci	35–28	25–29
TTH Holstebro	Cancelled[note 1]	Valur	Cancelled	Cancelled
IFK Kristianstad	Cancelled[note 2]	ØIF Arendal	Cancelled	Cancelled
Bjerringbro-Silkeborg	57–51	MT Melsungen	31–27	26–24
Skjern Håndbold	53–51	HK Malmö	27–26	26–25
KS Azoty-Puławy	Cancelled[note 2]	Haslum HK	Cancelled	Cancelled
SL Benfica	62–64	Fivers	28–26	34–38
Pfadi Winterthur	33–30	Handball Esch	33–30	Cancelled
PAUC Handball	25–30[note 3]	Bidasoa Irun	Cancelled	25–30
CF Os Belenenses	49–56	RK Trimo Trebnje	23–28	26–28
HC Kriens-Luzern	57–46	RK Dubrava	29–27	28–19

Second qualifying round

Matches

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
HC Dobrogea Sud Constanta	48–49	Sporting CP	27–27	21–22
KS Azoty-Puławy	46–49	IFK Kristianstad	24–25	22–24
BM Benidorm	Cancelled[note 4]	Fivers	34–31	Cancelled
TTH Holstebro	49–54	Rhein-Neckar Löwen	22–28	27–26
Bjerringbro-Silkeborg	50–55	HC CSKA	26–23	24–32
AHC Potaissa Turda	62–66	Fenix Toulouse Handball	35–35	27–31
Bidasoa Irun	54–56	RK Nexe	30–27	24–29
RK Metalurg Skopje	47–46	HC Kriens-Luzern	26–24	21–22
GOG Håndbold	64–59	Pfadi Winterthur	33–24	31–35
Skjern Håndbold	60–63	Montpellier HB	31–30	29–33
B. Braun Gyöngyös	47–61	Füchse Berlin	23–25	24–36
RK Trimo Trebnje	23–22[note 5]	Balatonfüredi KSE	23–22	Cancelled

Seeding

The 24 teams were divided into six pots of four teams, with a team from each pot being drawn to each group. Teams from the same country could not be drawn into the same group.^[11]

Tiebreakers

Teams were ranked according to points (2 points for a win, 1 point for a draw, 0 points for a loss), and if tied on points, the following tiebreaking criteria were applied, in the order given, to determine the rankings:

1. Points in matches among tied teams;
2. Goal difference in matches among tied teams;
3. Away goals scored in matches among tied teams;
4. Goal difference in all group matches;
5. Goals scored in all group matches;
6. If more than two teams were tied, and after applying all head-to-head criteria above, a subset of teams were still tied, all head-to-head criteria above were reapplied exclusively to this subset of teams;
7. Drawing lots.

Group A

Pos	Team	Pld	W	D	L	GF	GA	GD	Pts	Qualification
1	Orlen Wisła Płock	10	8	0	2	297	242	+55	16	Knockout stage
2	CB Ademar León	10	5	4	1	307	296	+11	14
3	Chekhovskiye Medvedi	10	7	0	3	301	264	+37	14
4	Fivers	10	2	2	6	301	311	−10	6
5	Fenix Toulouse Handball	10	2	2	6	227	250	−23	6
6	RK Metalurg Skopje	10	1	2	7	259	329	−70	4

Group B

Pos	Team	Pld	W	D	L	GF	GA	GD	Pts	Qualification
1	Füchse Berlin	10	6	2	2	247	223	+24	14	Knockout stage
2	USAM Nîmes Gard	10	5	2	3	279	263	+16	12
3	IFK Kristianstad	10	5	1	4	273	276	−3	11
4	Sporting CP	10	5	0	5	244	241	+3	10
5	Dinamo București	10	3	1	6	279	298	−19	7
6	HT Tatran Prešov	10	3	0	7	233	254	−21	6

Group C

Pos	Team	Pld	W	D	L	GF	GA	GD	Pts	Qualification
1	SC Magdeburg	10	9	0	1	321	230	+91	18	Knockout stage
2	HC CSKA	10	7	0	3	263	219	+44	14
3	Montpellier HB	10	6	0	4	231	197	+34	12
4	RK Nexe	10	5	0	5	269	284	−15	10
5	Alingsås HK	10	3	0	7	262	304	−42	6
6	Besiktas Aygaz	10	0	0	10	238	350	−112	0

Group D

Pos	Team	Pld	W	D	L	GF	GA	GD	Pts	Qualification
1	Rhein-Neckar Löwen	10	8	1	1	296	256	+40	17	Knockout stage
2	Kadetten Schaffhausen	10	6	2	2	261	251	+10	14
3	GOG Håndbold	10	6	0	4	306	305	+1	12
4	RK Eurofarm Pelister	10	5	1	4	244	237	+7	11
5	RK Trimo Trebnje	10	3	0	7	250	273	−23	6
6	Grundfos Tatabanya KC	10	0	0	10	263	298	−35	0

Last 16

The last 16 first legs were scheduled for 23 March 2021, while the second legs followed on 30 March 2021.^[13]

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
GOG Håndbold	68–61	HC CSKA	33–31	35–30
Sporting CP	53–54	Orlen Wisła Płock	25–29	28–25
Montpellier HB	59–52	Kadetten Schaffhausen	27–27	32–25
Fivers	27–45	Füchse Berlin	27–35	0–10
IFK Kristianstad	68–58	CB Ademar León	34–27	34–31
RK Eurofarm Pelister	48–67	SC Magdeburg	24–32	24–35
Chekhovskiye Medvedi	54–49	USAM Nîmes Gard	30–25	24–24
RK Nexe	52–54	Rhein-Neckar Löwen	25–27	27–27

Quarterfinals

The quarter-finals first legs were scheduled for 13 April 2021, while the second legs followed on 20 April 2021.^[14]

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
GOG Håndbold	56–58	Orlen Wisła Płock	30–27	26–31
Montpellier HB	55–60	Füchse Berlin	32–29	23–31
IFK Kristianstad	59–73	SC Magdeburg	28–34	31–39
Chekhovskiye Medvedi	60–69	Rhein-Neckar Löwen	33–32	27–37

Final four

The EHF Finals Men 2021 was played on 22 and 23 May 2021 in Mannheim, Germany and comprised one leg semifinals, final and third-place match. The pairings for the semifinals were decided by drawing of lots.^[15]

Bracket

	Semifinals				Final
	22 May
	SC Magdeburg	30
					23 May
	Orlen Wisła Płock	29
					SC Magdeburg	28
	22 May
					Füchse Berlin	25
	Rhein-Neckar Löwen	32
	Füchse Berlin	35
					Third place
					23 May
					Orlen Wisła Płock	27
					Rhein-Neckar Löwen	32

Semifinals

22 May 2021 18:00	SC Magdeburg	30–29	Orlen Wisła Płock	SAP Arena, Mannheim Referees: Santos, Fonseca (POR)
	Damgaard, Magnússon 6	(13–15)	Krajewski, Szita 7
	4×	Report	2× 7×

---

22 May 2021 20:45	Rhein-Neckar Löwen	32–35	Füchse Berlin	SAP Arena, Mannheim Referees: Brkic, Jusufhodzic (AUT)
	Tollbring 7	(16–19)	Andersson 11
	2× 6× 1×	Report	2× 5×

Third-place game

23 May 2021 18:00	Orlen Wisła Płock	27–32	Rhein-Neckar Löwen	SAP Arena, Mannheim Referees: Bíró, Kiss (HUN)
	Krajewski, Szita 6	(12–15)	Tollbring 11
	2× 3×	Report	1× 3×

Final

23 May 2021 20:30	SC Magdeburg	28–25	Füchse Berlin	SAP Arena, Mannheim Referees: Nikolić, Stojković (SRB)
	Hornke, Magnússon 7	(15–8)	Lindberg 8
	1× 4×	Report	2× 3×