Singles
2021 Challenger de Santiago II
Champion	Juan Pablo Varillas
Runner-up	Sebastián Báez
Score	6–4, 7–5

Sebastián Báez was the defending champion^[1] but lost in the final to Juan Pablo Varillas.

Varillas won the title after defeating Báez 6–4, 7–5 in the final.

Seeds

Draw

Finals

	Semifinals							Final
	5	Sebastián Báez	6	6
		Nicolás Jarry	4	4
								5	Sebastián Báez	4	5
								3	Juan Pablo Varillas	6	7
	3	Juan Pablo Varillas	6	68	6
	2	Francisco Cerúndolo	3	710	3

Top half

	First round							Second round							Quarterfinals							Semifinals
	1	JM Cerúndolo	0	1
		N Kicker	6	6					N Kicker	4	4
		R Cid Subervi	4	77	5				F Mena	6	6
		F Mena	6	62	7											F Mena	3	1
	WC	D Fernández Flores	3	6	5										5	S Báez	6	6
	Alt	N Chappell	6	3	7			Alt	N Chappell	7	4	1
		D Svrčina	2	5				5	S Báez	5	6	6
	5	S Báez	6	7																		5	S Báez	6	6
	4	H Dellien	4	6	6																		N Jarry	4	4
	Alt	L Catarina	6	3	3			4	H Dellien	6	4	6
	Q	N Álvarez	5	1					C Ugo Carabelli	2	6	2
		C Ugo Carabelli	7	6											4	H Dellien	64	4
		N Jarry	6	6												N Jarry	77	6
		JP Ficovich	4	4					N Jarry	64	7	6
	Q	F Díaz Acosta	6	5	6			Q	F Díaz Acosta	77	5	4
	6	MT Barrios Vera	3	7	1

Bottom half

	First round							Second round							Quarterfinals							Semifinals
	7	JI Londero	2	3
		TA Tirante	6	6					TA Tirante	4	2
	PR	G Melzer	6	6				PR	G Melzer	6	6
		G Andreozzi	2	4											PR	G Melzer	1	3
	WC	Víctor Núñez	0	2											3	JP Varillas	6	6
		J Lenz	6	6					J Lenz	2	4
	Alt	H Casanova	68	67				3	JP Varillas	6	6
	3	JP Varillas	710	79																		3	JP Varillas	6	68	6
	8	F Meligeni Alves	6	3	4																	2	F Cerúndolo	3	710	3
	WC	G Lama	4	6	6			WC	G Lama	6	3	7
	PR	G Oliveira	6	6				PR	G Oliveira	4	6	5
	Q	Oliver Crawford	4	2											WC	G Lama	66	4
		M Pucinelli de Almeida	6	1	3										2	F Cerúndolo	78	6
	Q	Alexis Gautier	4	6	6			Q	A Gautier	4	2
	LL	C Rodríguez	3	6	2			2	F Cerúndolo	6	6
	2	F Cerúndolo	6	3	6

References

External links

• Main draw
• Qualifying draw