Singles
2021 Chile Open
Champion	Cristian Garín
Runner-up	Facundo Bagnis
Score	6–4, 6–7(3–7), 7–5
Draw	28
Seeds	8

Cristian Garín defeated Facundo Bagnis in the final, 6–4, 6–7^(3–7), 7–5 to capture the men's singles tennis title at the 2021 Chile Open.

Thiago Seyboth Wild was the defending champion, but chose not to defend his title.

Seeds

The top four seeds received a bye into the second round.

Draw

Finals

	Semifinals							Final
	1	Cristian Garín	6	6
		Daniel Elahi Galán	4	3
								1	Cristian Garín	6	63	7
									Facundo Bagnis	4	77	5
		Facundo Bagnis	7	6
	8	Federico Delbonis	5	3

Top half

	First round							Second round							Quarterfinals							Semifinals
								1	C Garín	6	6
		J Kovalík	1	6	4			Q	A Tabilo	2	2
	Q	A Tabilo	6	0	6										1	C Garín	6	6
		J Sousa	4	1											Q	JP Varillas	4	4
	Q	JP Varillas	6	6				Q	JP Varillas	6	77
		G Mager	6	64	64			7	F Coria	4	62
	7	F Coria	4	77	77																	1	C Garín	6	6
																							DE Galán	4	3
								3	P Andújar	1	67
		DE Galán	77	3	7				DE Galán	6	79
		D Altmaier	62	6	5											DE Galán	710	6
	WC	G Lama	5	2												R Carballés Baena	68	3
	WC	JM Cerúndolo	7	6				WC	JM Cerúndolo	2	0
		R Carballés Baena	6	77					R Carballés Baena	6	6
	6	S Caruso	4	65

Bottom half

	First round							Second round							Quarterfinals							Semifinals
	5	F Tiafoe	79	67	79
	WC	N Jarry	67	79	67			5	F Tiafoe	63	62
		F Bagnis	64	6	6				F Bagnis	77	77
		M Cecchinato	77	2	3											F Bagnis	4	6	6
		P Sousa	6	6											4	L Đere	6	3	3
		L Mayer	2	4					P Sousa	7	5	3
								4	L Đere	5	7	6
																							F Bagnis	7	6
	8	F Delbonis	6	65	6																	8	F Delbonis	5	3
		J Munar	4	77	4			8	F Delbonis	6	6
	SE	F Cerúndolo	1	2					A Martin	0	3
		A Martin	6	6											8	F Delbonis	6	6
	Q	H Rune	6	6											Q	H Rune	3	3
	Q	S Báez	3	2				Q	H Rune	6	6
								2	B Paire	2	3

Qualifying

Qualifying draw

First qualifier

	First round							Second round							Qualifying competition
	1	Alejandro Tabilo	6	6
		Nicolás Álvarez	4	3
								1	Alejandro Tabilo	77	6
									Pedro Sakamoto	60	4
	Alt	Rafael Matos	3	1
		Pedro Sakamoto	6	6
															1	Alejandro Tabilo	77	6
															Alt	Agustín Velotti	61	1
	Alt	Agustín Velotti	6	6
	WC	Daniel Antonio Núñez	4	3
								Alt	Agustín Velotti	7	4	6
								8	Tomás Martín Etcheverry	5	6	3
		Marcelo Tomás Barrios Vera	4	6	4
	8	Tomás Martín Etcheverry	6	2	6

Second qualifier

	First round							Second round							Qualifying competition
	2	Juan Pablo Varillas	4	7	77
		Christian Lindell	6	5	63
								2	Juan Pablo Varillas	6	6
									Geoffrey Blancaneaux	2	2
		Camilo Ugo Carabelli	6	2	2
		Geoffrey Blancaneaux	3	6	6
															2	Juan Pablo Varillas	6	6
																Felipe Meligeni Alves	4	1
		Guilherme Clezar	4	2
		Felipe Meligeni Alves	6	6
									Felipe Meligeni Alves	3	77	77
								5	Mario Vilella Martínez	6	65	63
		Lukáš Klein	4	2
	5	Mario Vilella Martínez	6	6

Third qualifier

	First round							Second round							Qualifying competition
	3	Emilio Gómez	6	6
		Facundo Mena	2	3
								3	Emilio Gómez	3	6	1
								WC	Holger Rune	6	4	6
	WC	Holger Rune	77	2	6
		Gonçalo Oliveira	63	6	2
															WC	Holger Rune	4	6	6
																Renzo Olivo	6	3	4
		Carlos Gómez-Herrera	6	4	4
		Renzo Olivo	2	6	6
									Renzo Olivo	64	6	6
									Hernán Casanova	77	2	3
		Hernán Casanova	4	6	6
	7	Andrea Collarini	6	3	2

Fourth qualifier

	First round							Second round							Qualifying competition
	4	João Domingues	4	2
	WC	Nicolás Kicker	6	6
								WC	Nicolás Kicker	6	6
									Thomaz Bellucci	0	4
		Elliot Benchetrit	2	2
		Thomaz Bellucci	6	6
															WC	Nicolás Kicker	6	4	1
																Sebastián Báez	3	6	6
		Sebastián Báez	6	65	6
		Orlando Luz	2	77	2
									Sebastián Báez	78	2	6
								6	João Menezes	66	6	2
	WC	Michel Vernier	2	3
	6	João Menezes	6	6

References

• Main draw
• Qualifying draw