Singles
2021 Città di Como Challenger
Champion	Juan Manuel Cerúndolo
Runner-up	Gian Marco Moroni
Score	7–5, 7–6(9–7)

Facundo Mena was the defending champion^[1] but chose not to defend his title.

Juan Manuel Cerúndolo won the title after defeating Gian Marco Moroni 7–5, 7–6^(9–7) in the final.

Seeds

Draw

Finals

	Semifinals							Final
	1	Daniel Altmaier	4	0r
	4	Juan Manuel Cerúndolo	6	3
								4	Juan Manuel Cerúndolo	7	79
									Gian Marco Moroni	5	67
		Gian Marco Moroni	6	3	4
	Q	Andrea Vavassori	3	6	0r

Top half

	First round							Second round							Quarterfinals							Semifinals
	1	D Altmaier	6	6
		J Domingues	2	0				1	D Altmaier	6	7
		J Menezes	4						J Menezes	0	5
	Alt	E Furness	1r												1	D Altmaier	77	6
	WC	Federico Iannaccone	5	6	6											R Bonadio	63	3
	SE	C Ugo Carabelli	7	3	4			WC	F Iannaccone	2	1
		R Bonadio	3	6	6				R Bonadio	6	6
	Q	A Erler	6	3	3																	1	D Altmaier	4	0r
	4	JM Cerúndolo	6	77																		4	JM Cerúndolo	6	3
		T Lamasine	4	62				4	JM Cerúndolo	5
	Q	L Miedler	6	2	4			Alt	G Zeppieri	0r
	Alt	G Zeppieri	4	6	6										4	JM Cerúndolo	7	6
	PR	J Cagnina	1	3r											SE	N Serdarušić	5	2
	WC	F Cobolli	6	3				WC	F Cobolli	4	0
	SE	N Serdarušić	6	6				SE	N Serdarušić	6	6
	7	M-A Hüsler	4	3

Bottom half

	First round							Second round							Quarterfinals							Semifinals
	5	F Gaio	6	3	6
	Q	P Chrysochos	1	6	3			5	F Gaio	5	1
	LL	A Vatutin	0r						GM Moroni	7	6
		GM Moroni	3													GM Moroni	6	4	6
	PR	A Arnaboldi	77	6											PR	A Arnaboldi	3	6	2
		T Gabashvili	65	2				PR	A Arnaboldi	4	6	6
	WC	F Forti	7	2	1			3	A Martin	6	4	3
	3	A Martin	5	6	6																		GM Moroni	6	3	4
	6	S Nagal	4	64																		Q	A Vavassori	3	6	0r
		A Kuznetsov	6	77					A Kuznetsov	6	3	4
		J Draper	4	6	3			Q	A Vavassori	2	6	6
	Q	A Vavassori	6	2	6										Q	A Vavassori	6	6
		N Borges	3	1											2	J Kovalík	3	4
	LL	F Agamenone	6	6				LL	F Agamenone	2	61
	PR	J Lenz	5	2				2	J Kovalík	6	77
	2	J Kovalík	7	6

References

External links

• Main draw
• Qualifying draw