Seeds

Country	Player	Rank1	Seed
AUT	Dominic Thiem	50	1
SVK	Alex Molčan	65	2
ESP	Pablo Andújar	67	3
CZE	Jiří Veselý	77	4
ESP	Roberto Carballés Baena	79	5
ESP	Jaume Munar	89	6
ITA	Marco Cecchinato	93	7
ESP	Carlos Taberner	94	8

• ¹ Rankings are as of 21 March 2022.^[3]

Other entrants

The following players received wildcards into the singles main draw:

• Carlos Gimeno Valero
• Dominic Thiem
• Stan Wawrinka It was announced at the press conference that Stan Wawrinka, the former world number 3,^[4] would participate in ATP Challenger 125 in Puente Romano in Marbella. He achieved almost every possible milestone in professional tennis. Stan Wawrinka won three Grand Slam titles, 16 ATP titles and an Olympic gold in Beijing with Roger Federer in the men’s doubles category.

The following players received entry into the singles main draw as alternates:

• Pedro Cachin
• Andrey Kuznetsov

The following players received entry from the qualifying draw:

• Javier Barranco Cosano
• Raúl Brancaccio
• Carlos Gómez-Herrera
• Lukáš Klein
• Pol Martín Tiffon
• Alexander Shevchenko

The following player received entry as a lucky loser:

• Nicolás Álvarez Varona

Seeds

Country	Player	Rank1	Seed
MNE	Danka Kovinić	66	1
	Varvara Gracheva	71	2
EGY	Mayar Sherif	73	3
NED	Arantxa Rus	75	4
FRA	Clara Burel	82	5
HUN	Panna Udvardy	83	6
ITA	Martina Trevisan	88	7
SVK	Anna Karolína Schmiedlová	92	8

• ¹ Rankings are as of 21 March 2022.

Other entrants

The following players received wildcards into the singles main draw:

• Elina Avanesyan
• Irene Burillo Escorihuela
• Andrea Lázaro García
• Nastasja Schunk

The following players entered the main draw using a protected ranking:

• Elisabetta Cocciaretto
• Mandy Minella

Withdrawals

Before the tournament

• Lucia Bronzetti → replaced by Tamara Korpatsch
• Dalma Gálfi → replaced by Mandy Minella
• Kristína Kučová → replaced by Katarzyna Kawa
• Greet Minnen → replaced by Rebeka Masarova
• Jule Niemeier → replaced by Zhu Lin
• Diane Parry → replaced by Anna Blinkova
• Nadia Podoroska → replaced by Anna-Lena Friedsam
• Alison Van Uytvanck → replaced by Ekaterine Gorgodze
• Maryna Zanevska → replaced by Lesia Tsurenko
• Zheng Saisai → replaced by Aleksandra Krunić

Seeds

Country	Player	Country	Player	Rank1	Seed
SRB	Aleksandra Krunić		Alexandra Panova	123	1
ROU	Irina Bara	GEO	Ekaterine Gorgodze	127	2

• Rankings are as of March 21, 2022

Other entrants

The following pairs received wildcards into the doubles main draw:

• Rebeka Masarova / Panna Udvardy

Men's singles

• Jaume Munar def. Pedro Cachin 6–2, 6–2.

Women's singles

• Mayar Sherif def. Tamara Korpatsch 7–6^(7–1), 6–4

Men's doubles

• Roman Jebavý / Philipp Oswald def. Hugo Nys / Jan Zieliński 7–6^(8–6), 3–6, [10–3].

Women's doubles

• Irina Bara / Ekaterine Gorgodze def. Vivian Heisen / Katarzyna Kawa 6–4, 3–6, [10–6]