Game 1

Kyle Schwarber hit a towering second-deck home run in Game 1.

Game 1 was a low-scoring pitcher's duel between Philadelphia's Zack Wheeler and San Diego's Yu Darvish. In the top of the first, with Kyle Schwarber at third and two outs, Jake Cronenworth made a diving stop to get Bryce Harper out at first and rob the Phillies of a run. In the fourth, Harper homered off of Darvish for the first run of the series. In the bottom of the inning, Wheeler retired the heart of the Padres' order. In the top of the sixth, Schwarber added on to the Phillies' lead, hitting a towering second-deck home run. Philadelphia's Seranthony Dominguez retired the side in the bottom of the eighth. In the ninth, a potential game-ending double play was spoiled when Bryson Stott missed a throw by third baseman Alec Bohm after a Juan Soto grounder. However, after a Manny Machado flyout, José Alvarado struck out Josh Bell to end the inning and the game. Wheeler struck out eight batters in Game 1, earning the win.

Game 2

Juan Soto hit a big game-tying double in Game 2.

Philadelphia jumped on top early in Game 2, scoring four runs off of Blake Snell in the top of the second by way of a bloop single by Alec Bohm that scored Bryce Harper, a Matt Vierling double that was lost in the sun by Juan Soto, an Edmundo Sosa single, and a Kyle Schwarber grounder that was dropped by Brandon Drury, allowing Vierling to score. The Padres answered back in the bottom of the inning with home runs on back-to-back pitches from Brandon Drury and Josh Bell off of Phillies starter Aaron Nola. Nola then faced his brother Austin, who grounded out to third. In the top of the fifth, Austin singled off his brother, scoring Ha-seong Kim. Jurickson Profar then singled to advance Nola to third. The next batter, Juan Soto, doubled to right field, scoring Nola and tying the game at four. Three additional runs would score in the inning, two from a single from Drury, and one from a single from Bell to put the Padres up 7–4. In the seventh inning, Manny Machado homered off Philadelphia's David Robertson, increasing the Padres' lead to four. A first-pitch homer from Rhys Hoskins in the top of the eighth that cut down San Diego's lead to three would be the final run of the game, as Josh Hader earned the save in San Diego's first win in an NLCS game since 1998.

Game 3

Jean Segura had the go-ahead RBI single in Game 3.

Game 3 featured Philadelphia's Ranger Suarez on the mound in their first NLCS home game since 2010. San Diego countered with Joe Musgrove, who gave up a leadoff home run from Kyle Schwarber in the bottom of the first. In the top of the fourth, with runners at first and third, San Diego's Jake Cronenworth hit a ground ball to shortstop Bryson Stott. Stott threw to second baseman Jean Segura, who dropped the ball, allowing Juan Soto to score and tying the game at one. The Phillies answered in the bottom of the inning with a double from Stott after an Alec Bohm walk. Segura then singled to right center field, scoring both runners and putting the Phillies up 3–1. In the fifth inning, San Diego's Trent Grisham hit a ground ball along the first base line that was misplayed by Rhys Hoskins for a double. Ha-seong Kim then grounded out to score Grisham from third and cut the Phillies' lead to one. In the sixth inning, Bohm doubled to Soto, who dove for the ball and missed, scoring Nick Castellanos from second to raise the Phillies' lead by one. In the top of the ninth, Jurickson Profar was ejected after arguing a check swing call. Seranthony Domínguez earned the save for Philadelphia, his first-ever postseason save.

Game 4

Rhys Hoskins hit two home runs in Game 4.

Three days after the Phillies blew a 4–0 lead in Game 2, the Padres blew a 4–0 lead of their own. In the first inning, Manny Machado hit a solo home run, followed by a two-run double by Brandon Drury that pulled Philadelphia starter Bailey Falter out of the game. His replacement, Connor Brogdon, gave up a single by Ha-seong Kim that scored Drury to widen the Padres' lead to 4–0. In the bottom of the inning, Rhys Hoskins hit a two-run home run for the Phillies to cut the lead in half, followed by a run-scoring double by Bryce Harper to get Philadelphia within one run. This pulled San Diego starter Mike Clevinger out of the game, the first time two opposing starters had been pulled in the first inning of a postseason game since the 1932 World Series. In the bottom of the fourth, Bryson Stott tied the game at four, scoring Nick Castellanos. Stott was tagged out at second base. In the fifth inning, Juan Soto hit a two-run home run to give San Diego a 6–4 edge. The lead was short-lived, however. In the bottom of the inning, Hoskins hit another two-run home run off Sean Manaea to tie the game at six. This was followed by an RBI double by Harper, which gave Philadelphia the lead for the first time in the game. Castellanos hit a single that bounced off second base, scoring Harper to make it 8–6. Kyle Schwarber and J. T. Realmuto added to the scoring with solo home runs in the sixth and seventh innings off Luis Garcia and Steven Wilson, respectively. The 10–6 victory for Philadelphia pulled them within one win of going to the World Series.

Game 5

Bryce Harper hit the series-winning home run in Game 5.

Game 5 was a pitching rematch of Game 1, with Zack Wheeler on the mound for the Phillies and Yu Darvish for the Padres. In the bottom of the third with two outs, Darvish walked Kyle Schwarber. The next batter, Rhys Hoskins, followed up on his performance in Game 4 and hit a two-run home run, his third in 24 hours. The Padres prevented additional scoring after a J. T. Realmuto single when Bryce Harper flew out to end the inning. Juan Soto struck back for the Padres in the top of the fourth with a solo home run. Wheeler was chased from the game after giving up a single to Jake Cronenworth in the top of the seventh. His replacement, Seranthony Domínguez, gave up a double to Josh Bell that scored Cronenworth. Bell's pinch runner, José Azócar, advanced to third on a wild pitch. With two outs and two strikes on the batter, Trent Grisham, Domínguez threw another pitch in the dirt to score Azócar and give San Diego the lead. Grisham then flew out to end the top of the inning. In the top of the seventh, Bryson Stott doubled, removing Darvish from the game. He was replaced with Robert Suárez. After getting Jean Segura to fly out and striking out Brandon Marsh, Suárez intentionally walked Schwarber. With two outs, Hoskins flew out to end the inning. After Domínguez's disappointing performance in the seventh inning, he was replaced with José Alvarado, who walked Soto after giving up a single to Jurickson Profar. Alvarado got out of the jam by getting Manny Machado to fly out and Cronenworth to ground out.

In the bottom of the eighth, with Philadelphia still trailing by a run, Realmuto singled to left field. Harper then hit a two-run home run to left field, giving the Phillies a one-run lead.^[14] Joe Davis, who was the TV play-by-play broadcaster on FS1, described the moment as "the swing of his (Harper's) life." Scott Franzke, calling the game on Phillies radio, termed the home fans' delirious reaction "bedlam at the Bank."^[15][14] After Suárez retired the next two Phillies, David Robertson came in to close for Philadelphia, and after walking Brandon Drury and Ha-seong Kim with one out, he was taken out of the game. Ranger Suárez, who started in Game 3, was his replacement. Grisham, the next batter, bunted to advance the runners to second and third but was put out at first base. Austin Nola then flew out to Nick Castellanos, sending the Phillies to the World Series for the first time since 2009.

After the game, Harper was named the NLCS MVP, having had a .400 batting average, five runs batted in, and two home runs, including the pennant-winning two-run homer in Game 5.

Composite line score

2022 NLCS (4–1): Philadelphia Phillies beat San Diego Padres