| 2022 Winston-Salem Open | |
|---|---|
| Date | August 21–27 |
| Edition | 53rd |
| Category | ATP Tour 250 Series |
| Draw | 48S / 16D |
| Surface | Hard / outdoor |
| Location | Winston-Salem, North Carolina, U.S. |
| Venue | Wake Forest University |
| Champions | |
| Singles | |
 Adrian Mannarino | |
| Doubles | |
.svg.png.webp){kind=small} Matthew Ebden /  Jamie Murray | |
The 2022 Winston-Salem Open was a men's tennis tournament play on outdoor hard courts. It was the 53rd edition of the Winston-Salem Open (as successor to previous tournaments in New Haven and Long Island), and part of the ATP Tour 250 Series of the 2022 ATP Tour. It took place at Wake Forest University in Winston-Salem, North Carolina, United States, from August 21 through August 27, 2022. It was the last event on the 2022 US Open Series before the 2022 US Open.[1]
Champions
Singles
- Adrian Mannarino def.
Laslo Đere, 7–6(7–1), 6–4
Doubles
- Matthew Ebden / Jamie Murray def.
Hugo Nys / 
Jan Zieliński, 6–4, 6–2
Points & prize money
Point distribution
| Event | W | F | SF | QF | Round of 16 | Round of 32 | Round of 48 | Q | Q2 | Q1 |
| Singles | 250 | 150 | 90 | 45 | 20 | 10 | 0 | 5 | 3 | 0 |
|---|---|---|---|---|---|---|---|---|---|---|
| Doubles | 0 | — | — | — | — | — |
Prize money
| Event[2] | W | F | SF | QF | Round of 16 | Round of 32 | Round of 48 | Q2 | Q1 |
| Singles | $100,475 | $57,660 | $33,115 | $19,125 | $10,925 | $6,420 | $3,905 | $2,070 | $1,145 |
| Doubles* | $39,530 | $20,700 | $11,690 | $6,780 | $4,000 | — | — | — | — |
*per team
Singles main-draw entrants
Seeds
| Country | Player | Rank† | Seed |
|---|---|---|---|
 BUL |
Grigor Dimitrov | 18 | 1 |
 NED |
Botic van de Zandschulp | 24 | 2 |
 DEN |
|||
 USA |
Maxime Cressy | 32 | 4 |
 ITA |
Lorenzo Musetti | 33 | 5 |
 GEO |
Nikoloz Basilashvili | 34 | 6 |
 ARG |
|||
 ESP |
Albert Ramos Viñolas | 40 | 8 |
 FIN |
Emil Ruusuvuori | 44 | 9 |
| FRA |
Benjamin Bonzi | 48 | 10 |
 |
Ilya Ivashka | 49 | 11 |
| ESP |
Pedro Martínez | 53 | 12 |
| GBR |
Jack Draper | 55 | 13 |
| ITA |
Lorenzo Sonego | 56 | 14 |
| ESP |
Jaume Munar | 57 | 15 |
 POR |
João Sousa | 59 | 16 |
† Rankings are as of 15 August 2022.
Other entrants
The following players received wildcard entry into the singles main draw:
The following players received entry using a protected ranking:
The following players received entry from the qualifying draw:
.svg.png.webp){kind=small}
The following players received entry as lucky losers:
Withdrawals
- Before the tournament
- Sebastián Báez → replaced by
Márton Fucsovics 
Alexander Bublik → replaced by Adrian Mannarino- Pablo Carreño Busta → replaced by
Taro Daniel .svg.png.webp)
Hugo Dellien → replaced by Shintaro Mochizuki- Tomás Martín Etcheverry → replaced by
Michail Pervolarakis - Marcos Giron → replaced by
Peter Gojowczyk - Quentin Halys → replaced by Denis Kudla
Alex Molčan → replaced by John Millman- Brandon Nakashima → replaced by Jack Draper
- Oscar Otte → replaced by Richard Gasquet
- Tommy Paul → replaced by Dušan Lajović
- Holger Rune → replaced by Tallon Griekspoor
- Frances Tiafoe → replaced by Steve Johnson
Doubles main-draw entrants
Seeds
| Country | Player | Country | Player | Rank† | Seed |
|---|---|---|---|---|---|
 CRO |
Nikola Mektić | CRO |
Mate Pavić | 23 | 1 |
| CRO |
Ivan Dodig | USA |
Austin Krajicek | 31 | 2 |
| AUS |
Matthew Ebden | GBR |
Jamie Murray | 54 | 3 |
| GBR |
Lloyd Glasspool | FIN |
Harri Heliövaara | 56 | 4 |
† Rankings are as of 15 August 2022.
Other entrants
The following pairs received wildcard entry into the doubles main draw :
Withdrawals
Marcelo Arévalo / Jean-Julien Rojer → replaced by Hugo Nys / Jan Zieliński- Matthew Ebden / Max Purcell → replaced by Matthew Ebden / Jamie Murray
Santiago González / Andrés Molteni → replaced by Aleksandr Nedovyesov / 
Aisam-ul-Haq Qureshi- Wesley Koolhof / Neal Skupski → replaced by Fabrice Martin / Jonny O'Mara
- Kevin Krawietz / Andreas Mies → replaced by
.svg.png.webp)
Sander Gillé / Joran Vliegen - Jamie Murray /
Bruno Soares → replaced by Nathaniel Lammons / Jackson Withrow