3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase
Identifiers
EC no.1.14.14.12
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
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NCBIproteins

3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase (EC 1.14.14.12, HsaA) is an enzyme with systematic name 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione,FMNH2:oxygen oxidoreductase.[1] This enzyme catalyses the following chemical reaction:

3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H2O

This bacterial enzyme participates in the degradation of several steroids, including cholesterol and testosterone.

References

  1. Dresen C, Lin LY, D'Angelo I, Tocheva EI, Strynadka N, Eltis LD (July 2010). "A flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolism". The Journal of Biological Chemistry. 285 (29): 22264–75. doi:10.1074/jbc.M109.099028. PMC 2903365. PMID 20448045.
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