ACIN1

ACIN1
Identifiers
Aliases	ACIN1, ACINUS, ACN, fSAP152, apoptotic chromatin condensation inducer 1
External IDs	OMIM: 604562 MGI: 1891824 HomoloGene: 22853 GeneCards: ACIN1
Gene location (Human)
Chr.	Chromosome 14 (human)
End	23,095,614 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	54,686,931 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right lobe of thyroid gland; ; sural nerve; ; left lobe of thyroid gland; ; canal of the cervix; ; anterior pituitary; ; ganglionic eminence; ; gastric mucosa; ; left uterine tube; ; stromal cell of endometrium;
	Top expressed in
	yolk sac; ; superior frontal gyrus; ; lip; ; thymus; ; cerebellar cortex; ; ganglionic eminence; ; abdominal wall; ; spermatocyte; ; lacrimal gland; ; internal carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ATPase activity; protein binding; enzyme binding; nucleic acid binding; RNA binding;
Cellular component	nuclear speck; plasma membrane; exon-exon junction complex; nucleoplasm; nucleolus; ASAP complex; nucleus; cytosol;
Biological process	apoptotic chromosome condensation; mRNA processing; negative regulation of mRNA splicing, via spliceosome; RNA splicing; positive regulation of apoptotic process; positive regulation of monocyte differentiation; erythrocyte differentiation; apoptotic process; execution phase of apoptosis;
	Sources:Amigo / QuickGO
Orthologs
	22985
	56215
	ENSG00000100813
	ENSMUSG00000022185
	Q9UKV3
	Q9JIX8
NM_001164814; NM_001164815; NM_001164816; NM_001164817; NM_014977;
	NM_001386863
NM_001085472; NM_001085473; NM_001242605; NM_001242606; NM_019567;
	NM_023190
	NP_001158286; NP_001158287; NP_001158288; NP_001158289; NP_055792
NP_001078941; NP_001078942; NP_001229534; NP_001229535; NP_062513;
	NP_075679; NP_001361699
	Wikidata
View/Edit Human	View/Edit Mouse

Apoptotic chromatin condensation inducer in the nucleus is a protein that in humans is encoded by the ACIN1 gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000100813 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022185 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
↑ Sahara S, Aoto M, Eguchi Y, Imamoto N, Yoneda Y, Tsujimoto Y (Sep 1999). "Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation". Nature. 401 (6749): 168–73. Bibcode:1999Natur.401..168S. doi:10.1038/43678. PMID 10490026. S2CID 4364282.
↑ "Entrez Gene: ACIN1 apoptotic chromatin condensation inducer 1".

External links

Human ACIN1 genome location and ACIN1 gene details page in the UCSC Genome Browser.

Zermati Y, Garrido C, Amsellem S, et al. (2001). "Caspase activation is required for terminal erythroid differentiation". J. Exp. Med. 193 (2): 247–54. doi:10.1084/jem.193.2.247. PMC 2193347. PMID 11208865.
Sordet O, Rébé C, Plenchette S, et al. (2003). "Specific involvement of caspases in the differentiation of monocytes into macrophages". Blood. 100 (13): 4446–53. doi:10.1182/blood-2002-06-1778. PMID 12393560.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Shu H, Chen S, Bi Q, et al. (2004). "Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line". Mol. Cell. Proteomics. 3 (3): 279–86. doi:10.1074/mcp.D300003-MCP200. PMID 14729942.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
Hu Y, Yao J, Liu Z, et al. (2005). "Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation". EMBO J. 24 (20): 3543–54. doi:10.1038/sj.emboj.7600823. PMC 1276706. PMID 16177823.
Joselin AP, Schulze-Osthoff K, Schwerk C (2006). "Loss of Acinus inhibits oligonucleosomal DNA fragmentation but not chromatin condensation during apoptosis". J. Biol. Chem. 281 (18): 12475–84. doi:10.1074/jbc.M509859200. PMID 16537548.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Shu Y, Iijima T, Sun W, et al. (2007). "The ACIN1 gene is hypermethylated in early stage lung adenocarcinoma". Journal of Thoracic Oncology. 1 (2): 160–7. doi:10.1097/01243894-200602000-00010. PMID 17409846.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000100813 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022185 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9734811-5] Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.

[pmid10490026-6] Sahara S, Aoto M, Eguchi Y, Imamoto N, Yoneda Y, Tsujimoto Y (Sep 1999). "Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation". Nature. 401 (6749): 168–73. Bibcode:1999Natur.401..168S. doi:10.1038/43678. PMID 10490026. S2CID 4364282.

[entrez-7] "Entrez Gene: ACIN1 apoptotic chromatin condensation inducer 1".

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[2]

[3]

[4]

[5]

[6]

[7]

References

External links

Further reading