ADE
Specialtyoncology

ADE is a chemotherapy regimen most often used as an induction or consolidation regimen in acute myelogenous leukemia, especially in poor-risk patients or those refractory to the standard first-line induction with standard "7+3" regimen or who are relapsed after the standard chemotherapy.

ADE regimen consists of three drugs:

  1. Ara-C (cytarabine) - an antimetabolite;
  2. Daunorubicin - an anthracycline antibiotic that is able to intercalate DNA and thus disrupt the cell division cycle, preventing mitosis;
  3. Etoposide - a topoisomerase inhibitor.[1]

Dosing regimen

DrugDoseModeDays
Ara-C (cytarabine)200 mg/m2IV push every 12 hours in 2 divided doses (100 mg/m2 each)Days 1-10
Daunorubicin50 mg/m2IV slow pushDays 1, 3 and 5
Etoposide100 mg/m2IV infusion over 1 hourDays 1-5

References

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