AKAP7

AKAP7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ZP3
Identifiers
Aliases	AKAP7, AKAP15, AKAP18, A-kinase anchoring protein 7
External IDs	OMIM: 604693 MGI: 1859150 HomoloGene: 49463 GeneCards: AKAP7
Gene location (Human)
Chr.	Chromosome 6 (human)
End	131,283,535 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	25,183,768 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; left adrenal gland; ; right adrenal gland; ; duodenum; ; pancreatic epithelial cell; ; biceps brachii; ; endothelial cell; ; germinal epithelium; ; Achilles tendon; ; islet of Langerhans;
	Top expressed in
	cerebellar vermis; ; secondary oocyte; ; jejunum; ; duodenum; ; primary motor cortex; ; brown adipose tissue; ; superior frontal gyrus; ; parotid gland; ; interventricular septum; ; otolith organ;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein kinase A binding; protein binding; nucleotide binding; protein kinase binding; protein kinase A regulatory subunit binding;
Cellular component	plasma membrane; apical plasma membrane; lateral plasma membrane; membrane; intracellular anatomical structure; cytoplasm; cytosol; nucleus; protein-containing complex; hippocampal mossy fiber to CA3 synapse;
Biological process	action potential; protein localization; regulation of membrane repolarization; intracellular signal transduction; ion transport; cellular response to cAMP; positive regulation of delayed rectifier potassium channel activity; positive regulation of potassium ion transmembrane transport; regulation of protein kinase A signaling; biological process; modulation of chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	9465
	432442
	ENSG00000118507
	ENSMUSG00000039166
	O43687; Q9P0M2
	O55074; Q7TN79
NM_004842; NM_016377; NM_138633; NM_001376570; NM_001387860;
	NM_001387861; NM_001387862; NM_001387863; NM_001387864
	NM_018747; NM_001347460; NM_001379238; NM_001379239; NM_001379240
	NP_004833; NP_057461; NP_619539; NP_001363499; NP_057461.2
NP_001334389; NP_061217; NP_001366167; NP_001366168; NP_001366169;
	NP_061217.3
	Wikidata
View/Edit Human	View/Edit Mouse

A-kinase anchor protein 7 isoform gamma is an enzyme that in humans is encoded by the AKAP7 gene.^[5]^[6]

Function

This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000118507 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039166 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Fraser ID, Tavalin SJ, Lester LB, Langeberg LK, Westphal AM, Dean RA, Marrion NV, Scott JD (Apr 1998). "A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events". The EMBO Journal. 17 (8): 2261–2272. doi:10.1093/emboj/17.8.2261. PMC 1170570. PMID 9545239.
1 2 "Entrez Gene: AKAP7 A kinase (PRKA) anchor protein 7".

External links

Human AKAP7 genome location and AKAP7 gene details page in the UCSC Genome Browser.

Gold MG, Smith FD, Scott JD, Barford D (Feb 2008). "AKAP18 contains a phosphoesterase domain that binds AMP". Journal of Molecular Biology. 375 (5): 1329–1343. doi:10.1016/j.jmb.2007.11.037. PMC 3188456. PMID 18082768.
Bengrine A, Li J, Awayda MS (Apr 2007). "The A-kinase anchoring protein 15 regulates feedback inhibition of the epithelial Na+ channel". FASEB Journal. 21 (4): 1189–1201. doi:10.1096/fj.06-6046com. PMID 17244820. S2CID 34457423.
Brown RL, August SL, Williams CJ, Moss SB (Jun 2003). "AKAP7gamma is a nuclear RI-binding AKAP". Biochemical and Biophysical Research Communications. 306 (2): 394–401. doi:10.1016/S0006-291X(03)00982-3. PMID 12804576.
Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD (Apr 2003). "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring". Proceedings of the National Academy of Sciences of the United States of America. 100 (8): 4445–4450. Bibcode:2003PNAS..100.4445A. doi:10.1073/pnas.0330734100. PMC 153575. PMID 12672969.
Trotter KW, Fraser ID, Scott GK, Stutts MJ, Scott JD, Milgram SL (Dec 1999). "Alternative splicing regulates the subcellular localization of A-kinase anchoring protein 18 isoforms". The Journal of Cell Biology. 147 (7): 1481–1492. doi:10.1083/jcb.147.7.1481. PMC 2174236. PMID 10613906.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000118507 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039166 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9545239-5] Fraser ID, Tavalin SJ, Lester LB, Langeberg LK, Westphal AM, Dean RA, Marrion NV, Scott JD (Apr 1998). "A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events". The EMBO Journal. 17 (8): 2261–2272. doi:10.1093/emboj/17.8.2261. PMC 1170570. PMID 9545239.

[entrez-6] 1 2 "Entrez Gene: AKAP7 A kinase (PRKA) anchor protein 7".

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[5]

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Function

References

External links

Further reading