ARGLU1
Identifiers
AliasesARGLU1, arginine and glutamate rich 1
External IDsOMIM: 614046 MGI: 2442985 HomoloGene: 9960 GeneCards: ARGLU1
Orthologs
SpeciesHumanMouse
Entrez

55082

234023

Ensembl

ENSG00000134884

ENSMUSG00000040459

UniProt

Q9NWB6

Q3UL36

RefSeq (mRNA)

NM_018011

NM_176849

RefSeq (protein)

NP_060481

NP_789819

Location (UCSC)Chr 13: 106.54 – 106.57 MbChr 8: 8.72 – 8.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Arginine and glutamate-rich protein 1 is a protein that in humans is encoded by the ARGLU1 gene located at 13q33.3.[5]

The protein product of this gene has been proposed as a MED1-interacting protein required for estrogen-dependent gene transcription and breast cancer cell growth.[6]

The ARGLU1 gene expresses at least three distinct RNA splice isoforms - a fully spliced isoform coding for the protein, an isoform containing a retained intron that is detained in the nucleus, and an isoform containing an alternative exon that targets the transcript for nonsense mediated decay. Furthermore, ARGLU1 contains a long, highly evolutionarily conserved sequence known as an Ultraconserved Element (UCE) that is within the retained intron and overlaps the alternative exon. [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000134884 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040459 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ "Entrez Gene: ARGLU1 arginine and glutamate rich 1".
  6. ↑ Zhang D, Jiang P, Xu Q, Zhang X (May 2011). "Arginine and glutamate-rich 1 (ARGLU1) interacts with mediator subunit 1 (MED1) and is required for estrogen receptor-mediated gene transcription and breast cancer cell growth". J. Biol. Chem. 286 (20): 17746–54. doi:10.1074/jbc.M110.206029. PMC 3093850. PMID 21454576.
  7. ↑ Pirnie SP, Osman A, Zhu Y, Carmichael GG (April 2017). "An Ultraconserved Element (UCE) controls homeostatic splicing of ARGLU1 mRNA". Nucleic Acids Res. 45 (6): 3473–3486. doi:10.1093/nar/gkw1140. PMC 5389617. PMID 27899669.
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