ARHGAP9

ARHGAP9
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2P0D, 2P0H
Identifiers
Aliases	ARHGAP9, 10C, RGL1, Rho GTPase activating protein 9
External IDs	OMIM: 610576 MGI: 2143764 HomoloGene: 13041 GeneCards: ARHGAP9
Gene location (Human)
Chr.	Chromosome 12 (human)
End	57,488,814 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	127,165,812 bp
RNA expression pattern
	Top expressed in
	blood; ; spleen; ; appendix; ; monocyte; ; lymph node; ; bone marrow; ; bone marrow cells; ; spongy bone; ; thymus; ; right lung;
	Top expressed in
	blood; ; thymus; ; bone marrow; ; spleen; ; submandibular gland; ; parotid gland; ; subcutaneous adipose tissue; ; hair follicle; ; pharynx; ; carotid body;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; phosphatidylinositol-3,4,5-trisphosphate binding; lipid binding; GTPase activator activity;
Cellular component	cytosol; extracellular region; secretory granule lumen; cytoplasm;
Biological process	regulation of small GTPase mediated signal transduction; signal transduction; positive regulation of GTPase activity; neutrophil degranulation; regulation of GTPase activity;
	Sources:Amigo / QuickGO
Orthologs
	64333
	216445
	ENSG00000123329
	ENSMUSG00000040345
	Q9BRR9
	n/a
NM_001080156; NM_001080157; NM_032496; NM_001319850; NM_001319851;
	NM_001319852; NM_001367422; NM_001367423; NM_001367424; NM_001367425; NM_001367426
	NM_001285785; NM_146011; NM_001359656; NM_001359657
NP_001073625; NP_001073626; NP_001306779; NP_001306780; NP_001306781;
	NP_115885; NP_001354351; NP_001354352; NP_001354353; NP_001354354; NP_001354355; NP_001306779.1
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Rho GTPase-activating protein 9 is an enzyme that in humans is encoded by the ARHGAP9 gene.^[5]^[6]

Function

This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000123329 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040345 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Furukawa Y, Kawasoe T, Daigo Y, Nishiwaki T, Ishiguro H, Takahashi M, Kitayama J, Nakamura Y (Jun 2001). "Isolation of a novel human gene, ARHGAP9, encoding a rho-GTPase activating protein". Biochemical and Biophysical Research Communications. 284 (3): 643–9. doi:10.1006/bbrc.2001.5022. PMID 11396949.
1 2 "Entrez Gene: ARHGAP9 Rho GTPase activating protein 9".

External links

Human ARHGAP9 genome location and ARHGAP9 gene details page in the UCSC Genome Browser.
Human RGL1 genome location and RGL1 gene details page in the UCSC Genome Browser.

Peck J, Douglas G, Wu CH, Burbelo PD (Sep 2002). "Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships". FEBS Letters. 528 (1–3): 27–34. doi:10.1016/S0014-5793(02)03331-8. PMID 12297274. S2CID 30443852.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000123329 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040345 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11396949-5] Furukawa Y, Kawasoe T, Daigo Y, Nishiwaki T, Ishiguro H, Takahashi M, Kitayama J, Nakamura Y (Jun 2001). "Isolation of a novel human gene, ARHGAP9, encoding a rho-GTPase activating protein". Biochemical and Biophysical Research Communications. 284 (3): 643–9. doi:10.1006/bbrc.2001.5022. PMID 11396949.

[entrez-6] 1 2 "Entrez Gene: ARHGAP9 Rho GTPase activating protein 9".

[1]

[2]

[3]

[4]

[5]

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Function

References

External links

Further reading