ARL1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARL1, ARFL1, ADP ribosylation factor like GTPase 1
External IDsOMIM: 603425 MGI: 99436 HomoloGene: 20319 GeneCards: ARL1
Orthologs
SpeciesHumanMouse
Entrez

400

104303

Ensembl

ENSG00000120805

ENSMUSG00000060904

UniProt

P40616

P61211

RefSeq (mRNA)

NM_001301068
NM_001177

NM_025859

RefSeq (protein)

NP_001168
NP_001287997

NP_080135

Location (UCSC)Chr 12: 101.39 – 101.41 MbChr 10: 88.57 – 88.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ADP-ribosylation factor-like protein 1 is a protein that in humans is encoded by the ARL1 gene.[5]

Function

The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner.[5]

Interactions

ARL1 has been shown to interact with GOLGA4[6][7] and GOLGA1.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000120805 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000060904 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: ARL1 ADP-ribosylation factor-like 1".
  6. 1 2 Lu L, Hong W (September 2003). "Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi". Mol. Biol. Cell. 14 (9): 3767–81. doi:10.1091/mbc.E03-01-0864. PMC 196566. PMID 12972563.
  7. Van Valkenburgh H, Shern JF, Sharer JD, Zhu X, Kahn RA (June 2001). "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins". J. Biol. Chem. 276 (25): 22826–37. doi:10.1074/jbc.M102359200. PMID 11303027.

Further reading


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