Aceglatone
Clinical data
Trade namesGlucaron
Other namesD-Glucaric acid di-γ-lactone 2,5-diacetate
2,5-Di-O-acetyl-D-glucaro-1,4:6,3-dilactone
2,5-Di-O-acetyl-D-glucosaccharo-1,4:6,3-dilactone
AHFS/Drugs.comInternational Drug Names
ATC code
  • none
Identifiers
  • (3R,3aR,6S,6aR)-2,5-Dioxohexahydrofuro[3,2-b]furan-3,6-diyl diacetate
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC10H10O8
Molar mass258.182 g·mol−1
3D model (JSmol)
Melting point185 to 186 °C (365 to 367 °F) [1]
  • O=C1O[C@H]2[C@@H](OC(=O)C)C(=O)O[C@H]2[C@@H]1OC(=O)C
  • InChI=1S/C10H10O8/c1-3(11)15-7-5-6(18-9(7)13)8(10(14)17-5)16-4(2)12/h5-8H,1-2H3/t5-,6-,7-,8+/m1/s1 checkY
  • Key:ZOZKYEHVNDEUCO-XUTVFYLZSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Aceglatone (Glucaron) is an antineoplastic drug available in Japan.[2]

It is an inhibitor of the enzyme β-glucuronidase.[3]

References

  1. ↑ Merck Index, 11th Edition, 20
  2. ↑ Glucaron, drugs.com
  3. ↑ Iida R, Nagata S, Kakimoto M, Akaike H, Watanabe H, Shioya A (1965). "2,5-Di-O-acetyl-D-glucosaccharo-(1→4)(6→3)-dilactone, a new potent β-glucuronidase inhibitor". Japanese Journal of Pharmacology. 15 (1): 88–90. doi:10.1254/jjp.15.88. PMID 14348597.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.