Adrian M. Owen

OBE
Adrian Owen lecturing in 2016
Born
Adrian Mark Owen

(1966-05-17)17 May 1966
Gravesend, Kent, U.K.
NationalityBritish & Canadian
EducationGravesend Grammar School
Alma mater
Scientific career
Institutions
Websiteowenlab.uwo.ca

Adrian Mark Owen OBE (born 17 May 1966) is a British neuroscientist and best-selling author.[1] He is best known for his 2006 discovery, published in the journal Science, showing that some patients thought to be in a persistent vegetative state are in fact fully aware and (shown subsequently) able to communicate with the outside world using functional magnetic resonance imaging (fMRI). In the 2019 New Year Honours List, Owen was made an Officer of the Most Excellent Order of the British Empire (OBE) for services to scientific research.

Early life and education

Adrian Owen was born 17 May 1966 in Gravesend, England, and educated at Gravesend Grammar School, graduating in the same final year class as actor Paul Ritter. His first degree was in Psychology from University College London 1985–1988. As a student he shared accommodation with Psychologist and best-selling author Richard Wiseman. Owen completed his PhD at the Institute of Psychiatry, London (now part of King's College London) between 1988 and 1992.

Career

In 1992, Owen began his post-doctoral research in the Cognitive Neuroscience Unit at the Montreal Neurological Institute, McGill University, working with Michael Petrides and Brenda Milner. He was awarded The Pinsent Darwin Scholarship by the University of Cambridge in 1996 and returned to the UK to work at the newly opened Wolfson Brain Imaging Centre, Cambridge. In 1997 he moved to the Medical Research Council's Cognition and Brain Sciences Unit (CBU), Cambridge (formally the Applied Psychology Unit) to set up the neuroimaging programme there and to pursue his research in cognitive neuroscience. He was awarded MRC tenure in 2000 and made Assistant Director of the MRC CBU in 2005, with overall responsibility for the onsite imaging facilities (3T Siemens Tim Trio MRI and 306-channel Elekta-Neuromag MEG systems).

In 2010, Owen was awarded a $10M Canada Excellence Research Chair in Cognitive Neuroscience and Imaging at The University of Western Ontario (UWO)[2] and moved most of his research team to Canada in order to take up this position in January 2011.[3]

In October 2019 Owen was the guest for the BBC Radio 4 programme The Life Scientific.[4]

Research

Over the last 30 years, Owen has published more than 400 peer-reviewed scientific papers and over 40 chapters and books.[5] His work has appeared in many of the world's most prestigious scientific and medical journals, including Science, Nature, The Lancet and The New England Journal of Medicine. He has an h-Index of 119 according to Google Scholar.[6]

His early publications on patients with frontal or temporal-lobe excisions[7][8][9][10][11][12] pioneered the use of touch screen based computerised cognitive tests in neuropsychology. Over the last 30 years, these tests have gone on to be used in more than 600 published studies of Parkinson's disease, Alzheimer's disease, Huntington's disease, Depression, Schizophrenia, Autism, Obsessive-Compulsive Disorder and ADHD, among others.

His post-doctoral research on working memory with Michael Petrides, (PNAS, Cerebral Cortex, Journal of Cognitive Neuroscience, Brain and others) was instrumental in refuting the then prevailing view of lateral frontal-lobe organisation advanced by Patricia Goldman-Rakic and others, and is still widely cited in that context. His 1996 paper on the organisation of working memory processes within the human frontal lobe continues to be one of the most highly cited articles ever to appear in the scientific journal Cerebral Cortex.[13]

His 2006 paper in the journal Science[14] demonstrated for the first time that functional neuroimaging could be used to detect awareness in patients who are incapable of generating any recognised behavioural response and appear to be in a vegetative state. This landmark discovery has had implications for clinical care, diagnosis, medical ethics and medical/legal decision-making (relating to the prolongation, or otherwise, of life after severe brain injury).[7][15][16][17] In a follow-up paper in 2010 in The New England Journal of Medicine,[18] Owen and his team used a similar method to allow a man believed to be in a vegetative state for more than 5 years to answer 'yes' and 'no' questions with responses that were generated solely by changing his brain activity using fMRI.[19]

This research attracted international attention from the world's media; it was reported in many hundreds of newspapers around the world (including twice on the front page of The New York Times and other quality journals) and has been widely discussed on television (e.g. BBC News,[20] Channel 4 News, ITN News, Sky News,[21] CNN[22]), radio (e.g. BBC World Service[23]) 'Outlook' documentary, NPR Radio (USA), BBC Radio 1, 2, 3 and 4), in print (e.g. full featured articles in The New Yorker[24] The Times, The Sunday Times, The Observer Magazine etc.) and online (including Nature, Science and The Guardian podcasts). To date, the discovery has featured prominently in 6 television documentaries including 60 Minutes (USA),[25] Panorama BBC Special Report (UK),[26] Inside Out (BBC TV series) (UK),[27] and CBC The National (Canada).[28]

In 2009, Owen launched Cambridge Brain Sciences,[29] a web-based platform for healthcare providers and the wider scientific community to assess cognitive function using scientifically proven tests of memory, attention, reasoning and planning. In 2023, the company changed its name to Creyos. To date, the tests on the site have been taken more than 14 million times by people worldwide.

In April 2010, Owen and his team published the largest ever public test of computer-based brain training in the journal Nature.[30] The study, conducted in conjunction with the BBC, showed that practice on brain training games does not transfer to other mental skills. More than 11,000 adults followed a six-week training regime, completing computer-based tasks on the BBC's website designed to improve reasoning, memory, planning, visuospatial skills and attention.[31] Details of the results were revealed on BBC1 in Can You Train Your Brain?, a Bang Goes the Theory special and published on the same day in Nature.[32]

In November 2011, Owen led a study that was published in a weekly peer-reviewed medical journal, The Lancet.[33] The Researchers found a method for assessing whether or not some patients who appear to be vegetative, are in fact, conscious and are just not able to respond. This new method is using electroencephalography (EEG), which is not only less expensive than MRI, but is also portable and can be taken right to the patients bedside for testing.[34][35]

Book

In June 2017, Owen published 'Into The Gray Zone: A Neuroscientist Explores the Border Between Life and Death'[36] a popular science book that told the story of his 20-year quest to show that some patients thought to be in a vegetative state were in fact entirely aware, but incapable of indicating their awareness to the outside world. The book became a best-seller on both sides of the Atlantic and received strong positive reviews from publications including Nature, The Guardian, and The New York Times. The book made Sunday Times 'Book of The Year',[37] and The Times 'Book of The Week', it was listed on The New Yorker list 'What We're Reading This Summer'[38] and received 4.9 out of 5 stars on Amazon.[39] The book was translated into multiple languages, including Italian, French, Russian, German, Taiwanese, Japanese, Czech and Polish.

Other academic roles

Owen served as Deputy Editor-in-Chief of the European Journal of Neuroscience from 1997 to 2005 and as an Associate Editor of the Journal of Neuroscience from 2006 to 2012. He was a member of the Neurosciences and Mental Health Committee of the Wellcome Trust in the UK from 2007 to 2012, and of the Gairdner Medical Review Panel in Canada from 2012 to 2017. Since 2007, 2012, and 2014, respectively, he has served on the advisory Board of the Annals of the New York Academy of Sciences, as a member of the Wellcome Trust Peer Review Panel, and as a member of the Peer Review Committee for the Canadian Institutes of Health Research.

Owen has also held or holds affiliations with several universities and committees on neuroscience, neuroethics, psychiatry, and philosophy, including the Institute of Psychiatry, Robarts Research Institute, and the International Scientific Committee for the Institute of Cognitive Neurology (INECO).

Personal life

Owen lives in London, Ontario with his wife, Emily Nichols who is also a Neuroscientist, and has one son, Jackson. His sister, Frances Walsh is Safeguarding Nurse for the NHS, in Warwickshire, England.

For the past twenty-years, Owen has played guitar and sung in various bands made up of fellow scientists and musicians.[40]

References

  1. ↑ Owen, Adrian (20 June 2017). Into The Gray Zone: A Neuroscientist Explores the Border Between Life and Death. New York: Scribner. ISBN 9781501135217.
  2. ↑ "Adrian Owen". Canada Excellence Research Chairs. 29 November 2012. Retrieved 13 April 2016.
  3. ↑ Travis, Heather (27 May 2010). "One of Britain's best picks Western". Western News. Retrieved 13 April 2016.
  4. ↑ "BBC Radio 4 - the Life Scientific, Adrian Owen on scanning for awareness in the injured brain".
  5. ↑ "Publications - Owen Lab". Western University. Retrieved 13 April 2016.
  6. ↑ "Google Scholar - Adrian Owen". 19 June 2021. Archived from the original on 29 November 2014.
  7. 1 2 Owen, Adrian M; Coleman, Martin R (2007). "Functional MRI in disorders of consciousness: advantages and limitations". Current Opinion in Neurology. 20 (6): 632–7. doi:10.1097/WCO.0b013e3282f15669. PMID 17992081. S2CID 18457992.
  8. ↑ Owen, A; Downes, JJ; Sahakian, BJ; Polkey, CE; Robbins, TW (1990). "Planning and spatial working memory following frontal lobe lesions in man". Neuropsychologia. 28 (10): 1021–34. doi:10.1016/0028-3932(90)90137-D. PMID 2267054. S2CID 25223617.
  9. ↑ Owen, A; Roberts, AC; Polkey, CE; Sahakian, BJ; Robbins, TW (1991). "Extra-dimensional versus intra-dimensional set shifting performance following frontal lobe excisions, temporal lobe excisions or amygdalo-hippocampectomy in man". Neuropsychologia. 29 (10): 993–1006. doi:10.1016/0028-3932(91)90063-E. PMID 1762678. S2CID 43802468.
  10. ↑ Owen, A. M.; James, M.; Leigh, P. N.; Summers, B. A.; Marsden, C. D.; Quinn, N. P.; Lange, K. W.; Robbins, T. W. (1992). "Fronto-Striatal Cognitive Deficits at Different Stages of Parkinson's Disease" (PDF). Brain. 115 (6): 1727–51. doi:10.1093/brain/115.6.1727. PMID 1486458.
  11. ↑ Owen, A; Sahakian, BJ; Semple, J; Polkey, CE; Robbins, TW (1995). "Visuo-spatial short-term recognition memory and learning after temporal lobe excisions, frontal lobe excisions or amygdalo-hippocampectomy in man". Neuropsychologia. 33 (1): 1–24. doi:10.1016/0028-3932(94)00098-A. PMID 7731533. S2CID 37994751.
  12. ↑ Owen, Adrian M.; Morris, Robin G.; Sahakian, Barbara J.; Polkey, Charles E.; Robbins, Trevor W. (1996). "Double dissociations of memory and executive functions in working memory tasks following frontal lobe excisions, temporal lobe excisions or amygdalo-hippocampectomy in man". Brain. 119 (5): 1597–615. doi:10.1093/brain/119.5.1597. PMID 8931583.
  13. ↑ Owen, Adrian M.; Evans, Alan C.; Petrides, Michael (1996). "Evidence for a Two-Stage Model of Spatial Working Memory Processing within the Lateral Frontal Cortex: A Positron Emission Tomography Study". Cerebral Cortex. 6 (1): 31–8. doi:10.1093/cercor/6.1.31. PMID 8670636.
  14. ↑ Owen, Adrian M.; Coleman, Martin R. (2008). "Detecting Awareness in the Vegetative State" (PDF). Annals of the New York Academy of Sciences. 1129 (1): 130–8. Bibcode:2008NYASA1129..130O. doi:10.1196/annals.1417.018. hdl:2268/130307. PMID 18591475. S2CID 7536451.
  15. ↑ Fins, JJ; Schiff, ND (2006). "Shades of Gray: New Insights into the Vegetative State". Hastings Center Report. 36 (6): 8. doi:10.1353/hcr.2006.0094. PMID 17278863. S2CID 977538.
  16. ↑ Owen, Adrian M.; Coleman, Martin R. (2008). "Functional neuroimaging of the vegetative state". Nature Reviews Neuroscience. 9 (3): 235–43. doi:10.1038/nrn2330. PMID 18285801. S2CID 18598803.
  17. ↑ Owen, AM; Coleman, MR (2008). "Using neuroimaging to detect awareness in disorders of consciousness". Functional Neurology. 23 (4): 189–94. PMID 19331781.
  18. ↑ Monti, Martin M.; Vanhaudenhuyse, Audrey; Coleman, Martin R.; Boly, Melanie; Pickard, John D.; Tshibanda, Luaba; Owen, Adrian M.; Laureys, Steven (2010). "Willful Modulation of Brain Activity in Disorders of Consciousness". New England Journal of Medicine. 362 (7): 579–89. doi:10.1056/NEJMoa0905370. PMID 20130250. S2CID 13358991.
  19. ↑ Boseleys, S "Think tennis for yes, home for no: how doctors helped man in vegetative state" The Guardian, 3 February 2010.
  20. ↑ "Scan unlocks vegetative patients". BBC. 3 February 2010. Retrieved 13 April 2016.
  21. ↑ Borland, Huw (4 February 2010). "'Vegetative' Man 'Talks' Using His Thoughts". Sky News. Archived from the original on 9 May 2016. Retrieved 13 April 2016.
  22. ↑ Wilkinson, Peter (9 February 2010). "'Vegetative state' man responds to questions". CNN. Retrieved 13 April 2016.
  23. ↑ "Listen to Dr Adrian Owen". BBC World Service. 4 February 2010. Retrieved 13 April 2016.
  24. ↑ Groopman, Jerome (15 October 2007). "Silent Minds". The New Yorker. ISSN 0028-792X. Retrieved 13 April 2016.
  25. ↑ cambridgebrainsciences.com (14 April 2014), Vegetative State, retrieved 13 April 2016
  26. ↑ "The Mind Reader - Unlocking My Voice". Dailymotion. Retrieved 13 April 2016.
  27. ↑ cambridgebrainsciences.com (23 February 2009), InsideOut, retrieved 13 April 2016
  28. ↑ cambridgebrainsciences.com (15 November 2012), Vegetative state brain scanning breakthrough, retrieved 13 April 2016
  29. ↑ "Cambridge Brain Sciences".
  30. ↑ Owen, Adrian M.; Hampshire, Adam; Grahn, Jessica A.; Stenton, Robert; Dajani, Said; Burns, Alistair S.; Howard, Robert J.; Ballard, Clive G. (2010). "Putting brain training to the test". Nature. 465 (7299): 775–8. Bibcode:2010Natur.465..775O. doi:10.1038/nature09042. PMC 2884087. PMID 20407435.
  31. ↑ Rutherford, Adam (20 April 2010). "Brain-training games don't work". The Guardian. ISSN 0261-3077. Retrieved 13 April 2016.
  32. ↑ Katsnelson, Alla (20 April 2010). "No gain from brain training". Nature News. 464 (7292): 1111. doi:10.1038/4641111a. PMID 20414280.
  33. ↑ Cruse, Damian; Chennu, Srivas; Chatelle, Camille; Bekinschtein, Tristan A.; Fernández-Espejo, Davinia; Pickard, John D.; Laureys, Steven; Owen, Adrian M. (17 December 2011). "Bedside detection of awareness in the vegetative state: a cohort study". Lancet. 378 (9809): 2088–2094. CiteSeerX 10.1.1.368.3928. doi:10.1016/S0140-6736(11)61224-5. ISSN 1474-547X. PMID 22078855. S2CID 1926221.
  34. ↑ Goldfine; Victor; Conte; Bardin; Schiff (2013). "Reanalysis of "Bedside detection of awareness in the vegetative state"". Lancet. 381 (9863): 289–91. doi:10.1016/s0140-6736(13)60125-7. PMC 3641526. PMID 23351802.
  35. ↑ Cruse, D; Chennu, S; Chatelle, C; Bekinschtein, TA; Fernández-Espejo, D; Pickard, JD; Laureys, S; Owen, AM (2013). "Reanalysis of "Bedside detection of awareness in the vegetative state: a cohort study" — Authors' reply". Lancet. 381 (9863): 291–292. doi:10.1016/s0140-6736(13)60126-9. PMID 23351803. S2CID 54327359.
  36. ↑ Owen, Adrian (20 June 2017). Into the Gray Zone. ISBN 9781501135200.
  37. ↑ Davies, Helen (27 August 2017). "Book review: Into the Grey Zone: A Neuroscientist Explores the Border Between Life and Death by Adrian Owen". The Times. ISSN 0140-0460. Retrieved 7 September 2019.
  38. ↑ Yorker, The New (6 July 2017). "What We're Reading This Summer". The New Yorker. ISSN 0028-792X. Retrieved 7 September 2019.
  39. ↑ Into the Gray Zone: A Neuroscientist Explores the Border Between Life and Death. Scribner. 20 June 2017 – via www.amazon.com.
  40. ↑ "Scientists by day, pop stars by night". Western Gazette. 22 September 2016.
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