| ADHFE1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | ADHFE1, ADH8, HOT, HMFT2263, alcohol dehydrogenase, iron containing 1, alcohol dehydrogenase iron containing 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 611083 MGI: 1923437 HomoloGene: 5865 GeneCards: ADHFE1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Alcohol dehydrogenase, iron containing 1 is a protein that in humans is encoded by the ADHFE1 gene.[5]
Function
The ADHFE1 gene encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues.[6]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000147576 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025911 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Entrez Gene: Alcohol dehydrogenase, iron containing 1". Retrieved 2017-06-16.
- ↑ Kardon T, Noël G, Vertommen D, Schaftingen EV (April 2006). "Identification of the gene encoding hydroxyacid-oxoacid transhydrogenase, an enzyme that metabolizes 4-hydroxybutyrate". FEBS Letters. 580 (9): 2347–50. doi:10.1016/j.febslet.2006.02.082. PMID 16616524. S2CID 46525441.
Further reading
- Deng Y, Wang Z, Gu S, Ji C, Ying K, Xie Y, Mao Y (October 2002). "Cloning and characterization of a novel human alcohol dehydrogenase gene (ADHFe1)". DNA Sequence. 13 (5): 301–6. doi:10.1080/1042517021000011636. PMID 12592711. S2CID 24529446.
- Lyon RC, Johnston SM, Panopoulos A, Alzeer S, McGarvie G, Ellis EM (March 2009). "Enzymes involved in the metabolism of gamma-hydroxybutyrate in SH-SY5Y cells: identification of an iron-dependent alcohol dehydrogenase ADHFe1". Chemico-Biological Interactions. 178 (1–3): 283–7. doi:10.1016/j.cbi.2008.10.025. PMID 19013439.
- Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ (September 2010). "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression". PLOS ONE. 5 (9): e12862. Bibcode:2010PLoSO...512862H. doi:10.1371/journal.pone.0012862. PMC 2943476. PMID 20877624.
- Tae CH, Ryu KJ, Kim SH, Kim HC, Chun HK, Min BH, Chang DK, Rhee PL, Kim JJ, Rhee JC, Kim YH (March 2013). "Alcohol dehydrogenase, iron containing, 1 promoter hypermethylation associated with colorectal cancer differentiation". BMC Cancer. 13: 142. doi:10.1186/1471-2407-13-142. PMC 3618294. PMID 23517143.
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