ADHFE1
Identifiers
AliasesADHFE1, ADH8, HOT, HMFT2263, alcohol dehydrogenase, iron containing 1, alcohol dehydrogenase iron containing 1
External IDsOMIM: 611083 MGI: 1923437 HomoloGene: 5865 GeneCards: ADHFE1
Orthologs
SpeciesHumanMouse
Entrez

137872

76187

Ensembl

ENSG00000147576

ENSMUSG00000025911

UniProt

Q8IWW8

Q8R0N6

RefSeq (mRNA)

NM_144650

NM_175236
NM_001357376
NM_001357377
NM_001357378

RefSeq (protein)

NP_653251

NP_780445
NP_001344305
NP_001344306
NP_001344307

Location (UCSC)Chr 8: 66.43 – 66.47 MbChr 1: 9.62 – 9.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Alcohol dehydrogenase, iron containing 1 is a protein that in humans is encoded by the ADHFE1 gene.[5]

Function

The ADHFE1 gene encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000147576 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025911 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Alcohol dehydrogenase, iron containing 1". Retrieved 2017-06-16.
  6. Kardon T, Noël G, Vertommen D, Schaftingen EV (April 2006). "Identification of the gene encoding hydroxyacid-oxoacid transhydrogenase, an enzyme that metabolizes 4-hydroxybutyrate". FEBS Letters. 580 (9): 2347–50. doi:10.1016/j.febslet.2006.02.082. PMID 16616524. S2CID 46525441.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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