Aldo Castellani, KCMG
Castellani in 1934
Born(1874-09-08)8 September 1874
Florence, Italy
Died3 October 1971(1971-10-03) (aged 97)
Lisbon, Portugal
NationalityItalian
Alma materUniversity of Florence
Known forCastellani’s paint
AwardsHonorary Knight Commander of the Order of St Michael and St George
Scientific career
Fieldsdermatology, bacteriology
InstitutionsBonn, London, Colombo, Naples, St Louis, Lisbon
Academic advisorsCelso Pellizzari (1851–1925)

Aldo Luigi Mario Castellani, Marchese di Chisimajo, KCMG (8 September 1874[1] – 3 October 1971) was an Italian pathologist and bacteriologist. He is best remembered as discoverer of the etiology of sleeping sickness (with David Bruce, 1903) and Yaws (1905), as a pioneer in the development and use of combined vaccines.

Life and achievements

Castellani was born in Florence and educated there, qualifying in medicine in 1899. He worked for a time in Bonn and joined the School of Hygiene and Tropical Medicine in London in 1901. As bacteriologist with the Royal Society Commission on Sleeping Sickness in 1902, he went to Entebbe, Uganda with George Carmichael Low and Cuthbert Christy. He demonstrated the cause and means of transmission of sleeping sickness, discovered the spirochete of yaws, and did other original work in bacteriology and in parasitic diseases of the skin. In 1903 he was appointed Bacteriologist to the Government of Ceylon at the Central laboratory in Colombo and continued research in mycology and bacteriology, describing several new species of intestinal bacilli.[2] He invented the absorption test for the serological identification of closely allied organisms. He left Ceylon in 1915 for Naples where he took the Chair of Medicine. He was involved during World War I in Serbia and Macedonia as a member of the Inter-Allied Sanitary Commission.

In 1919 Castellani went to London as Consultant to the Ministry of Pensions.[3] He became lecturer on mycology and mycotic diseases at the London School of Hygiene and Tropical Medicine,[4] and established a consulting practice in Harley Street. He was knighted in 1928 as an Honorary KCMG[5] and in 1934 his daughter Jacqueline Castellani married Sir Miles Lampson.

Castellani's enthusiasm for Royal and eminent patients such as Benito Mussolini clouded his reputation and during World War II he supported Italy against the Allies, becoming chief of the Italian Army's medical service. War correspondent Alaric Jacob discovered his looted quarters in Cirene in December 1941 and was tempted to pass his correspondence to his son in law Sir Miles Lampson, then British Ambassador in Egypt.[6]

Castellani was President of the International Society of Dermatology from 1960 to 1964,[7] which he had founded in 1959. He was also professor of tropical medicine at the State University of Louisiana and also at the Royal University of Rome. He followed the Queen of Italy Marie José into exile in Portugal and ended his life as Professor at Lisbon's Institute of Tropical Medicine. Castellani died in 1971.[3] Castellani's paint (Carbol fuchsin solution) is still occasionally used to treat fungal skin infections.[8]

The human pathogen Acanthamoeba castellanii is named after him.

Literary works

  • Manual of tropical medicine, 1910 (with Albert John Chalmers);[9] 2nd edition, 1913;[10] 3rd edition. 1919.
  • Fungi and fungous diseases, 1928[11][12]
  • Climate and acclimatisation, 1938[13]
  • Manuale di clinica tropicale, (with Jacono)
  • Microbes, Men and Monarchs: A Doctor's Life in Many Lands: The Autobiography of Aldo Castellani Victor Gollancz LTD (1963)

References

  1. ↑ The year of birth is also given as 1877 in some sources
  2. ↑ Medical Research Institute, Sri Lanka Archived 19 December 2014 at the Wayback Machine
  3. 1 2 CASTELLANI, Sir Aldo (1877–1971) Archived 16 July 2011 at the Wayback Machine. London School of Hygiene and Tropical Medicine
  4. ↑ "Sir Aldo Castellani". Nature. 130 (3291): 802. 1932. doi:10.1038/130802b0.
  5. ↑ His honours were withdrawn in the course of World War II, but later regranted by Queen Elizabeth II
  6. ↑ Jacob, Alaric (1944) A Traveller's War. Collins
  7. ↑ International Society of Dermatology
  8. ↑ Martindale, William; Blacow, Norman W. and Wade, Ainley (1972) The extra pharmacopoeia: incorporating Squire's "Companion." Pharmaceutical Press. ISBN 0853690782. p. 198
  9. ↑ "Review of Manual of tropical medicine, 1st edition". Interstate Medical Journal. 17: 805. 1910.
  10. ↑ "Review of Manual of tropical medicine, 2nd edition". The American Journal of Tropical Diseases and Preventive Medicine. 1 (1): 339.
  11. ↑ "Review of Fungi and Fungous Diseases". Archives of Internal Medicine. 43 (4): 569. 1929. doi:10.1001/archinte.1929.00130270143012.
  12. ↑ "Review of Fungi and Fungous Diseases". Nature. 125 (3156): 631. 1930. Bibcode:1930Natur.125..631G. doi:10.1038/125631a0. S2CID 186244342.
  13. ↑ "Review of Climate and Acclimatization: Some Notes and Observations". Nature. 131 (3316): 712. 1933. Bibcode:1933Natur.131V.712.. doi:10.1038/131712f0. S2CID 5903466.

Bibliography

  • Anonymous, “Aldo Castellani (Obituary)”, The British Medical Journal, 16 October 1971, p. 175
  • Binazzi, Maurizio, “Italian Memoirs of Aldo Castellani”, International Journal of Dermatology, vol. 30, n. 10 (October 1991), pp. 741-5
  • Borghi, Luca, Riva, Elisabetta, “Was Aldo Castellani the inventor of combined and polyvalent vaccines?”, Vaccine, 39 (2021), pp. 5442–5446
  • Borghi, Luca, “Man Who Won the War”: Myth and Reality of Aldo Castellani’s Role in Preserving the Health of Troops During the Italo-Ethiopian War 1935–1936, Adv Exp Med Biol, 2022 Jul 26. Online ahead of print. https://doi.org/10.1007/5584_2022_737
  • Bosco, G., “Ricordo di Aldo Castellani”, Rivista Italiana d’Igiene, vol. 62 (2003), nn. 1-2, pp. 1-17
  • Cambournac, Francisco J.C., “Professor Sir Aldo Castellani”, Anais da Escola Nacional de Saude Publica e de Medicina Tropical, vol. 5, nn. 3-4 (Julho-Dezembro 1971), pp. 377-383
  • Cipollaro, Vincent A., “Euphoria et cacophoria - anecdotes, reminiscences and controversies of Aldo Castellani; and ‘who let Castellani go’?”, International Journal of Dermatology, 2007, 46, 439–442
  • Cook, Gordon C., “Aldo Castellani FRCP (1877-1971) and the founding of the Ross Institute & Hospital for Tropical Diseases at Putney”, J Med Biog 2000: 8, 198-205
  • Garnham, Percy Cyril C., “Aldo Castellani 1877-1971”, Commentarii Pontificia Academia Scientiarum, vol. 2 (1972), n. 45, pp. 1-35
  • Ito, Kasuke, “A Synopsis of the Life of Aldo Castellani”, International Journal of Dermatology, vol. 11, n. 4 (oct-dec 1972), pp. 192-6
  • Parish, Lawrence Charles, “Reflections on Aldo Castellani and Tropical Dermatology”, Trans R Soc Trop Med Hyg, 2018 Apr 1;112(4):155-157
  • Raffaele, Giulio, Aldo Castellani. Discorso commemorativo pronunciato dal Linceo Giulio Raffaele nella Seduta ordinaria del 14 aprile 1973, Accademia Nazionale dei Lincei, Roma 1973, pp. 17
  • Rho, Filippo, “Glorie e figure della Medicina Italiana: Aldo Castellani”, Estratto da La Medicina Italiana (n. 7, luglio 1922), pp. 8
  • Sebastiani, Antonio, Serarcangeli, Carla, “Aldo Castellani (1874-1971). Un viaggio scientifico lungo un secolo”, Medicina nei Secoli, 2003;15(3):469-500
  • Seeliger, H.P.R., Seefried, L., “Aldo Castellani - an Appraisal of his Life and Oeuvre”, Mycoses, 15 May 1989, 32(8), pp. 391-397
  • Vanbreuseghem, Raymond, “Notice sur la vie et l’oeuvre du Professeur Aldo Castellani, Membre honoraire étranger (8 septembre 1874 – 3 octobre 1971)”, Bull. Acad. Mèd. Belg., 128 (1973), pp. 69-78
  • W.F.D.-C., “Aldo Castellani (Obituary)”, The Lancet, 16 October 1971, p. 883
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