Dr. Alvaro Morales, MD, FRCSC CC is a Colombian-Canadian urologist, surgeon and Member of the Order of Canada who is noted for his work in the fields of cancer research and testosterone deficiency.[1] He is particularly known for his pioneering work using Bacillus Calmette–Guérin (BCG) to treat bladder cancer,[2] the first proven immunotherapy for cancer.[3] A 2018 article in the Canadian Urological Association Journal said Morales' cancer research "changed the course of urology" and described him as a "living legend."[4]

BCG Immunotherapy

In the 1970s, while working in the Department of Urology at Queen's University in Kingston, Ontario, Canada, Morales developed a hypothesis considering the use of BCG, a live tuberculosis vaccine, to treat non muscle invasive urothelial bladder cancer (NMIBC).[5] His initial request for research funding from the National Cancer Institute of Canada was rejected with the note that "BCG is not only ineffective and dangerous but a throwback to the stone age of tumor immunology."[6][7]

Eventually developed with funding from the Cancer Research Institute of New York, the therapy involved introducing BCG to infect the bladder, provoking an immune system response sufficiently robust to eliminate some tumors without the use of chemicals.[8]

BCG immunotherapy was found to be effective in up to 2/3 of superficial tumors, and in randomized trials has been shown to be superior to standard chemotherapy.[9] In 1990, the treatment became the first therapy approved for use by the FDA against solid NMIBC tumors[10][11] and remains the "gold standard" treatment more than 40 years later.[12] In 2018, BCG was described in the Canadian Urological Association Journal as "the most effective, and longest continually used immunotherapy for any cancer."[13]

Morales' research on the treatment, published in 1976, has been described as "the seminal paper on the use of intravesical BCG in human patients"[14] and was hailed by the Journal of Urology as one of the most important papers on bladder cancer research in the past 100 years.[15]

Medical and Academic Career

Morales joined the Department of Urology at Queen's University in 1973 and served as head of the department from 1982 until his resignation in 1997. He retired from Queen's University in 2004 and founded the university's Centre for Applied Urological Research in 2005. He retired from the medical profession in 2011.[16]

Awards and recognition

Boards and societies

Morales is a member of numerous international medical boards and societies; he is the former president of both the Canadian Urological Association and the Northeastern Section of the American Urological Association. Additionally, he is a member of the Royal College of Physicians and Surgeons of Canada, the American College of Surgeons, American Urological Association and British Urological Association.

He is also an honorary member of the U.S. National Academy of Medicine, the Colombian Urological Association and Mexican Urological Society.[17]

Awards

Over the course of his career, Morales has received numerous awards for his medical research and contributions to the fields of oncology and andrology.[18] These have included:

In 2011, Morales was made a Member of the Order of Canada.[28]

References

  1. ↑ "Dr. Alvaro Morales, Member of the Order of Canada".
  2. ↑ "A Brief History of Urology at Queen's University".
  3. ↑ "Immunology of Bacille Calmette-Guérin and Related Topics, R. Wittes, Clin. Infectious Dis. 31:S59-S63, 2000". cid.oxfordjournals.org. Archived from the original on 19 September 2015. Retrieved 2016-04-15.
  4. ↑ Roehmholdt M, Lian F, Chang Kit L (September 2018). "Alvaro Morales: 40 years of Bacillus Calmette-Guérin, bladder cancer, and beyond". The Canadian Urological Association Journal. 12 (9S4): S236. doi:10.5489/cuaj.5656. PMC 6199961. PMID 30260770.
  5. ↑ "What Makes Immunotherapy for Bladder Cancer a Promising Treatment?".
  6. ↑ "Seminal Moments in Canadian Urology" (PDF).
  7. ↑ "What Makes Immunotherapy for Bladder Cancer a Promising Treatment?".
  8. ↑ "New made-in-Canada therapy for bladder cancer shows promising results". May 24, 2011.
  9. ↑ Lamm DL, Blumenstein BA, Crawford ED, Montie JE, Scardino P, Grossman HB, et al. (October 1991). "A randomized trial of intravesical doxorubicin and immunotherapy with bacille Calmette-Guérin for transitional-cell carcinoma of the bladder". The New England Journal of Medicine. 325 (17): 1205–9. doi:10.1056/NEJM199110243251703. PMID 1922207.
  10. ↑ Solinas C, Martinez Chanza N, Awada A, Scatozzi, M (December 2016). "The immune infiltrate in prostate, bladder and testicular tumors: An old friend for new challenges". Cancer Treatment Reviews. 53: 138–45. doi:10.1016/j.ctrv.2016.12.004. PMID 28113097.
  11. ↑ "What Makes Immunotherapy for Bladder Cancer a Promising Treatment?". May 24, 2011.
  12. ↑ Desouky E (July 2020). "Intravesical BCG amid COVID-19: To give or not to give?". Turkish Journal of Urology. 46 (4): 274–6. doi:10.5152/tud.2020.20206. PMC 7360161. PMID 35929882. S2CID 226715698.
  13. ↑ Roehmholdt M, Lian F, Chang Kit L (September 2018). "Alvaro Morales: 40 years of Bacillus Calmette-Guérin, bladder cancer, and beyond". The Canadian Urological Association Journal. 12 (9S4): S236. doi:10.5489/cuaj.5656. PMC 6199961. PMID 30260770.
  14. ↑ Fuge O, Vasdev N, Allchorne P, Green J (May 2015). "Immunotherapy for bladder cancer". Research and Reports in Urology. 2015 (7): 65–79. doi:10.2147/RRU.S63447. PMC 4427258. PMID 26000263.
  15. ↑ "Morales | Department of Urology | School of Medicine | Queen's University". urology.queensu.ca.
  16. ↑ "A Brief History of Urology at Queen's University".
  17. ↑ "Biography: Alvaro Morales; International Society for the Study of the Aging Male".
  18. ↑ "Biography: Alvaro Morales; International Society for the Study of the Aging Male".
  19. ↑ "Governor General of Canada; Awards".
  20. ↑ "AUA Award History".
  21. ↑ "Governor General of Canada; Awards".
  22. ↑ "SIU-Astellas European Foundation Award 2016" (PDF).
  23. ↑ "Seminal Moments in Canadian Urology" (PDF).
  24. ↑ "CUA Lifetime Achievement Award" (PDF).
  25. ↑ "William B. Coley Award".
  26. ↑ "AUA Distinguished Contribution Award".
  27. ↑ "Why Dornier".
  28. ↑ "Two Queen's Profs to Receive Order of Canada". July 7, 2011.


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