Creating Task Force X

Amanda Waller is introduced in Suicide Squad as an FBI official in charge of A.R.G.U.S.. She is shown to be in contact with vigilantes such as Bruce Wayne / Batman, to whom she provides intelligence in order for him to apprehend criminals such as Floyd Lawton / Deadshot. Following the death of Superman,^{[lower-alpha 1]} Waller, concerned that the "next Superman" may not "share his moral code," creates Task Force X, later known as the "Suicide Squad", by enlisting incarcerated metahumans and other extraordinary criminals such as Deadshot, Harley Quinn, Captain Boomerang, El Diablo, and Killer Croc. She also attempts to enlist June Moon / Enchantress and Slipknot, but Enchantress goes rogue and creates a global threat while Slipknot is executed for desertion by squad leader Rick Flag during the squad's mission to contain Enchantress. The squad is forced to rescue Waller, much to their chagrin, as she is attempting to cover up her role in Enchantress' escape.

After the team neutralizes Enchantress, freeing Moon from her possession, Waller rewards most of its members except Captain Boomerang with 10 years reduced from their sentences and various gifts. She later meets in-person with Bruce Wayne, giving him classified government documents on several metahumans including Arthur Curry and Barry Allen so he can recruit them for his own team,^{[lower-alpha 2]} in exchange for Wayne protecting her reputation and concealing her involvement with Task Force X.

Destroying Project Starfish

Waller deploys two Task Force X groups, each squad initially unaware of the existence of the other, in Corto Maltese following an anti-American coup to disrupt the country’s "Project Starfish", revealed to be a mission to conceal America’s role in the inhumane experiments. The first squad, led by Rick Flag and also including Harley Quinn, Captain Boomerang, and several others, attacks via amphibious warfare and save for Flag, Quinn, and teammates T.D.K. and Weasel, is annihilated by Corto Maltesean defenses, with Flag being rescued by the local rebellion group, the Freedom Fighters, Quinn being captured by the military and T.D.K. and Weasel being left for dead but still had survived. Waller personally executes a terrifying teammate Savant for desertion by remotely detonating an explosive planted in his head. The second squad, consisting of Robert DuBois / Bloodsport, whom Waller personally blackmails into joining and leading the second team by threatening to incarcerate his daughter Tyla into Belle Reve, Chris Smith / Peacemaker, Nanaue / King Shark, Cleo Cazo / Ratcatcher 2 and her pet rat Sebastian, and Abner Krill / Polka-Dot Man, infiltrates while the Corto Maltesean military is distracted by the first squad, which was merely a deliberate decoy.

The second squad rescues Flag and Quinn before converging on the location of Project Starfish at Jötunheim, a Nazi-era research facility. Both revealed by their captive, the project's head geneticist, Thinker, who was forced by the team to help them infiltrated Jötenheim, that he had been hired by both the United States and Corto Maltesean governments to oversee the project and Waller's real attention to assembled this squad. Waller has also specifically planted Peacemaker to ensure no one leaked the project. The ensuing scuffle results in Peacemaker remorsefully killing Flag and almost killing Cazo before Bloodsport subdues him, in addition to Starro, the giant, starfish-like alien at the center of "Project Starfish", breaking out, kills Thinker for the experiments on it, wreaking havoc on the island and taking control of its inhabitants. Waller orders the remaining squad members to evacuate, but they defy her orders, out of concern for Corto Maltese's citizens. Enraged, Waller threatens to execute them all before her subordinate Flo Crawley knocks her out and, along with the tactical support team, including Emilia Harcourt and John Economos, give the squad the go-ahead to save Corto Maltese from Starro. After they kill the giant alien, Bloodsport is able to negotiate with a recovering Waller to let him and his remaining squad teammates Quinn, Nanaue, Cazo and Sebastian go free and airlifted them off the island along to still drop his daughter's incarcerate, using the evidence he took of the American involvement in Project Starfish as a bargaining chip.

Project Butterfly

Several months after Project Starfish, Waller commissions a new team to contain an extraterrestrial threat, an alien race called the Butterflies, with Clemson Murn assigned to lead and Peacemaker assigned after his recovery, unknown to her that Murn is killed and controlled by a rogue Butterfly named Ik Nobe Lok. As punishment for their insubordination during Project Starfish, Economos and Harcourt are also assigned by Waller, much to their chagrin as they feel as if they are being forced to "babysit" Smith. Waller's daughter Leota Adebayo, also assigned to the team, is conflicted between following her mother's orders to incriminate Smith and her bond with him. She asks her mother for aid when Smith's team finds the "cow" of the Butterflies, after which Waller summons the Justice League, albeit too late. Leota, becoming disillusioned with her mother, later leaks Waller's involvement with both Project Butterfly and Task Force X, clearing Smith's name and putting a shocking Waller in a predicament in the process.

Release of Teth-Adam

After Teth-Adam is awakened from a 5,000-year slumber in Kahndaq, Waller contacts Carter Hall / Hawkman and the Justice Society, dispatching them to contain Adam and prevent him from potentially unleashing another rampage for which he was imprisoned by the Council of Wizards. After coming to terms with Adam and facing off against Intergang, the Justice Society take in Adam, who surrenders out of remorse and feeling unfit to be a hero. However, Adam is broken out of his containment by Kent Nelson / Doctor Fate and helps save the country from Sabbac. Waller contacts Adam, who has now adapted the more modern name Black Adam, warning him not to leave Khandaq and sending a since-resurrected Superman^{[lower-alpha 2]} to have a word with him.

Forming the Creature Commandoes

In the continuity set after the events of The Flash, this intergation of Waller assembles a black ops team of monsters led by Rick Flag Sr. and consisting of Nina Mazursky, Doctor Phosphorus, Eric Frankenstein, the Bride of Frankenstein, G.I. Robot, and Weasel.