Amylyx Pharmaceuticals
TypePublic
Nasdaq: AMLX
ISINUS03237H1014
IndustryPharmaceuticals
Founded2013 (2013)
Founder
  • Joshua Cohen
  • Justin Klee
HeadquartersCambridge, Massachusetts
Key people
  • Joshua Cohen (co-CEO)
  • Justin Klee (co-CEO)
Websitehttps://www.amylyx.com/

Amylyx Pharmaceuticals, Inc is a biopharmaceutical company headquartered in Cambridge, Massachusetts. Amylyx is best known for AMX0035, an experimental therapy for amyotrophic lateral sclerosis. AMX0035 was approved for medical use in Canada as Albrioza, in June 2022,[1] and in the United States, as Relyvrio, in September 2022.[2]

History

Amylyx Pharmaceuticals was founded in 2013 by Joshua Cohen and Justin Klee when the two were undergraduate students at Brown University.[3][4] The two proposed that taurursodiol and sodium phenylbutyrate together might prevent dysfunction of mitochondria and the endoplasmic reticulum, safeguarding neurons.[4] Klee and Cohen were advised by Rudolph E. Tanzi, who ultimately served as the founding chair of Amylyx's scientific advisory board. After Klee and Cohen were able to achieve strong results in pre clinical research, Tanzi connected the two to his colleagues at Massachusetts General Hospital, which culminated in clinical trials.[5] The company was granted $2.2 million by the ALS Association with funds raised through the Ice Bucket Challenge.[6]

Amylyx went public in January 2022.[7] The company's shares began trading on the Nasdaq on January 7, 2022 under the symbol AMLX.

References

  1. ↑ "Amylyx Pharmaceuticals Announces Health Canada Approval of Albrioza for the Treatment of ALS" (Press release). Amylyx. 13 June 2022. Archived from the original on 14 June 2022. Retrieved 13 June 2022.
  2. ↑ "FDA Approves New Treatment Option for Patients with ALS". U.S. Food and Drug Administration (FDA) (Press release). 29 September 2022. Archived from the original on 29 September 2022. Retrieved 29 September 2022. Public Domain This article incorporates text from this source, which is in the public domain.
  3. ↑ James, Beth. "Biotech company Amylyx emerges from scientific curiosity of Brown undergrads". Engineering | Brown University. Retrieved 2022-11-15.
  4. 1 2 Belluck, Pam (2020-10-16). "Drug May Extend A.L.S. Patients' Lives by Several Months, Study Finds". The New York Times.
  5. ↑ Keshavan, Meghana (2020-09-02). "Experimental drug for ALS, dreamed up in a dorm room, offers patients glimmer of hope". STAT. Retrieved 2022-11-15.
  6. ↑ "A new ALS treatment has ties to the Ice Bucket Challenge. Here's how". www.boston.com. Retrieved 2022-11-15.
  7. ↑ Beltran, Luisa. "The Year's First Three IPOs All Struggled. This Is Why". www.barrons.com. Retrieved 2022-11-16.
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