Andreas Plückthun
Born (1956-05-07) May 7, 1956
Heidelberg, Germany
Known forAntibody engineering
AwardsSenior Investigator Grant of the European Research Council, Wilhelm-Exner Medal
Scientific career
FieldsBiochemistry
InstitutionsUniversity of Zurich

Andreas Plückthun (born May 7, 1956) is a scientist whose research is focused on the field of protein engineering. Andreas Plückthun is the director of the department of biochemistry at the University of Zurich.[1] Plückthun was appointed to the faculty of the University of Zurich as a Full professor of biochemistry in 1993. Plückthun was group leader at the Max Planck Institute of Biochemistry , Germany (1985-1993). He was elected to the European Molecular Biology Organization (EMBO) in 1992,[2] and named a member of the German National Academy of Science (Leopoldina) in 2003.[3] He is cofounder of the biotechnology companies Morphosys (Martinsried, Germany) Molecular Partners AG[4] (Zürich-Schlieren, Switzerland) and G7 Therapeutics.[5] (Zürich-Schlieren, Switzerland).[6]

Plückthun is a member of the board directors of the Antibody Society.

His work is highly cited in the field of antibody engineering. He has been honoured by a number of international awards.

Biography

Andreas Plückthun[7] was born in Heidelberg (Germany) and is married to Ilse Pfitzinger, together they have one daughter. He studied chemistry at the University of Heidelberg. He received his PhD degree at the University of California at San Diego with Edward Dennis,[8] the title of his dissertation being "The interfacial catalysis of phospholipase A2". He was a post-doctoral fellow at Harvard University with Jeremy Knowles, where he worked on the secretion process of beta-lactamase in Escherichia coli. In 1985, he became group leader at the Gene Center Munich, then located at the Max-Planck-Institute for Biochemistry in Martinsried (Germany). In 1993 he was appointed Full Professor of Biochemistry at the University of Zurich (Switzerland).[9]

Work

His research contributed to enabling the emergence of antibody engineering, notably by the use of E. coli as an engineering platform and studies on synthetic antibodies which led to the first fully synthetic antibody library. To create a true in vitro protein evolution technology his laboratory developed ribosome display of whole proteins. In his research group Designed Ankyrin Repeat Proteins (DARPins) were created as a robust alternative scaffold for binding proteins (antibody mimetics). DARPins are derived from naturally occurring ankyrin proteins, a protein class that mediates high-affinity protein-protein interactions in nature. DARPins (Designed Ankyrin Repeat Proteins), one of the most common binding proteins in nature and responsible for diverse functions, such as cell signaling and receptor binding. To obtain highly stable G protein-coupled receptors that can be used for structural studies and in drug screening, his research group developed new directed evolution technologies.

Honors and awards

He won a Young Investigator's Award of the German Chemical Industry Trust (Fonds der chemischen Industrie).[10] In 2000, he received the Karl-Heinz-Beckurts Award[11] (Munich, Germany). In 2002 he was given the J. P. Morgan Chase Health Award[12] (San Jose, CA, USA), the Wilhelm-Exner Medal[13] (Vienna, Austria) and The Jury's Grand Prix (European Grand Prix for Innovation, Monaco).[14] Together with the other founders of Molecular Partners AG, he received the Swiss Technology Award[15] and the De Vigier Award[16] in 2005. In 2011 he was awarded a Senior Investigator Grant of the European Research Council.[17] He is the recipient of the 2016 Christian B. Anfinsen Award.[18]

Appearances

In December 2018, Plückthun spoke at the 'Antibody Engineering and Therapeutics' conference in San Diego, California.[19]

References

  1. ↑ "UZH - Department of Biochemistry - Home". www.bioc.uzh.ch.
  2. ↑ "The EMBO Directory" (PDF). Archived from the original (PDF) on March 16, 2015.
  3. ↑ "List of Members". www.leopoldina.org.
  4. ↑ Molecular Partners
  5. ↑ G7 Therapeutics
  6. ↑ "MorphoSys hooks up with G7 Therapeutics to feed hunger for stabilized GPCRs". Fierce Biotech. 6 August 2015.
  7. ↑ "UZH - Department of Biochemistry - CV". www.bioc.uzh.ch.
  8. ↑ "Our Alumni". Archived from the original on 13 February 2008. Retrieved 21 March 2016.
  9. ↑ "Plueckthun Lab - Andreas Plückthun". www.bioc.uzh.ch.
  10. ↑ "- Verband der Chemischen Industrie e.V. (VCI)" (PDF). www.vci.de.
  11. ↑ "Preisträger - Karl Heinz Beckurts-Stiftung". www.beckurts-stiftung.de.
  12. ↑ "Past Laureates". The Tech Interactive. September 1, 2015. Archived from the original on February 3, 2021. Retrieved May 31, 2019.
  13. ↑ "Wilhelm Exner Medal Winners". Archived from the original on 2014-01-03. Retrieved 2016-01-25.
  14. ↑ "EUROPEAN GRAND PRIX FOR INNOVATION AWARDS". www.european-grandprix.com.
  15. ↑ "Founders of Molecular Partners receive the Swiss Technology Award" (PDF).
  16. ↑ "Founders of Molecular Partners receive the de Vigier Award". Archived from the original on 2016-03-12. Retrieved 2016-01-25.
  17. ↑ "EU-Gelder für Protein- und Hirnforschung". www.news.uzh.ch. 14 December 2010.
  18. ↑ "Christian B Anfinsen Award". Archived from the original on March 19, 2016.
  19. ↑ "Antibody Engineering and Therapeutics 2018 speaker line up".
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