Angiomotin-like protein 1

AMOTL1
Identifiers
Aliases	AMOTL1, JEAP, angiomotin like 1
External IDs	OMIM: 614657 MGI: 1922973 HomoloGene: 43977 GeneCards: AMOTL1
Gene location (Human)
Chr.	Chromosome 11 (human)
End	94,876,748 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	14,556,352 bp
RNA expression pattern
	Top expressed in
	tibialis anterior muscle; ; deltoid muscle; ; body of tongue; ; tibia; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; urethra; ; gastrocnemius muscle; ; secondary oocyte; ; saphenous vein;
	Top expressed in
	hand; ; knee joint; ; foot; ; soleus muscle; ; temporal muscle; ; lateral geniculate nucleus; ; triceps brachii muscle; ; sternocleidomastoid muscle; ; quadriceps femoris muscle; ; extraocular muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; identical protein binding;
Cellular component	COP9 signalosome; cytosol; apical plasma membrane; cytoplasmic vesicle; lamellipodium; bicellular tight junction; cell junction;
Biological process	establishment of cell polarity involved in ameboidal cell migration; Wnt signaling pathway; hippo signaling; positive regulation of blood vessel endothelial cell migration; actin cytoskeleton organization; regulation of cell migration; angiogenesis;
	Sources:Amigo / QuickGO
Orthologs
	154810
	75723
	ENSG00000166025
	ENSMUSG00000013076
	Q8IY63
	Q9D4H4
	NM_001301007; NM_130847
	NM_001081395
	NP_001287936; NP_570899; NP_570899.1
	NP_001074864
	Wikidata
View/Edit Human	View/Edit Mouse

Angiomotin-like protein 1 is a protein that in humans is encoded by the AMOTL1 gene.^[5]^[6]

Function

The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation.^[6]

1 2 3 GRCh38: Ensembl release 89: ENSG00000166025 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000013076 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nishimura M, Kakizaki M, Ono Y, Morimoto K, Takeuchi M, Inoue Y, Imai T, Takai Y (Feb 2002). "JEAP, a novel component of tight junctions in exocrine cells". J Biol Chem. 277 (7): 5583–7. doi:10.1074/jbc.M110154200. PMID 11733531.
1 2 "Entrez Gene: AMOTL1 angiomotin like 1".

Human AMOTL1 genome location and AMOTL1 gene details page in the UCSC Genome Browser.

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Bratt A, Wilson WJ, Troyanovsky B, et al. (2003). "Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains". Gene. 298 (1): 69–77. doi:10.1016/S0378-1119(02)00928-9. PMID 12406577.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Patrie KM (2005). "Identification and characterization of a novel tight junction-associated family of proteins that interacts with a WW domain of MAGI-1". Biochim. Biophys. Acta. 1745 (1): 131–44. doi:10.1016/j.bbamcr.2005.05.011. PMID 16019084.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

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