Anita Corbett
Born
Anita Hargrave Corbett
Alma materColgate University (BS)
Vanderbilt University (PhD)
Scientific career
FieldsmRNA processing
Polyadenylation
Gene expression
Intellectual disability[1]
InstitutionsEmory University
ThesisRegulation of the catalytic cycle of topoisomerase II (1992)
Doctoral advisorNeil Osheroff
Websitebiology.emory.edu/corbett

Anita Hargrave Corbett is an American biochemist who is the Samuel C. Dobbs Professor in the Department of Biology at Emory University.[1][2] Her research investigates the molecular basis for disease, the regulation of protein import and mRNA export. She is a Fellow of the American Association for the Advancement of Science and the American Society for Biochemistry and Molecular Biology.

Early life and education

As a high school student, Corbett took part in the National Science Bowl. She has said that her high school chemistry teacher made her believe she could be a chemist, and encouraged her to take AP Chemistry. She was an undergraduate student at Colgate University,[3] where she became interested in biochemistry, and studied the activation and inhibition of bovine carbonic anhydrase.[4] Corbett was a doctoral researcher at Vanderbilt University,[5] where she studied the regulation of topoisomerase II supervised by Neil Osheroff.[6]

Research and career

After her PhD, she moved to Harvard Medical School as a postdoctoral researcher with Pamela Silver.[7]

In 2003, Corbett was the first woman to be tenured in the Emory University School of Medicine.[5] Her research investigates the regulation of biological processes, including the import of proteins and export of mRNA. She studies these processes using model systems of yeast, Drosophila and laboratory mice.[8][9] It is well understood that disease is linked to mutations in genes encoding structural RNA exosome subunits.[5] Corbett linked mutations in one particular subunit, EXOSC5, to poor clinical outcomes.[10] She has extensively investigated RNA-binding proteins, which are involved with various stages of gene expression.[11]

Awards and honors

Selected publications

  • Allison Lange; Ryan E. Mills; Christopher J Lange; Murray Stewart; Scott E Devine; Anita H Corbett (14 December 2006). "Classical nuclear localization signals: definition, function, and interaction with importin alpha". Journal of Biological Chemistry. 282 (8): 5101–5105. doi:10.1074/JBC.R600026200. ISSN 0021-9258. PMC 4502416. PMID 17170104. Wikidata Q34591163.
  • Debashish Ray; Hilal Kazan; Kate B Cook; et al. (1 July 2013). "A compendium of RNA-binding motifs for decoding gene regulation". Nature. 499 (7457): 172–177. doi:10.1038/NATURE12311. ISSN 1476-4687. PMC 3929597. PMID 23846655. Wikidata Q34357005.
  • David S Goldfarb; Anita H Corbett; D Adam Mason; Michelle T Harreman; Stephen A. Adam (1 September 2004). "Importin alpha: a multipurpose nuclear-transport receptor". Trends in Cell Biology (in English and English). 14 (9): 505–514. doi:10.1016/J.TCB.2004.07.016. ISSN 0962-8924. PMID 15350979. Wikidata Q35879618.

References

  1. 1 2 Anita Corbett publications indexed by Google Scholar
  2. ↑ Anita Corbett publications from Europe PubMed Central
  3. ↑ "Anita H. Corbett, PhD". biology.emory.edu. Retrieved 2023-05-02.
  4. ↑ Rowlett, R S; Gargiulo, N J; Santoli, F A; Jackson, J M; Corbett, A H (1991-01-15). "Activation and inhibition of bovine carbonic anhydrase III by dianions". Journal of Biological Chemistry. 266 (2): 933–941. doi:10.1016/S0021-9258(17)35263-8. ISSN 0021-9258.
  5. 1 2 3 4 "Corbett goes the extra mile to support young scientists". asbmb.org. Retrieved 2023-05-02.
  6. ↑ Corbett, Anita Hargrave (1992). Regulation of the catalytic cycle of topoisomerase II (PhD thesis). OCLC 30332920. ProQuest 303996778.
  7. 1 2 Anon (2019). "Nature Awards give mentors the recognition, funding, and 'street cred' they need". springernature.com. Retrieved 2023-05-02.
  8. ↑ "Professor Anita H. Corbett". rnasociety.org. Retrieved 2023-05-02.
  9. ↑ Corbett, Anita H. (2015-04-01). "A long and winding road to the RNA world". RNA. 21 (4): 590–591. doi:10.1261/rna.049841.115. ISSN 1355-8382. PMC 4371294. PMID 25780152.
  10. ↑ Slavotinek, Anne; Misceo, Doriana; Htun, Stephanie; Mathisen, Linda; Frengen, Eirik; Foreman, Michelle; Hurtig, Jennifer E.; Enyenihi, Liz; Sterrett, Maria C.; Leung, Sara W.; Schneidman-Duhovny, Dina; Estrada-Veras, Juvianee; Duncan, Jacque L.; Haaxma, Charlotte A.; Kamsteeg, Erik-Jan (2020-08-03). "Biallelic variants in the RNA exosome gene EXOSC5 are associated with developmental delays, short stature, cerebellar hypoplasia and motor weakness". Human Molecular Genetics. 29 (13): 2218–2239. doi:10.1093/hmg/ddaa108. ISSN 1460-2083. PMC 7399534. PMID 32504085.
  11. ↑ "Anita Corbett". biology.emory.edu. Retrieved 2023-05-02.
  12. ↑ "Laney Graduate School announces Eleanor Main Graduate Mentor Awards | Emory University | Atlanta GA". news.emory.edu. Retrieved 2023-05-02.
  13. ↑ "Emory faculty named 2022 fellows of the American Association for the Advancement of Science | Emory University | Atlanta GA". news.emory.edu. Retrieved 2023-05-02.
  14. ↑ "2022 ASBMB fellows named". asbmb.org. Retrieved 2023-05-02.
  15. ↑ "2022 RNA Society Award for Excellence in Inclusive Leadership". rnasociety.org. Retrieved 2023-05-02.
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