Anna Huttenlocher
Parent(s)Peter Huttenlocher (father)
Janellen Huttenlocher (mother)
Academic background
EducationBA, Oberlin College
MD, Harvard Medical School
Academic work
InstitutionsUniversity of Wisconsin–Madison
Websitemmi.wisc.edu/staff/huttenlocher-anna/

Anna Huttenlocher is an American cell biologist and physician-scientist known for her work in cell migration and wound healing.

Early life and education

Huttenlocher was born to two academic parents; her father, Peter, was a pediatric neurologist and her mother, Janellen, was a psychologist.[1] She completed her Bachelor of Science degree at Oberlin College and her medical degree from Harvard Medical School.[2] Following Harvard, she completed her training at Boston Children's Hospital and the University of California, San Francisco.[3]

Career

Huttenlocher joined the faculty at the University of Wisconsin–Madison (UW-M) in 1999 with a joint appointment in the Departments of Pediatrics and Pharmacology, and as an associate director of the Medical Scientist Training Program (MSTP).[3] In this role, Huttenlocher's research has defined cellular and molecular mechanisms that regulate cell migration and identified basic adhesive mechanisms that regulate cell migration and leukocyte chemotaxis. By 2005, her research team had identified a novel pathway that turned out to be critical for cell migration and chemotaxis, involving intracellular proteolysis by the calcium-dependent protease calpain.[4][5] Her laboratory was also the first to document reverse migration of neutrophils away from sites of injury or inflammation.[6][7] In 2011 her group reported the first redox sensor that mediates leukocyte attraction to wounds.[8] In 2005 she was elected a member of the American Society for Clinical Investigation.[9] Huttenlocher was promoted to Professor with tenure in 2008[10] and was the recipient of the Graduate School’s H.I. Romnes Fellowship award.[11] She also received the Burroughs-Wellcome Fund’s Clinical Scientist Award in Translational Research for her project "Diagnosis and Treatment of Autoinflammatory Disease."[12] Huttenlocher was the recipient of a 2011 WARF Kellett Mid-Career Award.[13] Until 2023 she conducted this work while maintaining an active clinical practice as a pediatric rheumatologist.

In 2012, Huttenlocher was appointed as Director of the UW-Madison MD-PhD training program (MSTP), succeeding Deane Mosher.[3] She was active in that role for over ten years. During that time she was also elected into the Association of American Physicians.[14] In 2015 Dr. Huttenlocher was inducted as a Member of the National Academy of Medicine "for her pioneering studies of cell migration and alterations of cell migration in human diseases."[15] In 2017, Huttenlocher was awarded a UW2020 grant to support her project "Engineering leukocytes generated from human iPS cells to treat human disease."[16] At the same time, she was also elected a Fellow of the American Society for Cell Biology.[17]

In May 2020, Huttenlocher was named the Anna Ruth Brummett Professor of Pediatrics and Medical Microbiology and Immunology Chair in honor of her "major contributions to the advancement of knowledge."[18] The following year, she was part of a large team of researchers from the University of Wisconsin Carbone Cancer Center recognized with the Society for the Immunotherapy of Cancer’s Team Science Award for "long-standing contribution to the field of cancer immunotherapy over the past 35 years."[19] Huttenlocher's recent research projects include "Cell migration and wound repair"[20] and "Imaging immunometabolism in live animals during host defense."[21]

In 2023, Huttenlocher published the book "From Loss to Memory: Behind the Discovery of Synaptic Pruning".[22] It describes the discovery of synaptic pruning and its current relevance to early learning, autism, schizophrenia and Alzheimer's disease. The book centers on the intriguing life story of the discoverer of synaptic pruning, her father Peter Huttenlocher, and also discusses the physician-scientist career path.

References

  1. ↑ Easton, John (August 19, 2013). "Peter Huttenlocher, pediatric neurologist, 1931-2013". University of Chicago. Retrieved October 1, 2021.
  2. ↑ "Professor Anna Huttenlocher". Clare Hall, Cambridge. Retrieved October 1, 2021.
  3. 1 2 3 "Anna Huttenlocher". University of Wisconsin–Madison. Retrieved October 1, 2021.
  4. ↑ Lokuta, M. A., Nuzzi, P. A., & Huttenlocher, A. (2003). Calpain regulates neutrophil chemotaxis. Proceedings of the National Academy of Sciences of the United States of America, 100(7), 4006–4011. https://doi.org/10.1073/pnas.0636533100
  5. ↑ Franco, S. J., Rodgers, M. A., Perrin, B. J., Han, J., Bennin, D. A., Critchley, D. R., & Huttenlocher, A. (2004). Calpain-mediated proteolysis of talin regulates adhesion dynamics. Nature cell biology, 6(10), 977–983. https://doi.org/10.1038/ncb1175
  6. ↑ Mathias, J. R., Perrin, B. J., Liu, T. X., Kanki, J., Look, A. T., & Huttenlocher, A. (2006). Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish. Journal of Leukocyte Biology, 80(6), 1281–1288. https://doi.org/10.1189/jlb.0506346
  7. ↑ de Oliveira, S., Rosowski, E. & Huttenlocher, A. Neutrophil migration in infection and wound repair: going forward in reverse. Nat Rev Immunol 16, 378–391 (2016). https://doi.org/10.1038/nri.2016.49
  8. ↑ Yoo, S. K., Starnes, T. W., Deng, Q., & Huttenlocher, A. (2011). Lyn is a redox sensor that mediates leukocyte wound attraction in vivo. Nature, 480(7375), 109–112. https://doi.org/10.1038/nature10632
  9. ↑ "Anna Huttenlocher, MD". American Society for Clinical Investigation. Retrieved October 1, 2021.
  10. ↑ "FACULTY PROMOTIONS AS OF MARCH 3, 2008". University of Wisconsin–Madison. May 1, 2008. Retrieved October 1, 2021.
  11. ↑ "DR. ANNA HUTTENLOCHER AWARDED GRADUATE SCHOOL'S H.I. ROMNES FELLOWSHIP AWARD". University of Wisconsin–Madison. May 1, 2008. Retrieved October 1, 2021.
  12. ↑ "ANNA HUTTENLOCHER, MD, RECEIVES THE BURROUGHS-WELLCOME FUND'S CLINICAL SCIENTIST AWARD". University of Wisconsin–Madison. May 1, 2008. Retrieved October 1, 2021.
  13. ↑ "DR. ANNA HUTTENLOCHER, MD, EARNS WARF KELLETT MID-CAREER AWARD". University of Wisconsin–Madison. January 1, 2011. Retrieved October 1, 2021.
  14. ↑ "ANNA HUTTENLOCHER, MD, ELECTED TO THE ASSOCIATION OF AMERICAN PHYSICIANS". University of Wisconsin–Madison. February 1, 2012. Retrieved October 1, 2021.
  15. ↑ "ANNA HUTTENLOCHER, MD, ELECTED TO NATIONAL ACADEMY OF MEDICINE". University of Wisconsin-Madison. October 1, 2015. Retrieved October 1, 2021.
  16. ↑ "ANNA HUTTENLOCHER, MD, AWARDED A UW2020 GRANT". University of Wisconsin-Madison. June 1, 2017. Retrieved October 1, 2021.
  17. ↑ "DR. ANNA HUTTENLOCHER ELECTED AS AN AMERICAN SOCIETY FOR CELL BIOLOGY FELLOW". University of Wisconsin–Madison. October 1, 2017. Retrieved October 1, 2021.
  18. ↑ "DR. HUTTENLOCHER RECEIVES WARF NAMED PROFESSORSHIP". University of Wisconsin–Madison. May 13, 2020. Retrieved October 1, 2021.
  19. ↑ "PEDIATRIC 'DREAM TEAM' MEMBERS AND OTHERS RECOGNIZED WITH SITC'S TEAM SCIENCE AWARD". University of Wisconsin–Madison. January 10, 2021. Retrieved October 1, 2021.
  20. ↑ "ANNA HUTTENLOCHER RECEIVES $3.3M NIH AWARD TO FURTHER CELL MIGRATION RESEARCH". University of Wisconsin–Madison. June 29, 2021. Retrieved October 1, 2021.
  21. ↑ "DR. ANNA HUTTENLOCHER AWARDED TWO-YEAR NIH-NIAID GRANT". University of Wisconsin–Madison. March 24, 2021. Retrieved October 1, 2021.
  22. ↑ Huttenlocher, Anna (2023). From Loss to Memory: Behind the Discovery of Synaptic Pruning. Cambridge, UK: Cambridge University Press. ISBN 9781009267052.
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