Autophagy-related protein 13

ATG13
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5C50
Identifiers
Aliases	ATG13, KIAA0652, PARATARG8, autophagy related 13
External IDs	OMIM: 615088 MGI: 1196429 HomoloGene: 32229 GeneCards: ATG13
Gene location (Human)
Chr.	Chromosome 11 (human)
End	46,674,818 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	91,540,921 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; prefrontal cortex; ; tibial nerve; ; body of pancreas; ; stromal cell of endometrium; ; gallbladder; ; Brodmann area 9; ; gastric mucosa; ; cingulate gyrus; ; skin of abdomen;
	Top expressed in
	superior frontal gyrus; ; lip; ; cerebellar cortex; ; blastocyst; ; esophagus; ; lacrimal gland; ; islet of Langerhans; ; interventricular septum; ; soleus muscle; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; protein kinase binding;
Cellular component	cytoplasm; cytosol; Atg1/ULK1 kinase complex; mitochondrion; phagophore assembly site; endoplasmic reticulum membrane;
Biological process	autophagy; macroautophagy; autophagosome assembly; positive regulation of protein targeting to mitochondrion; mitophagy; response to mitochondrial depolarisation; regulation of macroautophagy;
	Sources:Amigo / QuickGO
Orthologs
	9776
	51897
	ENSG00000175224
	ENSMUSG00000027244
	O75143
	Q91YI1
NM_001142673; NM_001205119; NM_001205120; NM_001205121; NM_001205122;
	NM_001346311; NM_001346312; NM_001346313; NM_001346314; NM_001346315; NM_001346316; NM_001346317; NM_001346318; NM_001346319; NM_001346320; NM_001346321; NM_001346322; NM_001346323; NM_001346324; NM_001346325; NM_001346326; NM_001346327; NM_001346328; NM_001346329; NM_001346330; NM_001346331; NM_001346332; NM_001346333; NM_001346334; NM_001346335; NM_001346336; NM_001346337; NM_001346338; NM_001346340; NM_001346342; NM_001346344; NM_001346346; NM_001346348; NM_001346349; NM_001346350; NM_001346351; NM_001346352; NM_001346353; NM_001346354; NM_001346355; NM_001346356; NM_001346357; NM_001346358; NM_001346359; NM_001346360; NM_014741
NM_145528; NM_001355416; NM_001355417; NM_001355418; NM_001355419;
	NM_001355420; NM_001355421
NP_001136145; NP_001192048; NP_001192049; NP_001192050; NP_001192051;
	NP_001333240; NP_001333241; NP_001333242; NP_001333243; NP_001333244; NP_001333245; NP_001333246; NP_001333247; NP_001333248; NP_001333249; NP_001333250; NP_001333251; NP_001333252; NP_001333253; NP_001333254; NP_001333255; NP_001333256; NP_001333257; NP_001333258; NP_001333259; NP_001333260; NP_001333261; NP_001333262; NP_001333263; NP_001333264; NP_001333265; NP_001333266; NP_001333267; NP_001333269; NP_001333271; NP_001333273; NP_001333275; NP_001333277; NP_001333278; NP_001333279; NP_001333280; NP_001333281; NP_001333282; NP_001333283; NP_001333284; NP_001333285; NP_001333286; NP_001333287; NP_001333288; NP_001333289; NP_055556
NP_663503; NP_001342345; NP_001342346; NP_001342347; NP_001342348;
	NP_001342349; NP_001342350
	Wikidata
View/Edit Human	View/Edit Mouse

Autophagy-related protein 13 also known as ATG13 is a protein that in humans is encoded by the KIAA0652 gene.^[5]

ATG13 is an autophagy factor required for phagosome formation. ATG13 is a target of the TOR kinase signaling pathway that regulates autophagy through phosphorylation of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex.^[6]^[7]^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000175224 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027244 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: KIAA0652".
↑ Mercer CA, Kaliappan A, Dennis PB (July 2009). "A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy". Autophagy. 5 (5): 649–62. doi:10.4161/auto.5.5.8249. PMID 19287211.
↑ Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y, Iemura S, Natsume T, Takehana K, Yamada N, Guan JL, Oshiro N, Mizushima N (April 2009). "Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy". Mol. Biol. Cell. 20 (7): 1981–91. doi:10.1091/mbc.E08-12-1248. PMC 2663915. PMID 19211835.
↑ Chan EY, Longatti A, McKnight NC, Tooze SA (January 2009). "Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism". Mol. Cell. Biol. 29 (1): 157–71. doi:10.1128/MCB.01082-08. PMC 2612494. PMID 18936157.

External links

Human ATG13 genome location and ATG13 gene details page in the UCSC Genome Browser.

Hosokawa N, Sasaki T, Iemura S, et al. (2009). "Atg101, a novel mammalian autophagy protein interacting with Atg13". Autophagy. 5 (7): 973–9. doi:10.4161/auto.5.7.9296. PMID 19597335.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Chan EY (2009). "mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex". Science Signaling. 2 (84): pe51. doi:10.1126/scisignal.284pe51. PMID 19690328. S2CID 206673207.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Jung CH, Jun CB, Ro SH, et al. (2009). "ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery". Mol. Biol. Cell. 20 (7): 1992–2003. doi:10.1091/mbc.E08-12-1249. PMC 2663920. PMID 19225151.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
Chan EY, Longatti A, McKnight NC, Tooze SA (2009). "Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism". Mol. Cell. Biol. 29 (1): 157–71. doi:10.1128/MCB.01082-08. PMC 2612494. PMID 18936157.
Ganley IG, Lam du H, Wang J, et al. (2009). "ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy". J. Biol. Chem. 284 (18): 12297–305. doi:10.1074/jbc.M900573200. PMC 2673298. PMID 19258318.
Sinzelle L, Kapitonov VV, Grzela DP, et al. (2008). "Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes". Proc. Natl. Acad. Sci. U.S.A. 105 (12): 4715–20. doi:10.1073/pnas.0707746105. PMC 2290759. PMID 18339812.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000175224 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027244 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: KIAA0652".

[pmid19287211-6] Mercer CA, Kaliappan A, Dennis PB (July 2009). "A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy". Autophagy. 5 (5): 649–62. doi:10.4161/auto.5.5.8249. PMID 19287211.

[pmid19211835-7] Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y, Iemura S, Natsume T, Takehana K, Yamada N, Guan JL, Oshiro N, Mizushima N (April 2009). "Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy". Mol. Biol. Cell. 20 (7): 1981–91. doi:10.1091/mbc.E08-12-1248. PMC 2663915. PMID 19211835.

[pmid18936157-8] Chan EY, Longatti A, McKnight NC, Tooze SA (January 2009). "Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism". Mol. Cell. Biol. 29 (1): 157–71. doi:10.1128/MCB.01082-08. PMC 2612494. PMID 18936157.

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References

External links

Further reading