Avery August
Born (1964-01-28) 28 January 1964
Belize City, Belize
Alma mater
Scientific career
Fields
Institutions

Avery August (born January 28, 1964) is a Belizean-born American scientist who is currently a professor of immunology and vice provost at Cornell University.

Education

Avery August was born in Belize City, Belize. August attended government primary schools, and subsequently attended St. Michael's College for Boys (as High Schools in Belize are called),[1] where he earned a High School Diploma. Following one year at the Belize Technical College, he emigrated with his family to Los Angeles, California. There he attended California State University, Los Angeles,[2] where he earned a B.S. degree in Medical Technology.[3] While at California State University, he got involved in undergraduate research in the laboratory of Phoebe Dea, then Professor of Chemistry & Biochemistry at California State University[4] (see Scientific Career below for details). This first exposure to research pushed him to attend graduate school at Cornell University's Weill Graduate School of Medical Sciences in New York City. There he worked at the Sloan Kettering Institute (an institute within the Memorial Sloan Kettering Cancer Center) with Immunologist Bo Dupont, and where he earned his PhD in immunology. He then gained post-doctoral experience at The Rockefeller University, working with renowned virologist and National Academy of Science member, Hidesaburo Hanafusa.

Scientific career

August first worked in the catalytic synthesis of fatty acids and other lipids as an undergraduate student in Prof. Dea's laboratory at California State University, Los Angeles. This work resulted in the publication on methods to easily catalyze the insertion of deuterium into unsaturated fatty acids, which could then be used as probes of membrane structure.[5] Then, he became interested in immunology as he described in a recent interview with Stephanie Houston of Journal of Experimental Medicine.[6]

Upon moving to Cornell University, August initiated work on his PhD thesis, to understand the molecular basis of activation of T cells. T cells are major players in regulating the development of an immune response.[7] The importance of these cells is illustrated by the fact that the virus HIV infects helper T cells, and thus disables effective immunity against the virus, resulting in Acquired Immune Deficiency Syndrome or AIDS.[8]

August joined the laboratory of Bo Dupont at the Sloan-Kettering Research Institute for Cancer Research and worked on unraveling the molecular basis for T cell co-stimulation by the cell surface protein CD28. This work resulted in 9 publications (see references at PubMed). This work also led to the production of his PhD thesis entitled "On the molecular basis of the two signal hypothesis of T cell activation: Signaling by CD3 and CD28" from Weill Cornell Graduate School of Medical Sciences of Cornell University.[9]

Following graduation, August joined the Laboratory of Molecular Oncology at Rockefeller University, headed by Hidesaburo Hanafusa. At The Rockefeller, August worked on a number of areas, including analysis of the BRCA1 oncogene that when mutated, results in much increased risk for breast cancer. This work was the first to show that this protein could regulate the transcription of genes and could potentially regulate the development of Breast cancer in this fashion.[10][11][12] He also continued working on analysis of the regulation of Tec family kinases, work which he had started as a PhD student[13] and was the first to show that this family of kinases are regulated by upstream signals from Src and PI3-kinase.[14] This work had direct implications for manipulating T cell activation and thus the immune response. August joined Pennsylvania State University in 1999 as an assistant professor. There he became distinguished professor of immunology and director of Center of the Molecular Immunology and Infectious Disease. Subsequently, he moved to the Cornell University College of Veterinary Medicine, where he is a professor at the Department of Microbiology & Immunology, Howard Hughes Medical Institutes-HHMI Professor,[15] and also the vice provost for academic affairs.[16]

Honors and awards

August was awarded the Ruth Kirschstein Diversity in Science award in 2016 for his contributions to breaking down barriers for historically marginalized scientists and to the field of biochemistry and molecular biology.[17]

In 2018, August was selected to become an HHMI professor for his work with undergraduate researchers.[18] Specifically, he developed a three-stage program to support students that are transferring from community colleges. The stages include a summer research experience, faculty mentoring and peer mentoring.

References

  1. ↑ "Something about Schools". www.belizenorth.com. Archived from the original on 2001-11-20.
  2. ↑ "California State University, Los Angeles". Archived from the original on 2009-02-28. Retrieved 2008-07-29.
  3. ↑ "The Scientist". www.the-scientist.com. Archived from the original on 2007-05-04.
  4. ↑ "Cal State LA salutes its Outstanding Professors". 22 October 2013.
  5. ↑ A. August, C.J. Dao, D. Jensen, Q. Zhang, and P.Dea. "A facile catalytic deuteration of unsaturated fatty acids and phospholipids." (1993) Microchem. J. 47:224.
  6. ↑ "Avery August: Data or Data". Journal of Experimental Medicine. Retrieved 8 July 2022.
  7. ↑ Kuby Immunology, 6th Edition, TJ Kindt, BA Orborne and RA Goldsby, WH Freeman Publishers.
  8. ↑ H. Wigzell. "Immunopathogenesis of HIV infection." (1988) J Acquir Immune Defic Syndr. 1:559-65.
  9. ↑ A. August (GS). "On the molecular basis of the two signal hypothesis of T cell activation: Signaling by CD3 and CD28". Ph.D. Thesis. Cornell University.
  10. ↑ A.N.A. Monteiro, A. August, and H. Hanafusa. "Evidence for a transcriptional activation function for BRCA1 C-terminal region." (1996) Proc. Natl. Acad. Sci. 93: 13595.
  11. ↑ A.N.A. Monteiro, A. August, and H. Hanafusa. "Common BRCA1 Variants and Transcriptional Activation." (1997) Am. J. Human. Genet. 61:761.
  12. ↑ T. Ouchi, A.N.A. Monteiro, A. August, S.A. Aaronson, and H. Hanafusa. "BRCA1 regulates p53-dependent gene expression." (1998) Proc. Natl. Acad. Sci 95: 2302.
  13. ↑ A. August, S. Gibson, Y. Kawakami, T. Kawakami, G.B. Mills and B. Dupont. "CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic cell line." (1994) Proc. Natl. Acad. Sci. USA. 91:9347.
  14. ↑ A. August, A. Sadra, B. Dupont and H. Hanafusa. "Src induced activation of Inducible T cell Kinase (ITK) requires PI3 kinase activity and the Pleckstrin Homology domain of inducible T cell kinase." (1997) Proc. Natl. Acad. Sci. 94: 11227.
  15. ↑ "HHMI Professors | HHMI". www.hhmi.org. Retrieved 2022-08-07.
  16. ↑ "Avery August". 23 February 2017. Retrieved 8 July 2022.
  17. ↑ "Ruth Kirschstein Diversity in Science Award". www.asbmb.org. Retrieved 2022-05-06.
  18. ↑ "Avery August". HHMI. Retrieved 2022-05-06.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.