BRSK1

BRSK1
Identifiers
Aliases	BRSK1, hSAD1, BR serine/threonine kinase 1, SAD-B
External IDs	OMIM: 609235 MGI: 2685946 HomoloGene: 57169 GeneCards: BRSK1
EC number	2.7.11.26
Gene location (Human)
Chr.	Chromosome 19 (human)
End	55,312,562 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	4,718,996 bp
RNA expression pattern
	Top expressed in
	Brodmann area 9; ; prefrontal cortex; ; cingulate gyrus; ; ganglionic eminence; ; amygdala; ; hypothalamus; ; putamen; ; nucleus accumbens; ; caudate nucleus; ; anterior pituitary;
	Top expressed in
	superior frontal gyrus; ; prefrontal cortex; ; cerebellar cortex; ; hippocampus proper; ; cingulate gyrus; ; piriform cortex; ; primary motor cortex; ; nucleus accumbens; ; pontine nuclei; ; medial vestibular nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; metal ion binding; kinase activity; protein kinase binding; magnesium ion binding; protein serine/threonine kinase activity; ATP binding; tau-protein kinase activity; gamma-tubulin binding; tau protein binding;
Cellular component	synapse; nucleoplasm; microtubule organizing center; cytoskeleton; cell junction; cytoplasm; synaptic vesicle; centrosome; nucleus; presynaptic active zone; distal axon;
Biological process	response to ionizing radiation; neuron projection morphogenesis; intracellular signal transduction; phosphorylation; nervous system development; cell cycle; response to UV; cellular response to DNA damage stimulus; centrosome duplication; establishment of cell polarity; neurotransmitter secretion; axonogenesis; neuron differentiation; protein phosphorylation; mitotic G2 DNA damage checkpoint signaling; associative learning; regulation of neuron projection development; regulation of synaptic plasticity; regulation of axonogenesis; microtubule cytoskeleton organization involved in establishment of planar polarity; synaptic vesicle cycle; regulation of synaptic vesicle clustering;
	Sources:Amigo / QuickGO
Orthologs
	84446
	381979
	ENSG00000160469
	ENSMUSG00000035390
	Q8TDC3
	Q5RJI5
	NM_032430
	NM_001003920; NM_001168572
	NP_115806
	NP_001003920; NP_001162044
	Wikidata
View/Edit Human	View/Edit Mouse

BR serine/threonine kinase 1 is an enzyme that in humans is encoded by the BRSK1 gene.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000160469 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035390 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: BR serine/threonine kinase 1". Retrieved 2011-10-18.

External links

Human BRSK1 genome location and BRSK1 gene details page in the UCSC Genome Browser.

Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR (Feb 2004). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". The EMBO Journal. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC 381014. PMID 14976552.
Lu R, Niida H, Nakanishi M (Jul 2004). "Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function". The Journal of Biological Chemistry. 279 (30): 31164–70. doi:10.1074/jbc.M404728200. PMID 15150265.
Al-Hakim AK, Göransson O, Deak M, Toth R, Campbell DG, Morrice NA, Prescott AR, Alessi DR (Dec 2005). "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK". Journal of Cell Science. 118 (Pt 23): 5661–73. doi:10.1242/jcs.02670. PMID 16306228.
Inoue E, Mochida S, Takagi H, Higa S, Deguchi-Tawarada M, Takao-Rikitsu E, Inoue M, Yao I, Takeuchi K, Kitajima I, Setou M, Ohtsuka T, Takai Y (Apr 2006). "SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release". Neuron. 50 (2): 261–75. doi:10.1016/j.neuron.2006.03.018. PMID 16630837. S2CID 15232412.
Al-Hakim AK, Zagorska A, Chapman L, Deak M, Peggie M, Alessi DR (Apr 2008). "Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains" (PDF). The Biochemical Journal. 411 (2): 249–60. doi:10.1042/BJ20080067. PMID 18254724. S2CID 13038944.
Bright NJ, Carling D, Thornton C (May 2008). "Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation". The Journal of Biological Chemistry. 283 (22): 14946–54. doi:10.1074/jbc.M710381200. PMC 3258900. PMID 18339622.
Fogarty S, Hardie DG (Jan 2009). "C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest". The Journal of Biological Chemistry. 284 (1): 77–84. doi:10.1074/jbc.M806152200. PMC 2610510. PMID 18854318.
Stolk L, Zhai G, van Meurs JB, Verbiest MM, Visser JA, Estrada K, Rivadeneira F, Williams FM, Cherkas L, Deloukas P, Soranzo N, de Keyzer JJ, Pop VJ, Lips P, Lebrun CE, van der Schouw YT, Grobbee DE, Witteman J, Hofman A, Pols HA, Laven JS, Spector TD, Uitterlinden AG (Jun 2009). "Loci at chromosomes 13, 19 and 20 influence age at natural menopause". Nature Genetics. 41 (6): 645–7. doi:10.1038/ng.387. PMC 3000545. PMID 19448619.
He C, Kraft P, Chen C, Buring JE, Paré G, Hankinson SE, Chanock SJ, Ridker PM, Hunter DJ, Chasman DI (Jun 2009). "Genome-wide association studies identify loci associated with age at menarche and age at natural menopause". Nature Genetics. 41 (6): 724–8. doi:10.1038/ng.385. PMC 2888798. PMID 19448621.
Alvarado-Kristensson M, Rodríguez MJ, Silió V, Valpuesta JM, Carrera AC (Sep 2009). "SADB phosphorylation of gamma-tubulin regulates centrosome duplication". Nature Cell Biology. 11 (9): 1081–92. doi:10.1038/ncb1921. PMID 19648910. S2CID 41209616.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000160469 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035390 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: BR serine/threonine kinase 1". Retrieved 2011-10-18.

[1]

[2]

[3]

[4]

[5]

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

References

External links

Further reading