| BTF3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | BTF3, BETA-NAC, BTF3a, BTF3b, NACB, basic transcription factor 3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 602542 MGI: 1202875 HomoloGene: 37453 GeneCards: BTF3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Transcription factor BTF3 is a protein that in humans is encoded by the BTF3 gene.[5][6][7][8]
Function
This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes.[8]
Interactions
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000145741 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021660 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Zheng XM, Black D, Chambon P, Egly JM (May 1990). "Sequencing and expression of complementary DNA for the general transcription factor BTF3". Nature. 344 (6266): 556–9. Bibcode:1990Natur.344..556Z. doi:10.1038/344556a0. PMID 2320128. S2CID 4227320.
- ↑ Kanno M, Chalut C, Egly JM (Sep 1992). "Genomic structure of the putative BTF3 transcription factor". Gene. 117 (2): 219–28. doi:10.1016/0378-1119(92)90732-5. PMID 1386332.
- ↑ Freire MA (Apr 2005). "Translation initiation factor (iso) 4E interacts with BTF3, the beta subunit of the nascent polypeptide-associated complex". Gene. 345 (2): 271–7. doi:10.1016/j.gene.2004.11.030. PMID 15716105.
- 1 2 "Entrez Gene: BTF3 basic transcription factor 3".
- ↑ Grein S, Pyerin W (Jan 1999). "BTF3 is a potential new substrate of protein kinase CK2". Mol. Cell. Biochem. 191 (1–2): 121–8. doi:10.1023/A:1006806226764. PMID 10094400. S2CID 1057554.
External links
- Human BTF3 genome location and BTF3 gene details page in the UCSC Genome Browser.
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Transcription factor BTF3
Further reading
- Wiedmann B, Sakai H, Davis TA, Wiedmann M (1994). "A protein complex required for signal-sequence-specific sorting and translocation". Nature. 370 (6489): 434–40. Bibcode:1994Natur.370..434W. doi:10.1038/370434a0. PMID 8047162. S2CID 4353902.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Grein S, Pyerin W (1999). "BTF3 is a potential new substrate of protein kinase CK2". Mol. Cell. Biochem. 191 (1–2): 121–8. doi:10.1023/A:1006806226764. PMID 10094400. S2CID 1057554.
- Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J, Ducar M (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
- Kusumawidjaja G, Kayed H, Giese N, Bauer A, Erkan M, Giese T, Hoheise JD, Friess H, Kleeff J (2007). "Basic transcription factor 3 (BTF3) regulates transcription of tumor-associated genes in pancreatic cancer cells". Cancer Biol. Ther. 6 (3): 367–76. CiteSeerX 10.1.1.410.5257. doi:10.4161/cbt.6.3.3704. PMID 17312387. S2CID 9044882.
- Symes AJ, Eilertsen M, Millar M, Nariculam J, Freeman A, Notara M, Feneley MR, Patel HR, Patel HR, Masters JR, Ahmed A (2013). "Quantitative Analysis of BTF3, HINT1, NDRG1 and ODC1 Protein Over-Expression in Human Prostate Cancer Tissue". PLOS ONE. 8 (12): e84295. Bibcode:2013PLoSO...884295S. doi:10.1371/journal.pone.0084295. PMC 3874000. PMID 24386364.
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