Brian M. Hoffman (born August 7, 1941 in Chicago) is an American bioinorganic and physical chemist.

Career

Hoffman is a graduate of Lane Tech High School in Chicago and then studied chemistry at the University of Chicago receiving a bachelor's degree in 1962 and at Caltech with a PhD in chemistry in 1966 under the direction of Harden M. McConnell. Hoffman was briefly a postdoctoral scholar with Alexander Rich at MIT. In 1967 he started his appointment at Northwestern University, where he has remained throughout his career.

Research and recognition

Using electron-nuclear double-resonance (ENDOR) spectroscopy, Hoffman has investigated many enzyme mechanisms.[1] Subject of this work include nitric oxide synthase, cytochrome P450, nickel-iron hydrogenase, and nitrogenase.[2]

In 2012, he received the Joseph Chatt Award, in 2013 the F. A. Cotton Medal. He also received the Bruker Award[3] He is a member of the National Academy of Sciences (2006), the American Academy of Arts and Sciences (2002) and the American Association for the Advancement of Science (1983). He was a Sloan Fellow.

References

  1. ↑ Hoffman BM (2003). "ENDOR of Metalloenzymes". Accounts of Chemical Research. 36 (7): 522–529. doi:10.1021/ar0202565. PMID 12859213.
  2. ↑ Hoffman BM, Lukoyanov D, Dean DR, Seefeldt LC (2013). "Nitrogenase: A Draft Mechanism". Accounts of Chemical Research. 46 (2): 587–595. doi:10.1021/ar300267m. PMC 3578145. PMID 23289741.
  3. ↑ "ESR Spectroscopy Group".
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