Briscoe is a surname. Notable people with the surname include:
- Anne Briscoe, American biochemist
- Ben Briscoe, noted Irish politician and son of Robert Briscoe
- Brent Briscoe (1961–2017), American actor and screenwriter
- Chase Briscoe, American race car driver
- Constance Briscoe, British barrister and author
- Dezmon Briscoe, American football wide receiver
- James Briscoe (1923–2014), Football (soccer) manager
- Jay Briscoe (1984–2023), ring name of American professional wrestler Jamin "Jay" Pugh
- Jill Briscoe, international speaker, author, magazine head and wife of Stuart Briscoe
- John Briscoe, any of several people by that name
- Lennie Briscoe, a character from the Law & Order television franchise
- Lottie Briscoe, stage and silent film actress
- Mark Briscoe (born 1985), ring name of American professional wrestler Mark Pugh
- Marlin Briscoe (1945–2022), American football player
- Nicole Briscoe, American sports reporter, former Miss Illinois Teen USA
- Paul Briscoe (1930–2010), English school teacher and writer, known for spending much of his childhood in Nazi Germany
- Robert Briscoe (disambiguation), any of several people by that name
- Ryan Briscoe, Australian race car driver
- Stuart Briscoe, evangelist, pastor, author and international speaker
- Ted Briscoe, Australian rugby league footballer
- Thomas Briscoe, Welsh priest and scholar
- Tom Briscoe, English rugby league footballer
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