James Briscoe

FRS FMedSci
Alma materUniversity of Warwick (BSc)
King's College London (PhD)
AwardsEMBO Gold Medal (2008)
EMBO Member (2009)
Scientific career
FieldsDevelopmental biology[1]
InstitutionsFrancis Crick Institute
Columbia University
National Institute for Medical Research
ThesisJAKs, STATs and signal transduction in response to the interferons and interleukin-6 (1996)
Doctoral advisorIan M. Kerr
Websitebriscoelab.org/james-briscoe/

James Briscoe FRS FMedSci[2] is a senior group leader at the Francis Crick Institute in London[3][4][5][1][6] and editor-in-chief of the journal Development.[4]

Education

Briscoe was educated at the University of Warwick and King's College London where he was awarded a PhD in 1996 for research on Janus kinases (JAKS), Signal Transducers and Activators of Transcriptions (STATs) and signal transduction in response to the interferons and Interleukin-6[7] supervised by Ian M. Kerr.[2]

Research and career

Briscoe was a postdoctoral researcher at Columbia University with Thomas Jessell.[2][8] In 2000 he moved to the National Institute for Medical Research to establish his own research group and in 2001 he was elected an EMBO Young Investigator.

His research interests include the molecular and cellular mechanisms of embryonic development with a particular focus on the developing spinal cord with a particular interest in how sonic hedgehog gradients and the hedgehog signaling pathway[9] regulate the development of this tissue.[10][11][2] To address these questions, he uses a range of experimental biology and computational biology techniques with model systems that include laboratory mouse and chick embryos as well as embryonic stem cells.[2]

Awards and honours

Briscoe was awarded the EMBO Gold Medal in 2008 and elected a member of the European Molecular Biology Organization (EMBO) in 2009.[2] In 2018 he became editor-in-chief of the journal Development.[2][4] He was elected a Fellow of the Royal Society (FRS) in 2019 and is a Fellow of the Academy of Medical Sciences (FMedSci).

References

  1. 1 2 James Briscoe publications indexed by Google Scholar
  2. 1 2 3 4 5 6 7 Anon (2019). "Dr James Briscoe". royalsociety.org. London: Royal Society. Archived from the original on 2019-04-24. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)
  3. ↑ "James Briscoe: Developmental Dynamics Laboratory". crick.ac.uk. London: Francis Crick Institute.
  4. 1 2 3 Brown, Katherine (2018). "An interview with James Briscoe". Development. 145 (6): dev165274. doi:10.1242/dev.165274. ISSN 0950-1991. PMID 29588292.
  5. ↑ James Briscoe publications indexed by the Scopus bibliographic database. (subscription required)
  6. ↑ James Briscoe publications from Europe PubMed Central
  7. ↑ Briscoe, James (1996). JAKs, STATs and signal transduction in response to the interferons and interleukin-6. jisc.ac.uk (PhD thesis). King's College London (University of London). OCLC 940139742. EThOS uk.bl.ethos.336443.
  8. ↑ Briscoe, James; Arber, Silvia (2019). "Thomas M. Jessell (1951–2019)". Development. 146 (10). doi:10.1242/dev.180505. ISSN 0950-1991. PMID 31126924.
  9. ↑ Briscoe, James; Thérond, Pascal P. (2013). "The mechanisms of Hedgehog signalling and its roles in development and disease". Nature Reviews Molecular Cell Biology. 14 (7): 416–429. doi:10.1038/nrm3598. ISSN 1471-0072. PMID 23719536. S2CID 25137907.
  10. ↑ Briscoe, James; Pierani, Alessandra; Jessell, Thomas M; Ericson, Johan (2000). "A Homeodomain Protein Code Specifies Progenitor Cell Identity and Neuronal Fate in the Ventral Neural Tube". Cell. 101 (4): 435–445. doi:10.1016/S0092-8674(00)80853-3. ISSN 0092-8674. PMID 10830170.
  11. ↑ Ericson, J; Rashbass, P; Schedl, A; Brenner-Morton, S; Kawakami, A; van Heyningen, V; Jessell, T.M; Briscoe, J (1997). "Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling". Cell. 90 (1): 169–180. doi:10.1016/S0092-8674(00)80323-2. ISSN 0092-8674. PMID 9230312.
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