Preliminary round

The preliminary round first legs were played on 15–17 February, and the second legs were played on 29 February-2 March 2008.⁴

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
ASC SNIM	1–7	ES Setif	1–5	0–2
SC de Bissau	0–4	Olympique Khouribga	0–2	0–2
Invincible Eleven	w/o1	AS Kaloum Star
Renacimiento FC	2–4	Interclube	1–2	1–2
FAR Rabat	3–3 (4–5 p)	Sporting Clube da Praia	3–0	0–3
Tonnerre d'Abomey FC	0–3	Africa Sports National	0–0	0–3
APR FC	1–4	Zamalek	1–2	0–2
AS Douanes	3–2	Commune FC	0–0	3–2
Costa do Sol	2–1	AJESAIA	2–0	0–1
Royal Leopards	0–3	Dynamos	0–1	0–2
Sahel SC	2–6	Ashanti Gold SC	1–0	1–6
DC Motema Pembe	2–2 (1–4 p)	Gombe United F.C.	2–0	0–2
Vital'O FC	0–2	Coton Sport FC	0–1	0–1
FC 105 Libreville	4–3	Hearts of Oak SC	3–0	1–3
Renaissance FC	0-3	TP Mazembe	0-32	n/p
Stade Malien	1–2	Primeiro de Agosto	1–2	0–0
ASC Saloum	1–3	Club Africain	1–2	0–1
ASKO Kara	4-1	US Douala	3–1	1–0
Simba SC	4–1	Awassa City FC	3–0	1–1
Enyimba FC	7–3	CSMD Diables Noirs	4–1	3–2
Tusker FC	w/o	Al Tahrir	3
US Stade Tamponnaise	4–1	St Michel United	3–1	1–0
Platinum Stars	4–1	Lesotho Correctional Services	4–0	0–1
Curepipe Starlight SC	2–1	Coin Nord	2–0	0–1
Miembeni SC	0–5	Mamelodi Sundowns	0–1	0–4
Uganda Revenue Authority SC	0–2	ZESCO United Football Club	0–2	0–0

Byes: ASEC Mimosas, Etoile du Sahel, JS Kabylie, Al Ittihad, Al Ahly, and Al Hilal.

¹ Invincible Eleven withdrew.
² CAF ordered that the tie was to be played over one leg in Kinshasa due to the civil war in Chad, but Renaissance FC objected to the ruling and refused to travel; they were ejected from the competition, fined $4000 and banned from CAF competitions for three years.
³ Tusker FC were ejected from the competition and fined $5000 after Kenyan immigration officials refused the appointed match officials for the first leg entry into the country.
⁴ Wallidan FC and FC Civics withdrew before the draw.

Note: Clubs from the Central African Republic, Djibouti, Kenya, Liberia, Malawi, São Tomé and Príncipe, Sierra Leone and Somalia all had their entries rejected for failure to fulfil their financial obligations.^[1]

First round

The 1/16 Finals first leg matches were played on 21–23 March and the second legs were played on 4–6 April 2008.

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
Olympique Khouribga	2–2 (3–0 p)	ES Setif	2–0	0–2
ASEC Mimosas	2–1	AS Kaloum Star	1–1	1–0
Sporting Clube da Praia	2–2 (a)	Interclube	2–1	0–1
Zamalek	2–2 (5–4p)	Africa Sports National	2–0	0–2
Etoile du Sahel	5–3	AS Douanes	5–0	0–3
Dynamos	4–2	Costa do Sol	3–0	1–2
JS Kabylie	3–0	Ashanti Gold SC	3–0	0–0
Coton Sport FC	6–2	Gombe United F.C.	5–0	1–2
TP Mazembe	2–1	FC 105 Libreville	1–1	1–0
Al Ittihad Tripoli	2–2 (a)	1º de Agosto	1–0	1–2
ASKO Kara	2–4	Club Africain	2–0	0–4
Enyimba FC	7–1	Simba SC	4–0	3–1
Al Ahly	6–01	Al Tahrir	3–0	3–0
Platinum Stars	3–1	US Stade Tamponnaise	2–0	1–1
Mamelodi Sundowns	4–0	Curepipe Starlight SC	3–0	1–0
Al Hilal	3–1	ZESCO United Football Club	2–0	1–1

¹Al Tahrir withdrew due to internal dissent.^[2]

Second round

The 1/8 Finals first legs were played on 25–27 April and the second legs were played on 9–11 May 2008.

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
ASEC Mimosas	(a) 1–1	Olympique Khouribga	0–0	1–1
Zamalek	4–2	Interclube	3–0	1–2
Dynamos	2–0	Etoile du Sahel	1–0	1–0
Coton Sport FC	4–2	JS Kabylie	3–0	1–2
Al Ittihad Tripoli	2–3	TP Mazembe	2–1	0–2
Enyimba FC	6–3	Club Africain	5–1	1–2
Platinum Stars	2–3	Al Ahly	2–1	0–2
Al Hilal	4–3	Mamelodi Sundowns	4–2	0–1

Group A

Pos	Team	Pld	W	D	L	GF	GA	GD	Pts	Qualification		AHL	DYN	ASEC	ZAM
1	Al Ahly	6	3	3	0	9	6	+3	12	Advance to knockout stage		—
2	Dynamos	6	3	0	3	6	6	0	9				—
3	ASEC Mimosas	6	1	3	2	7	6	+1	6					—
4	Zamalek	6	1	2	3	4	8	−4	5						—

Group B

Pos	Team	Pld	W	D	L	GF	GA	GD	Pts	Qualification		COT	ENY	TPM	HIL
1	Coton Sport FC	6	3	1	2	6	5	+1	10	Advance to knockout stage		—
2	Enyimba	6	3	0	3	10	10	0	9				—
3	TP Mazembe	6	2	2	2	7	5	+2	8					—
4	Al Hilal	6	1	3	2	7	10	−3	6						—

Bracket

	Semi-finals							Final
	1	Enyimba	0	0	0
	4	Al Ahly	0	1	1
								Al Ahly		2	2	4
								Coton Sport		0	2	2
	3	Dynamos	0	0	0
	2	Coton Sport	1	4	5

Semifinals

The first legs were played on 5 October and the second legs on 17–19 October.

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
Enyimba	0–1	Al Ahly	0–0	0–1
Dynamos	0–5	Coton Sport	0–1	0–4

Final

2 November 2008

18:00 GMT

Al Ahly	2–0	Coton Sport
Gomaa 4' Flávio 15'	Report

Cairo International Stadium, Cairo

Referee: Jerome Damon (South Africa)

16 November 2008

14:00 GMT

Coton Sport	2–2	Al Ahly
Lassina Abdoul Karim 45' Ousmaïla Baba 63'	Report	Ahmed Hassan 38' Shady 89'

Stade Omnisport de Garoua, Garoua

Referee: Djamel Haimoudi (Algeria)